Recurrence of Subacute Thyroiditis Over 10 Years after the First Attack in Three Cases.

Yamamoto, Makiko; Saito, Shintaro; Sato, Toshiro; Tamura, Makoto; Kudo, Yoshinori; Yoshida, Katsumi; Kaise, Kazuro; Kaise, Nobuko; Fukazawa, Hiroshi; Itagaki, Yoichi; Yoshinaga, Kaoru

doi:10.1507/endocrj1954.35.833

Cited by 25 publications

(22 citation statements)

References 9 publications

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“…rence of SAT with HLA B35 has also been reported (13)(14)(15) (4,16,17). Another report (17) and our data suggested that the presence of antithyroid autoantibodies was not correlated with the recurrent…”

Section: F I G U R E 1 ( A) Ag E D I S T R I B U T I O N O F P a T supporting

confidence: 73%

Clinical Characteristics of 852 Patients with Subacute Thyroiditis before Treatment

et al. 2008

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Section: F I G U R E 1 ( A) Ag E D I S T R I B U T I O N O F P a T supporting

confidence: 73%

Clinical Characteristics of 852 Patients with Subacute Thyroiditis before Treatment

et al. 2008

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“…The recurrent episodes were similar to the first episodes of SAT. The titers of various viral antibodies were not increased during the clinical course of recurrence (39). In a larger study that evaluated data for 3,344 patients with SAT between 1970 and 1993, SAT recurred in 48 of 3,344 patients (1.4%) (mean, 14.5 Ϯ 4.5 yr after the first episode).…”

Section: Discussionmentioning

confidence: 92%

Clinical Features and Outcome of Subacute Thyroiditis in an Incidence Cohort: Olmsted County, Minnesota, Study

Fatourechi¹,

Aniszewski²,

Fatourechi³

et al. 2003

The Journal of Clinical Endocrinology &Amp; Metabolism

356

307

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Subacute thyroiditis (SAT), or granulomatous thyroiditis, is an inflammatory thyroid condition associated with pain and systemic symptoms. Few community studies are available. We studied the 160 patients with SAT in Olmsted County, Minnesota, seen between January 1, 1960, and December 30, 1997. Subjects were identified through the medical diagnostic index of the Rochester Epidemiology Project. The overall age- and sex-adjusted incidence from 1960 through 1997 was 4.9 cases per 100,000/yr. In the most recent 28-yr period (1970-1997), 94 patients were identified. In this group, pain was the presenting symptom in 96%. SAT recurred in 4% of the patients 6-21 yr after the initial episode. Corticosteroid therapy was given to 36%. Early-onset hypothyroidism occurred both in patients receiving corticosteroid therapy (29%) and in those not receiving corticosteroid therapy (37%). At latest follow-up, significantly more patients who had received corticosteroid therapy had a diagnosis of hypothyroidism than the group without corticosteroid therapy (25% vs. 10%, P < 0.05; overall rate of hypothyroidism, 15%). Early transient hypothyroidism is common in SAT. Permanent hypothyroidism is less common, and only 15% of the patients are receiving T(4) therapy after 28 yr of follow-up. Symptomatic relief is achieved with corticosteroid therapy, but such therapy does not prevent early- and late-onset thyroid dysfunction.

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“…Previous studies used blood Tg concentrations as a marker of the early phase of SAT [13][14][15]. Another study identified high blood concentrations of interleukin-6 in thyrotoxic patients, but the levels returned to within the normal range after remission [16].…”

Section: Discussionmentioning

confidence: 99%

Prednisolone Dosing Regimen for Treatment of Subacute Thyroiditis

Arao

Okada

Torimoto

et al. 2015

J UOEH

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: The rate of recurrence of subacute thyroiditis (SAT) during prednisolone (PSL) therapy is approximately 10 to 20%. However, there is little or no information on the time period to relapse following administration of a tapered dose of PSL and the factors associated with such relapse. The aim of this study was to determine the correlation between SAT recurrence and PSL tapering regimen used in the treatment of SAT. This study was a medical record-based retrospective study and involved 26 patients (3 men, 23 women) who received PSL therapy for SAT. The primary endpoint was the association between recurrence and number of days required to taper daily PSL dose to 5 mg. The secondary endpoint was the relationship between recurrence and several variables including age, clinical score, free thyroxine, inf lammatory reaction, thyroglobulin, total treatment time, total dose of PSL and presence or absence of creeping thyroiditis. The SAT recurrence rate was 15.3%. There was no significant difference in the initial PSL dose between the non-recurrence and recurrence groups (27.5 mg vs 24.5 mg, P = 0.302). However, for the primary endpoint, significant differences were found between the two groups in time required for tapering PSL to 5 mg/day (non-recurrence: 44.3 ± 15.3 days, recurrence: 19.0 ± 11.9 days, P = 0.012). None of the clinical variables evaluated correlated significantly with SAT relapse. In conclusion, to prevent recurrence of SAT, consideration should be given to the period required for PSL tapering to 5 mg/day.

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Recurrence of Subacute Thyroiditis Over 10 Years after the First Attack in Three Cases.

Abstract: We saw a total

Cited by 25 publications

References 9 publications

Clinical Characteristics of 852 Patients with Subacute Thyroiditis before Treatment

Clinical Characteristics of 852 Patients with Subacute Thyroiditis before Treatment

Clinical Features and Outcome of Subacute Thyroiditis in an Incidence Cohort: Olmsted County, Minnesota, Study

Prednisolone Dosing Regimen for Treatment of Subacute Thyroiditis

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