Recurrent Bilateral Anterior Uveitis with Kikuchi–Fujimoto Disease

Gómez-Mariscal, M; Oleñik, Andrea; Arriba-Palomero, Pablo; García‐Cosío, Mónica; Muñoz‐Negrete, Francisco J.

doi:10.1080/09273948.2016.1188966

Cited by 5 publications

(1 citation statement)

References 15 publications

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“…Celiac disease [34] Systemic lupus erythematosus, systemic vasculitides (Kawasaki disease, polyarteritis nodosa, granulomatosis with polyangiitis, giant cell arteritis) Monogenic autoinflammatory diseases: Blau syndrome, cryopyrine-associated periodic syndromes, A20 haploinsufficiency [35] Common variable immunodeficiency [36] IgG4-related disease [37] Kikuchi-Fujimoto disease [38] Sweet's syndrome [39] Autoimmune lymphoproliferative syndrome [40]…”

Section: Hla-b27-associated Uveitis/spondyloarthritismentioning

confidence: 99%

Uveitis as an Open Window to Systemic Inflammatory Diseases

Jammal

Loria

Jamilloux

et al. 2021

JCM

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Spondyloarthritis (Spa), Behçet’s disease (BD) and sarcoidosis are major systemic inflammatory diseases worldwide. They are all multisystem pathologies and share a possible ocular involvement, especially uveitis. We hereby describe selected cases who were referred by ophthalmologists to our internal medicine department for unexplained uveitis. Physical examination and/or the use of laboratory and imaging investigations allowed to make a diagnosis of a systemic inflammatory disease in a large proportion of patients. In our tertiary referral center, 75 patients have been diagnosed with Spa (n = 20), BD (n = 9), or sarcoidosis (n = 46) in the last two years. There was a significant delay in the diagnosis of Spa-associated uveitis. Screening strategies using Human Leukocyte Antigen (HLA)-B27 determination and sacroiliac magnetic resonance imaging in patients suffering from chronic low back pain and/or psoriasis helped in the diagnosis. BD’s uveitis affects young people from both sexes and all origins and usually presents with panuveitis and retinal vasculitis. The high proportion of sarcoidosis in our population is explained by the use of chest computed tomography (CT) and 18F-fluorodeoxyglucose positron emission tomography CT that helped to identify smaller hilar or mediastinal involvement and allowed to further investigate those patients, especially in the elderly. Our results confirm how in these sight- and potentially life-threatening diseases a prompt diagnosis is mandatory and benefits from a multidisciplinary approach.

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Section: Hla-b27-associated Uveitis/spondyloarthritismentioning

confidence: 99%

Uveitis as an Open Window to Systemic Inflammatory Diseases

Jammal

Loria

Jamilloux

et al. 2021

JCM

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Kikuchi-Fujimoto disease associated optic neuropathy in an adolescent

Cheong,

Nayer,

Odel

2025

American Journal of Ophthalmology Case Reports

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Kikuchi–Fujimoto disease triggered by Salmonella enteritidis in a child with concurrent auto-immune thyroiditis and papilloedema

Açoğlu

Sarı

Şahin

et al. 2018

Paediatrics and International Child Health

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Kikuchi-Fujimoto disease (KFD) is a histiocytic necrotising lymphadenitis characterised by painful cervical lymphadenopathy, fever, malaise and weight loss. Infections, auto-immune pathogenesis and a genetic association have been implicated. A 12-year-old boy presented with a 1-month history of fever, abdominal pain, constipation and weight loss, and a painful lymph node was detected in the right axilla. Chest CT demonstrated multiple lymph nodes, especially in the left mediastinum. Salmonella enteritidis group D was detected in a blood culture and he was treated with ceftriaxone, followed by meropenem. An axillary lymph node biopsy demonstrated necrotising histiocytic lymphadenitis and KFD was diagnosed. He was discharged 35 days after admission. He was re-admitted 3 weeks later with recurrence of symptoms and headache and was found to have papilloedema of the left eye and auto-immune thyroiditis. Intravenous immunoglobulin (IVIG) 400 mg/kg/day was administered for 5 days. The fever and papilloedema slowly resolved and, subsequently, the thyroiditis, and he has remained well on follow-up. This is the first report of an association of S. enteritidis infection and papilloedema with KFD. IVIG may be required in prolonged or recurrent cases and in those with an auto-immune association.

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Recurrent Bilateral Anterior Uveitis with Kikuchi–Fujimoto Disease

Abstract: Additional reported cases are required to better understand the Kikuchi-Fujimoto disease and the pathogenesis and features of its ocular involvement.

Cited by 5 publications

References 15 publications

Uveitis as an Open Window to Systemic Inflammatory Diseases

Uveitis as an Open Window to Systemic Inflammatory Diseases

Kikuchi-Fujimoto disease associated optic neuropathy in an adolescent

Kikuchi–Fujimoto disease triggered by Salmonella enteritidis in a child with concurrent auto-immune thyroiditis and papilloedema

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