Recurrence of hepatocellular carcinoma after liver transplant: Patterns and prognosis

Roayaie, Sasan; Schwartz, Jonathan D.; Sung, Max W.; Emre, Sükrü; Miller, Charles M.; Gondolesi, Gabriel; Krieger, Nancy; Schwartz, Myron

doi:10.1002/lt.20128

Cited by 421 publications

(421 citation statements)

References 12 publications

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“…Several transplant groups have demonstrated that, apart from number and size of tumor nodules, parameters of tumor biology, such as differentiation and microvascular tumor invasion (MVI) play an important role for predicting patient prognosis, and should be, therefore, incorporated in the pretransplant selection process (4,8,9,10,11). However, since expanding the selection criteria may increase the risk of tumor relapse, its justification will very much depend on outcome of posttransplant HCC recurrence (13)(14)(15)(16)(17)(18)(19) …”

Section: Introductionmentioning

confidence: 99%

Long-term survival after recurrent hepatocellular carcinoma in liver transplant patients: Clinical patterns and outcome variables

Kornberg

Küpper

Tannapfel

et al. 2010

European Journal of Surgical Oncology (EJSO)

121

122

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Section: Introductionmentioning

confidence: 99%

Long-term survival after recurrent hepatocellular carcinoma in liver transplant patients: Clinical patterns and outcome variables

Kornberg

Küpper

Tannapfel

et al. 2010

European Journal of Surgical Oncology (EJSO)

121

122

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“…ROAYAIE et al (19) ao analisarem 311 pacientes com HCC submetidos a transplante, encontraram taxa de recurrência de 18%. A mediana da época em que foi diagnosticada a recurrência foi 12 meses pós-TH, variando de 1,5 a 60 meses.…”

Section: Discussionunclassified

Resultados do transplante hepático em pacientes com diagnóstico pré-operatório de hepatocarcinoma

Parolin

Coelho

Matias

et al. 2006

Arq. Gastroenterol.

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“…[45][46][47][48] If explant pathology is within the currently accepted criteria for transplantation then rate of recurrence is low (8%) but on the other hand If pathology is outside of the criteria then chance of recurrence is as high as 50%. 45 In two of above mentioned studies majority of patients had recurrence within 12 and 18 months respectively.…”

Section: Surveillance Strategy Post Successful Treatment For Hepatocementioning

confidence: 99%

Role of Surveillance in Prevention of Hepatocellular Carcinoma

Panda

2014

Journal of Clinical and Experimental Hepatology

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Hepatocellular carcinoma is a common malignancy and one of the important public health problems in India. The surveillance of hepatocellular carcinoma (HCC) is an established approach to detect early cancers in patients with defined risks. However, there are still controversies and issues to be addressed regarding the optimal surveillance methods and interval. The current level of awareness among physicians in India about surveillance is low and the need and most cost effective surveillance strategy in developing country like ours is unclear. This article has tried to discuss these issues in their appropriate perspective. To address this complicated issue, a multicenter randomized prospective study however may be required. ( J CLIN EXP HEPATOL 2014;4:S43-S49) H epatocellular carcinoma (HCC) is the fifth commonest cancer worldwide and third commonest cause of cancer related mortality. 1 In India, the mean incidence of HCC as per four population-based registries was 2.77% for males and 1.38% for females. The prevalence of HCC in India varies from 0.2% to 1.6%. 2,3 It is interesting to note that the consolidated data from cancer registries of India do not reflect HCC as an important malignancy. 4 Risk of HCC development is high in patients with liver cirrhosis of any etiology, particularly with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection. 5 Since India has a high prevalence of HBV infection (4% of population, i.e about 40 million Indians) 6 as well as HCV infection (0.3-1.5%) it could contribute to the high incidence of HCC. 7 Other risk factors for HCC like high prevalence of Nonalcoholic Fatty Liver Disease (NAFLD) obesity, diabetes, alcohol consumption among males are also present in India.Nonalcoholic Fatty Liver Disease (NAFLD) particularly its more aggressive form, nonalcoholic steatohepatitis (NASH) is an important factor which can lead to cirrhosis and HCC. It is estimated that nearly two-thirds of obese people have some form of fatty liver, ranging from steatosis to NASH. NASH can progress to liver cirrhosis in 3%-15% and subsequently to liver cancer. 8 A study by Prasad et al showed that age-standardized prevalence rates of metabolic syndrome were 33.5% overall, 24.9% in males and 42.3% in females in India. Authors concluded that metabolic syndrome is a significant public health problem even in one of the poorest states of India. 9 Hence NASH is particularly important in countries like India where metabolic syndrome is on the rise.It is important to note that in the absence of an effective screening program and only 7% of population being covered by cancer registries, under reporting cannot be ruled out. 10 A recent study in which 130 trained physicians independently assigned causes to 122429 deaths, which occurred in 1$1 million homes in 6671 small areas that were randomly selected to be representative of all of India, based on a structured nonmedical surveyor's field report has put the liver cancer as the 4th commonest cause of death in male and 8th commonest cause of death i...

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Recurrence of hepatocellular carcinoma after liver transplant: Patterns and prognosis

Cited by 421 publications

References 12 publications

Long-term survival after recurrent hepatocellular carcinoma in liver transplant patients: Clinical patterns and outcome variables

Long-term survival after recurrent hepatocellular carcinoma in liver transplant patients: Clinical patterns and outcome variables

Resultados do transplante hepático em pacientes com diagnóstico pré-operatório de hepatocarcinoma

Role of Surveillance in Prevention of Hepatocellular Carcinoma

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