Recurrence rates in patients with HER2+ breast cancer who achieved a pathological complete response after neoadjuvant pertuzumab plus trastuzumab followed by adjuvant trastuzumab: a real-world evidence study

O’Shaughnessy, Joyce; Robert, Nicholas J.; Annavarapu, Srinivas; Zhou, Jie; Sussell, Jesse; Cheng, Anna; Fung, Alan S.

doi:10.1007/s10549-021-06137-3

Cited by 18 publications

(15 citation statements)

References 18 publications

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“…This may be due to the large number of Her-2 negative patients who might have suffered recurrence due to other factors such as expression of other oncogenic proteins, continued use of risk factors, not receiving, or completing radiotherapy etc. Usually, the effect of Her-2 on recurrence has been observed solely on Her-2 positive cohorts to provide a better understanding [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Hormone receptors AR, ER, PR and growth factor receptor Her-2 expression in oral squamous cell carcinoma: Correlation with overall survival, disease-free survival and 10-year survival in a high-risk population

et al. 2022

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Oral squamous cell carcinoma (OSCC) comprises most of head and neck neoplasms and is one of the highest-ranking and lethal cancers in Pakistan due to prevailing mouth habits. Several types of receptors act as prognostic markers and targets for therapy in some cancers, but their application in OSCC is largely unexplored. This study aimed to evaluate the expression of hormonal receptors and Her-2 in OSCC patients and correlate it with 10-year, overall and disease-free survival. To achieve this objective, immunohistochemistry for Her-2, AR, ER and PR was performed on 100 formalin-fixed paraffin-embedded primary OSCC specimens. Receptor expression was correlated with mouth habits and clinicopathological features and patient survival was analyzed using Kaplan-Meier method and Cox regression univariate analysis. We observed that in 100 patients, there were 57 males and 43 females. Immunopositive Her-2 expression was observed in 21% of patients, AR in 13%, ER in 3% and 0% for PR. Patients with betel quid/areca nut mouth habits had significantly absent Her-2 expression (P = 0.035). Also, Her-2 negative patients were also negative for AR expression (P = 0.002). Her-2 positive patients had poor 10-year survival (P = 0.041). A trend of low survival and high recurrence rate was observed in AR positive patients, but this was not significant (P = 0.072). No statistically relevant correlations were seen in the case of ER and PR. In conclusion, Her-2 may be a valuable marker for predicting long-term prognosis of OSCC patients.

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Section: Discussionmentioning

confidence: 99%

Hormone receptors AR, ER, PR and growth factor receptor Her-2 expression in oral squamous cell carcinoma: Correlation with overall survival, disease-free survival and 10-year survival in a high-risk population

et al. 2022

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“…While current treatment guidelines advocate continued HER2-targeted therapy in the adjuvant setting in patients with a pCR [ 8 , 10 ], they generally do not distinguish between single or dual HER2 blockade, likely because these regimens have not been directly compared in this setting in a prospective clinical trial. A recent real-world study of patients with HER2-positive EBC who attained a pCR after treatment with chemotherapy in combination with pertuzumab and trastuzumab in the neoadjuvant setting and who were treated with trastuzumab in the adjuvant setting demonstrated a 90% 4-year EFS rate [ 26 ]. These real-world data are consistent with our pooled analysis from randomized clinical trial data highlighting the risk of recurrence in patients who had attained a pCR and who were subsequently treated with trastuzumab alone in the adjuvant setting.…”

Section: Discussionmentioning

confidence: 99%

Event-Free Survival in Patients with Early HER2-Positive Breast Cancer with a Pathological Complete Response after HER2-Targeted Therapy: A Pooled Analysis

Swain

Macharia

Cortés

et al. 2022

Cancers

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The standard-of-care for patients with pathological complete response (pCR) after neoadjuvant human epidermal growth factor receptor 2 (HER2)-targeted therapy plus chemotherapy is continuation of HER2-targeted therapy in the adjuvant setting. Our objective was to evaluate risk of recurrence or death in these patients and determine if outcomes differed by the HER2-targeted regimen received in each setting. We analyzed patient-level data from five randomized trials evaluating trastuzumab, pertuzumab, or both as part of systemic neoadjuvant and adjuvant therapy for HER2-positive early breast cancer, and assessed event-free survival (EFS) in 1763 patients. Patients with pCR had decreased risk of an EFS event versus those with residual disease (unadjusted hazard ratio [HR] = 0.35; 95% confidence interval [CI]: 0.27–0.46). Regardless of pCR status, after adjusting for baseline factors, reduction in EFS event risk was greater in patients administered pertuzumab/trastuzumab in both settings versus those administered only trastuzumab in both settings (HR = 0.36; 95% CI: 0.26–0.49), or pertuzumab/trastuzumab in the neoadjuvant setting and only trastuzumab in the adjuvant setting (HR = 0.67; 95% CI: 0.47–0.96). Patients with pCR had longer EFS than those with residual disease. Patients treated with pertuzumab/trastuzumab in both the neoadjuvant and adjuvant settings had the lowest risk of breast cancer recurrence.

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“…Other clinical trials in which pertuzumab was added to various chemotherapy backbones had 3-year event free-survival (EFS)-rates ranging from 92 to 94% and 5-year EFS ranging from 82% to 94% [ [12] , [13] , [14] , [15] ]. Previously published comparative real world studies only evaluated pCR or only assessed recurrence-rates in patients achieving a pCR [ [16] , [17] , [18] , [19] ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of neoadjuvant treatment with or without pertuzumab in patients with stage II and III HER2-positive breast cancer: a nationwide cohort analysis of pathologic response and 5-year survival

et al. 2022

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Recurrence rates in patients with HER2+ breast cancer who achieved a pathological complete response after neoadjuvant pertuzumab plus trastuzumab followed by adjuvant trastuzumab: a real-world evidence study

Cited by 18 publications

References 18 publications

Hormone receptors AR, ER, PR and growth factor receptor Her-2 expression in oral squamous cell carcinoma: Correlation with overall survival, disease-free survival and 10-year survival in a high-risk population

Hormone receptors AR, ER, PR and growth factor receptor Her-2 expression in oral squamous cell carcinoma: Correlation with overall survival, disease-free survival and 10-year survival in a high-risk population

Event-Free Survival in Patients with Early HER2-Positive Breast Cancer with a Pathological Complete Response after HER2-Targeted Therapy: A Pooled Analysis

Efficacy of neoadjuvant treatment with or without pertuzumab in patients with stage II and III HER2-positive breast cancer: a nationwide cohort analysis of pathologic response and 5-year survival

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