Recurrent aphthous stomatitis in Behçet's disease: clinical featueres and correlation with systemic disease expression and severity

Abstract

A: Recurrent aphthous stomatitis in Behçet's disease: clinical features and correlation with systemic disease expression and severity. J Oral Pathol Med 1999; 28: 193-6. C Munksgaard, 1999. Behçet's disease (BD) is a multisystem disease, in which recurrent aphthous stomatitis (RAS) is a universal finding. We studied the expression of RAS in patients with BD, and the correlation between major or minor RAS and systemic expression and severity of the disease. Thirty-five patients with BD were studied, of whom 13 (37%) had major, 21 (60%) had minor and one (3%) had herpetiform RAS. The frequency of major RAS was significantly higher compared with a control group of patients with idiopathic RAS (37% vs 9%, P∞0.05). The BD patients with major RAS had significantly more relapses of oral ulceration in a year, higher numbers of oral ulcers per relapse, and longer duration of aphthous epi-Key words: Behçet's disease; disease sodes, compared with patients with minor RAS. Oral ulcers also appeared at a spectrum; recurrent aphthous stomatitis; significantly younger age in patients with major than with minor RAS. However, severity the systemic expression of the disease, as well as the disease severity score, were Ilan Krause, Department of Medicine ''B'' similar in patients with major and minor RAS. The results of this study indicate Rabin Medical Center, Beilinson Campus, that major RAS is common in patients with BD, and is associated with a more Petah-Tiqva, 49100, Israel severe, repeated and prolonged oral disease. Nevertheless, the presence of major RAS in BD does not predict a more severe systemic illness.

Outcome Measures Used in Clinical Trials for Behçet Syndrome: A Systematic Review

“…This was used in 15/248 (6.0%) of published studies 38,46,51,57,104-114 . Several researchers used their own definition of disease severity 12,32,60,65,82,115,116,117 .…”

Behçet’s syndrome: Facts and controversies

“…For recurrent aphthous stomatitis, there was no relation between gender and types of aphthae. [13][14][15] According to the International Study Group (ISG) for Behçet's Syndrome diagnostic criteria, aphthae must recur more than three times a year for diagnosis of Behçet's syndrome. 16 Recurrent aphthous stomatitis also is seen in association with other conditions such as inflammatory bowel disease (IBD), celiac disease, hematinic deficiencies, systemic lupus erythematosus, reactive arthritis, formerly called Reiter's syndrome, mouth and genital ulcers with inflamed cartilage syndrome, cyclic neutropenia, and autoinflammatory diseases (familial Mediterranean fever, periodic fever, aphthous ulcers, pharyngitis, adenopathy, hyperimmunoglobulinemia D).…”

Raised concentration of soluble form of vascular endothelial cadherin and IL-23 in sera of patients with Behçet’s disease

“…All selected patients had aphthous lesions with at least two other clinical manifestations, such as genital ulcer, skin lesion (erythema nodosum, papulopustular lesion, folliculitis), positive pathergy reaction or ocular diseases (anterior or posterior uveitis). Disease activity was determined according to clinical signs and ranged from 1 to 3 (mild), 4 to 6 (moderate), and 7 to 9 (severe) according to Kruse et al [16,17]. The control group consisted of 44 healthy age-and sex-matched volunteers with no history of autoimmunity or significant severe infection at the time of sampling.…”