Recurrence of Cardiac Sarcoidosis in a Heart Transplant Recipient

Yager, Jonathan E.E.; Hernandez, Adrian F.; Steenbergen, Charles; Persing, Bradley F.; Russell, Stuart D.; Milano, Carmelo A.; Felker, G. Michael

doi:10.1016/j.healun.2005.02.016

Cited by 88 publications

(27 citation statements)

References 4 publications

(4 reference statements)

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“…Heart transplantation is not universally considered for patients with CS who experience end-stage heart failure because of the potential for sarcoid recurrence in the cardiac allograft and/or progression of extracardiac disease (36,37). However, a few case series have reported either no significant difference or improvement in survival among patients with CS who undergo heart transplantation, compared with patients who undergo heart transplantation for other conditions (38)(39)(40).…”

Section: Therapymentioning

confidence: 99%

Cardiac Sarcoidosis: The Challenge of Radiologic-Pathologic Correlation:From the Radiologic Pathology Archives

Jeudy¹,

Burke²,

White³

et al. 2015

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Cardiac sarcoidosis is a rare but potentially fatal disorder with a nonspecific spectrum of clinical manifestations, including conduction disorders, congestive heart failure, ventricular arrhythmias, and sudden cardiac death. Although early treatment to improve morbidity and mortality is desirable, sensitive and accurate detection of cardiac sarcoidosis remains a challenge. Except for the histopathologic finding of noncaseating granulomas in an endomyocardial biopsy specimen, most diagnostic tests are limited and nonspecific at best. Therefore, the decision to initiate treatment is based largely on the patient's clinical symptoms and the course of the disease, rather than histologic confirmation. Successful recognition of cardiac sarcoidosis ultimately requires rigorous collaboration among a clinician, radiologist, and pathologist. Advanced imaging modalities, such as cardiac magnetic resonance imaging and positron emission tomography with fluorodeoxyglucose, have become increasingly useful in facilitating diagnosis and therapeutic monitoring, although limited prospective studies exist. This article describes the clinical parameters and pathologic findings of cardiac sarcoidosis and the advanced imaging features and differential diagnostic challenges that must be considered for a successful diagnostic approach. In addition, to improve the understanding of abnormalities detected with different imaging modalities, we suggest a unified terminology in describing radiologic findings related to cardiac sarcoidosis.

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Section: Therapymentioning

confidence: 99%

Cardiac Sarcoidosis: The Challenge of Radiologic-Pathologic Correlation:From the Radiologic Pathology Archives

Jeudy¹,

Burke²,

White³

et al. 2015

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“…A more recent study of 19 patients with cardiac sarcoidosis indicated 5-year survival rates similar to the general cardiac transplant population at 79% and 83%, respectively 131. A major consideration is recurrence of sarcoidosis in the transplanted heart,11 130 132 133 although patients maintained on low-dose steroids can remain free of disease recurrence 134. Sarcoidosis may also occur in recipients of allografts from donors who had unsuspected (occult) sarcoidosis 135.…”

Section: Managementmentioning

confidence: 99%

Cardiac sarcoidosis: diagnosis and management

Dubrey

Sharma

Underwood

et al. 2015

Postgraduate Medical Journal

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Cardiac sarcoidosis is one of the most serious and unpredictable aspects of this disease state. Heart involvement frequently presents with arrhythmias or conduction disease, although myocardial infiltration resulting in congestive heart failure may also occur. The prognosis in cardiac sarcoidosis is highly variable, which relates to the heterogeneous nature of heart involvement and marked differences between racial groups. Electrocardiography and echocardiography often provide the first clue to the diagnosis, but advanced imaging studies using positron emission tomography and MRI, in combination with nuclear isotope perfusion scanning are now essential to the diagnosis and management of this condition. The identification of clinically occult cardiac sarcoidosis and the management of isolated and/or asymptomatic heart involvement remain both challenging and contentious. Corticosteroids remain the first treatment choice with the later substitution of immunosuppressive and steroid-sparing therapies. Heart transplantation is an unusual outcome, but when performed, the results are comparable or better than heart transplantation for other disease states. We review the epidemiology, developments in diagnostic techniques and the management of cardiac sarcoidosis.

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“…En el seguimiento en una clínica de falla cardíaca se puede plantear el trasplante, dependiendo de lo avanzado del compromiso de otros órganos (42,43); en algunos casos el diagnóstico de la enfermedad se hace postrasplante, en el análisis histopatológico del corazón explantado (44). Puede ocurrir recurrencia de la sarcoidosis cardíaca, pero se desconoce su incidencia (45,46).…”

Section: Cirugía Y Trasplanteunclassified

Sarcoidosis cardíaca. Estado del arte

Muñoz-Ortiz

Arévalo-Guerrero

Abad³

et al. 2016

iatreia

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RESUMENLa sarcoidosis es una enfermedad infrecuente de etiología desconocida, descrita hace más de 80 años, y caracterizada por un trastorno multisistémico con presencia de lesiones granulomatosas no caseificantes. El compromiso cardíaco es variable según la región estudiada, pero en general se acepta que 5 % de los pacientes con sarcoidosis sistémica tienen infiltración cardíaca con evidencia clínica; sin embargo, estudios de autopsia indican que hasta 20 % a 30 % de los pacientes con sarcoidosis tienen afectación miocárdica.Se han propuesto factores ambientales, ocupacionales e infecciosos como los disparadores del proceso en individuos con predisposición genética. La sarcoidosis cardíaca puede tener un amplio espectro de presentaciones e incluso puede ser asintomática; las manifestaciones más frecuentes son por falla cardíaca, alteraciones del ritmo cardíaco y arritmias ventriculares letales. El tratamiento incluye medicamentos para la falla cardíaca, esteroides e inmunosupresores, tratamiento de las arritmias letales con ablación y/o cardiodesfibrilador implantable y, en casos avanzados, el trasplante cardíaco. PALABRAS CLAVEArritmias; Insuficiencia cardíaca; Sarcoidosis SUMMARYCardiac sarcoidosis. State of the art Sarcoidosis is a rare disease of unknown etiology, described over 80 years ago. It is a multisystemic disorder characterized by the presence of granulomatous lesions without caseation.

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Recurrence of Cardiac Sarcoidosis in a Heart Transplant Recipient

Cited by 88 publications

References 4 publications

Cardiac Sarcoidosis: The Challenge of Radiologic-Pathologic Correlation:From the Radiologic Pathology Archives

Cardiac Sarcoidosis: The Challenge of Radiologic-Pathologic Correlation:From the Radiologic Pathology Archives

Cardiac sarcoidosis: diagnosis and management

Sarcoidosis cardíaca. Estado del arte

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