Recurrent familial hydatidiform mole - a rare clinical problem

Rai, Lavanya; Hebbar, Shripad; Guruvayare, Shyamala; Adiga, Prashant; Sunil, Anjali

doi:10.5152/jtgga.2012.48

Cited by 4 publications

(1 citation statement)

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“…Preimplantation confirmation of diploidy by FISH also avoids the selection of triploid PHMs that may result from mechanisms other than dispermic fertilisation [28]. In cases of diploid biparental moles that do not contain excess of paternally inherited genetic material, but have mutations in NLRP7 or KHDC3L genes that disrupt normal imprinting and have been associated with a defect in the epigenetic status of the oocyte genome, oocyte donation should be mainly considered in order to achieve normal pregnancy [19,[29][30][31]. This strategy was encouraged for our patient too, who is now considering oocyte donation as the most preferable management in order to achieve pregnancy.…”

Section: Rhms Is Not An Endless Condition: Reproductive Options In Favour Of a Normal Pregnancymentioning

confidence: 99%

Recurrent complete hydatidiform mole: where we are, is there a safe gestational horizon? Opinion and mini-review

Kalogiannidis

Kalinderi

Kalinderis

et al. 2018

J Assist Reprod Genet

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Benign hydatidiform mole, complete or partial, is the most common type of gestational trophoblastic disease (GTD) characterised by excessive trophoblastic proliferation and abnormal embryonic development. Although most complete hydatidiform moles (CHMs) are diploid androgenetic, a few cases of CHMs are biparental, characterised by recurrence and familial clustering. In these rare cases, mutations in NLRP7 or KHDC3L genes, associated with maternal imprinting defects, have been implicated. Current data regarding future pregnancy options in hydatidiform moles are discussed and our opinion is presented based on an incidence that took place in our hospital with a woman with consecutive molar pregnancies. In recurrent hydatidiform moles, DNA testing should be performed and when NLRP7 or KHDC3L mutation are detected, oocyte donation should be proposed as an option to maximise woman's chances of having a normal pregnancy.

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