Recurrent Airway Obstruction and Inflammatory Airway Disease

Determination of irritant threshold concentrations of multiple tree, grass, weed and mould allergens for intradermal testing of horses residing in the southern USA

“…These horses have respiratory disease characterized by bronchospasm, excessive airway mucus production, coughing, exercise intolerance and dyspnoea . Previous work has demonstrated a seasonal exacerbation of these clinical signs in affected horses, which has been associated with increased environmental levels of fungal spores and grass pollen . These findings suggest a possible role for environmental allergens in the pathogenesis of this condition, although there is conflicting evidence regarding the exact immunological mechanism involved in the mediation of these responses .…”

“…In addition to dermatological signs, horses can also develop respiratory issues that may be associated with environmental exposure to certain airborne allergens . In the southeastern United States, summer pasture‐associated obstructive pulmonary disease (SPAOPD) is a condition seen in horses kept outdoors .…”

“…These findings suggest a possible role for environmental allergens in the pathogenesis of this condition, although there is conflicting evidence regarding the exact immunological mechanism involved in the mediation of these responses . Nonetheless, it is hoped that ASIT may eventually prove to be an effective method for the treatment of these disorders …”