Recurrent community-acquired Clostridium(Clostridioides)difficile infection in Serbianchildren

Stojanović, Predrag; Kuijper, Ed J.; Stojanović, Nenad; Vendrik, Karuna E.W.; Niko, Radulović

doi:10.1007/s10096-019-03751-4

Cited by 8 publications

(2 citation statements)

References 40 publications

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“…36, 37 Although PaLoc has several characteristics of mobile genetic elements, it appears immobile within every toxigenic C. difficile types. [36][37][38][39][40][41] TcdA and TcdB are in clostridial glycosylation toxin group, also as well as lethal toxin (TcsL), and also hemorrhagic toxin (TcsH) in Clostridium sordellii, alpha toxin (TcnA) in Clostridium perfringens large cytotoxin TpeL. 21 The size of the toxin is huge, 250 and 308 kDa, with a high degree of sequence identity.…”

Section: Virulence Factors Of C Difficilementioning

confidence: 99%

Clostridium difficile virulence factors as the cause of antibiotic-associated diarrhea (AAD): a literature review

2022

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Clostridium difficile is an anaerobic gram-positive bacillus, capable of forming spores and toxins, transmitted to humans by the faecal-oral route C. difficile infection (CDI) is recognized as a typical cause of healthcare-associated infections (HAIs) and contributes to a significant proportion of morbidity and mortality of hospitalized patients. C. difficile culture and toxin examinations are still minimal in many hospitals in various Asian countries. As a result, reports of C. difficile in Asia are still rare, while reports of cases of CDI in Indonesia are still rare. Several risk factors including advanced age, antibiotic exposure, and hospitalization are strongly associated with CDI. C. difficile has the ability to colonize the large intestine, then release exotoxin proteins (TcdA, TcdB) causing colitis in people with risk factors. A diagnosis of suspected C. difficile infection in a patient with diarrhea without a clear alternative explanation, with relevant risk factors (including long antibiotic consumption, hospitalization events, and elderly age), was then performed microbiological examination to carry out proper management and control of infection. This study aims to review C. difficile virulence factors as the cause of antibiotic-associated diarrhea.

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Section: Virulence Factors Of C Difficilementioning

confidence: 99%

Clostridium difficile virulence factors as the cause of antibiotic-associated diarrhea (AAD): a literature review

2022

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“…Как известно, CDI развивается прежде всего у лиц из групп высокого риска, с иммунодефицитными состояниями и находящихся в условиях госпитализации или в закрытых учреждениях долгосрочного ухода [8]. Пациенты детского онкологического стационара совмещают в себе несколько факторов риска развития CDI: лейкоз как основное заболевание, лечение иммунодепрессантами и/или цитостатиками и лечение антибиотиками [9].…”

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Clostridium difficile infection in the pediatric patients of an oncological hospital: cultivation of anaerobic intestinal flora and treatment

Швыдкая

Джандарова

Митрохин

2021

Microbiology Independent Research Journal (MIR Journal)

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In recent years, the number of infectious diseases caused by Clostridium difficile in the world has grown with a significant increase in relapses and mortality in patients, particularly among the cancer patients in hospitals. There is also observed an increase in the resistance of Clostridium difficile to the first-line drugs, namely metronidazole and vancomycin, which makes the search for new methods of treatment and prevention of this infection even more urgent. In this review, we analyze the recent data on the methods of cultivation and isolation of the pure bacterial culture of Clostridium difficile and other anaerobic enteropathogens over the course of enterocolitis treatment with antimicrobial drugs in pediatric patients with oncopathology. Novel approaches to the therapy of this infection are discussed.

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Community-onset Clostridioides difficile infection in south Serbia

Stojanović

Harmanus²,

Kuijper³

2023

Anaerobe

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Recurrent community-acquired Clostridium(Clostridioides)difficile infection in Serbianchildren

Cited by 8 publications

References 40 publications

Clostridium difficile virulence factors as the cause of antibiotic-associated diarrhea (AAD): a literature review

Clostridium difficile virulence factors as the cause of antibiotic-associated diarrhea (AAD): a literature review

Clostridium difficile infection in the pediatric patients of an oncological hospital: cultivation of anaerobic intestinal flora and treatment

Community-onset Clostridioides difficile infection in south Serbia

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