Recurrence of Ocular Toxoplasmosis after Vitrectomy: Case Report and Review

Souza, Guilherme Macedo; Souza, Carlos Eduardo de; Passos, Renato Magalhães; Nascimento, Heloisa; Belfort, Rubens

doi:10.1080/09273948.2022.2026408

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…In most cases with ocular Toxoplasmosis , a classic fundus examination showed a chorioretinitis, characterized by being an atypical inflammatory yellow-white, round, single lesion of approximately an optic disc in diameter. [ 6 , 7 ] The serology test detected anti- T gondii IgG positive. Since the serum antibody level of patients with T gondii retinochoroiditis is generally low, and the level of antibody has no significant correlation with the severity of fundus lesions, [ 8 ] therefore, any serum anti-toxoplasma antibody positive regardless of the titer, as long as it is combined with typical fundus lesions diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Antibodies against Toxoplasma gondii positive in serum and aqueous humor to diagnose clinically suspected ocular toxoplasmosis: A case report

Niu

Wang

et al. 2022

Medicine

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Introduction: Previously, diagnosis of ocular toxoplasmosis is based on clinical symptoms and Toxoplasma serology. Checking serological indicators often cannot reflect the real intraocular situation, and may even mislead clinicians to make wrong judgments.Patient concerns: A 38-year-old male patient visited our ophthalmology clinic with a chief complaint of decreased vision for about 5 days in his right eye.Diagnosis: Aqueous humor sample analysis found Toxoplasma DNA detectable, and Toxoplasma immunoglobulin G (IgG) and immunoglobulin M (IgM) to be positive. His serum Toxoplasma IgG was also positive (10.04 IU/mL; reference range: 0 to 7.2 IU/ mL). Therefore, the final diagnose was ocular toxoplasmosis involving his right eye.Interventions: Oral prednisone 60 mg/day and azithromycin 0.25 g/day were started. Oral antibiotic treatment for toxoplasma was continued for 4 weeks, and prednisone followed by weekly stepwise tapering in steps of 10 mg/day.Outcomes: The BCVA and fundus of right eye remained stable after treatment at follow-up.Conclusions: This article reported a case of ocular Toxoplasma gondii infection diagnosis by serum and aqueous humor antibody tests. We provide some additional information on the T gondii infection diagnosis.

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Section: Discussionmentioning

confidence: 99%

Antibodies against Toxoplasma gondii positive in serum and aqueous humor to diagnose clinically suspected ocular toxoplasmosis: A case report

Niu

Wang

et al. 2022

Medicine

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Not Always Toxoplasmosis: Active Retinochoroiditis Presumably Secondary to Herpes in Eyes with Hyperpigmented Retinochoroidal Previous Scars

Souza,

de Souza,

Finamor

et al. 2024

Ocular Immunology and Inflammation

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Atypical pattern of ocular toxoplasmosis: recurrent inner foveal toxoplasmic retinitis (rifter)

Souza,

Biccas,

Maia

et al. 2023

Int J Retin Vitr

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Failure to recognize the different possible clinical presentations of ocular toxoplasmosis may delay diagnosis and treatment, compromising visual prognosis. The aim of this paper is to describe an atypical pattern of ocular toxoplasmosis, not yet described. Five Brazilian patients, from 4 different referral centers, presented similar atypical pattern of ocular toxoplasmosis characterized by mild vitritis, foveal cavitation involving predominantly all retinal layers associated with adjacent inner retinal necrosis (a necrotizing retinitis with a persisting inner retinal tissue bridge and loss of subjacent retinal layers). The appearance of the OCT image resembling a “rift”, led the authors to define this pattern as a Recurrent Inner Foveal Toxoplasmic Retinitis (RIFTER), which can be considered as a new description of an atypical pattern of toxoplasma retinochoroiditis, and clinicians should be aware of it and consider testing for toxoplasmosis in patients with similar findings.

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Recurrence of Ocular Toxoplasmosis after Vitrectomy: Case Report and Review

Cited by 3 publications

References 35 publications

Antibodies against Toxoplasma gondii positive in serum and aqueous humor to diagnose clinically suspected ocular toxoplasmosis: A case report

Antibodies against Toxoplasma gondii positive in serum and aqueous humor to diagnose clinically suspected ocular toxoplasmosis: A case report

Not Always Toxoplasmosis: Active Retinochoroiditis Presumably Secondary to Herpes in Eyes with Hyperpigmented Retinochoroidal Previous Scars

Atypical pattern of ocular toxoplasmosis: recurrent inner foveal toxoplasmic retinitis (rifter)

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