Recurrent exposure to ferric oxide nanoparticles alters myocardial oxidative stress, apoptosis and necrotic markers in male mice

Manickam, Vijayprakash; Periyasamy, Madhivadhani; Vasanth, D.; Panneerselvam, Lakshmikanthan; Perumal, Ekambaram

doi:10.1016/j.cbi.2017.10.003

Cited by 34 publications

(23 citation statements)

References 54 publications

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“…On the other hand, it has been shown that high levels of ROS can cause damage to macromolecules . The results of our study are in agreement with previous studies …”

Section: Discussionsupporting

confidence: 94%

“…It has been shown that the surface area of NPs plays an important role in the generation of ROS . Also, one of the most important mechanisms of toxicity due to NPs is the generation of ROS . We have shown that exposure to Fe 2 O 3 NPs in a dose and time‐dependent pattern leads to an increase in the level of ROS in human lymphocytes.…”

Section: Discussionmentioning

confidence: 80%

“…Despite widespread use, there are many concerns about the risk of human exposure to NPs. NPs, due to their small size and high reactivity, easily enter the body via different routes . Studies have highlighted concerns about the risk of exposure of living organisms to Fe 2 O 3 NPs .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…We have shown that exposure to Fe 2 O 3 NPs in a dose and time‐dependent pattern leads to an increase in the level of ROS in human lymphocytes. Previous studies have shown that metal oxide NPs such as Fe 2 O 3 NPs are capable of generating ROS (as a maim mechanism) through Fenton's reaction . Studies show that mitochondria are one of the sources of cellular ROS generation .…”

Section: Discussionmentioning

confidence: 99%

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Toxicity of Fe₂O₃ nanoparticles on human blood lymphocytes

Assadian

Dezhampanah

Seydi

et al. 2019

J Biochem & Molecular Tox

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Magnetic nanoparticles (NPs) are used to a large extent in the targeted delivery of therapeutic agents. In this study, we aimed to investigate the possible toxicity of Fe 2 O 3 NPs on human cells, including blood lymphocytes. We isolated blood lymphocytes from healthy humans using Ficoll polysaccharide and subsequently by gradient centrifugation. Then, the toxicity parameters, including cell viability, reactive oxygen species (ROS) formation, lipid peroxidation, cellular glutathione (GSH) level, mitochondrial and lysosomal damage, were measured in blood lymphocytes after J Biochem Mol Toxicol. 2019;33:e22303.wileyonlinelibrary.com/journal/jbt

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“…On the other hand, it has been shown that high levels of ROS can cause damage to macromolecules . The results of our study are in agreement with previous studies …”

Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Toxicity of Fe₂O₃ nanoparticles on human blood lymphocytes

Assadian

Dezhampanah

Seydi

et al. 2019

J Biochem & Molecular Tox

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Research progress on toxicity, function, and mechanism of metal oxide nanoparticles on vascular endothelial cells

Wang

Tang

2020

J of Applied Toxicology

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Metal oxide nanoparticles present stable and unique performance that makes them suitable for various biomedical applications. There are four common exposure ways that nanoparticles enter our body: injection, inhalation, skin penetration, and ingestion. Among them, injection, ingestion, and skin routes may become significant ways for nano‐scale treatment and cosmetics, and inhalation is the essential way for occupational exposure. All those nanoparticles could pass through the exposure routes and enter the circulation, which could cause damage on the cardiovascular system. So it is necessary to evaluate the toxicity of metal oxide nanoparticles and to explore the mechanism. This review chose four commonly used nanometal oxides to discuss about the toxicity they produced, the function they affected, and the mechanisms on cardiovascular endothelial cells. First, we discussed the toxicity they caused. These nanoparticles are less toxic when applied in low doses, but owing to the small particle size and large specific surface area, acute exposure or the metal ions released by nanoparticles will lead to phenotypic changes of endothelial cells, oxidative stress, and apoptosis. An endothelial cell is an essential part of blood vessels and could act as a barrier, maintain vascular tension, and keep the balance between coagulation and anticoagulation. Once vascular endothelium is injured or exposed to vascular risk factors, it would cause endothelial activation, endothelial dysfunction, and nitric oxide (NO) synthase (NOS) dysfunction, which are closely related to the cardiovascular disease. Finally, we talked about the mechanisms by four levels, and we especially mentioned inflammation, the production of reactive oxygen species, and NO.

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Di(2‐ethylhexyl) phthalate and microplastics cause necroptosis and apoptosis in hepatocytes of mice by inducing oxidative stress

Chen

Zhang

et al. 2023

Environmental Toxicology

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Di(2‐ethylhexyl) phthalate (DEHP) is a plasticizer and an endocrine disruptor. Microplastics (MPs) are pathogenic small plastic particles and abundant in the aqueous environment. The problem of residual hazards of plastic products is worthy of study, especially the joint exposure of a variety of plastic‐related products to the toxic effect. We used 200 mg/kg DEHP and 10 mg/L MPs to establish exposure model in vivo and 2 mM DEHP and 200 μg/L MPs to establish AML12 cell exposure model in vitro. In vivo study results showed that compared with the control group (NC) group, DEHP and MPs significantly increased the contents of malondialdehyde and hydrogen peroxide, and significantly decreased the contents of glutathione and the activity of superoxide dismutase, total antioxidant capacity, catalase and glutathione peroxidase. The level of oxidative stress was further aggravated after combined exposure. The reactive oxygen species level of AML12 exposed to DEHP and MPs in vitro was significantly higher than NC group, and the combined exposure was significantly higher than the single exposure. The in vivo and in vitro also confirmed that DEHP and MPs could significantly increase the mRNA and protein levels of apoptosis markers and necroptosis markers and there was an additive effect. After N‐acetylcysteine treatment in vitro, the above‐mentioned oxidative stress level and cell damage decreased significantly. This study provided a reference for advocating the reduction of the mixed use of plastic products, and provided a basis for preventing the harm of plastic products residues.

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Recurrent exposure to ferric oxide nanoparticles alters myocardial oxidative stress, apoptosis and necrotic markers in male mice

Cited by 34 publications

References 54 publications

Toxicity of Fe₂O₃ nanoparticles on human blood lymphocytes

Toxicity of Fe₂O₃ nanoparticles on human blood lymphocytes

Research progress on toxicity, function, and mechanism of metal oxide nanoparticles on vascular endothelial cells

Di(2‐ethylhexyl) phthalate and microplastics cause necroptosis and apoptosis in hepatocytes of mice by inducing oxidative stress

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Recurrent exposure to ferric oxide nanoparticles alters myocardial oxidative stress, apoptosis and necrotic markers in male mice

Cited by 34 publications

References 54 publications

Toxicity of Fe2O3 nanoparticles on human blood lymphocytes

Toxicity of Fe2O3 nanoparticles on human blood lymphocytes

Research progress on toxicity, function, and mechanism of metal oxide nanoparticles on vascular endothelial cells

Di(2‐ethylhexyl) phthalate and microplastics cause necroptosis and apoptosis in hepatocytes of mice by inducing oxidative stress

Contact Info

Product

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About

Toxicity of Fe₂O₃ nanoparticles on human blood lymphocytes

Toxicity of Fe₂O₃ nanoparticles on human blood lymphocytes