Recurrent Glomerulonephritis After Kidney Transplantation

Choy, Bo Ying; Chan, Tak Mao; Lokesh, K N

doi:10.1111/j.1600-6143.2006.01502.x

Cited by 189 publications

(148 citation statements)

References 64 publications

(120 reference statements)

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“…These patients are at risk of recurrence of the underlying disease and graft loss. The new immunosuppressive medications influence the rate of acute rejection as well as reduce the chronic allograft nephropathy [24]. The study of Briganti et al comprising a total of 1505 patients with performed biopsy of the native and transplanted kidney demonstrated that recurrent GN as a cause of graft loss is on the third place of all defined causes.…”

Section: Discussionmentioning

confidence: 99%

Monitoring of Renal Allograft Function with Different Equations: What are the Differences?

Bushljetikj¹,

Selim²,

Taneva³

et al. 2017

BANTAO Journal

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Introduction. Monitoring of graft function by creatinine concentrations in serum and calculated glomerular filtration rate (GFR) is recommended after kidney transplantation. KDIGO recommendations on the treatment of transplant patients advocate usage of one of the existing mathematical equations based on serum creatinine. We compared clinical application of three equations based on serum creatinine in monitoring the function of transplanted kidney. Methods. A total number of 55 adult patients who received their first renal allograft from living donors at our transplant center in between 2011-2014 were included into the study. Renal allograft GFR was estimated by the Cockroft-Gault, Nankivell and MDRD formula, and correlated with clinical parameters of donors and recipients. Results. The mean age of recipients was 35.7±9.5 (range 16-58), and the mean age of donors was 55.5±9.0 (34-77) years. Out of this group of 55 transplant patients, 50(90.91%) were on hemodialysis (HD) prior to transplantation. HD treatment was shorter than 24 months in 37(74%) transplant patients. The calculated GFR with MDRD equation showed the highest mean value at 6 and 12 months (68.46±21.5; 68.39±24.6, respectively) and the lowest at 48 months (42.79±12.9). According to the Cockroft&Gault equation GFR was the highest at 12 months (88.91±24.9) and the lowest at 48 months (66.53±18.1 ml/min). The highest mean level (80.53±17.7) of the calculated GFR with the Nankivell equation was obtained at 12 months and the lowest (67.81±16.7 ml/min) at 48 months. The values of Pearson's correlation coefficient between the calculated GFR and the MDRD at 2 years after transplantation accor-

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Section: Discussionmentioning

confidence: 99%

Monitoring of Renal Allograft Function with Different Equations: What are the Differences?

Bushljetikj¹,

Selim²,

Taneva³

et al. 2017

BANTAO Journal

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“…Still, too many patients proceed to transplant without a formal diagnosis of their kidney disease, thus limiting the opportunity to improve our knowledge about potentially recurrent diseases and the chance to better treat recipients at risk of recurrence. 5,10,11 Early referral to a nephrologist and prompt histologic evaluation of the kidney are key factors and should be strongly promoted by the transplant community.…”

Section: Discussionmentioning

confidence: 99%

“…As a consequence, we are conducting an increased number of transplant procedures for recipients with a primary kidney disease that is resistant to standard immunosuppressive protocols. 5,6,[13][14][15] If such an aggressive disease recurs after transplant, a poor prognosis should be expected and alternative treatments considered as soon as a formal diagnosis is available. 5,6,10,[13][14][15][16][17][18] Our study was retrospective in nature and had a relatively small sample size.…”

Section: Discussionmentioning

confidence: 99%

“…2 Several studies have investigated how the cause of terminal renal failure might actually affect outcomes after transplant, but most of these were performed more than 10 years ago, used third-party databases, or only focused on primary and secondary glomerulonephritis. [3][4][5][6] It is well known that primary and secondary glomerulonephritis often recurs after transplant and can negatively affect graft survival. [3][4][5][6] Nevertheless, many other diseases can virtually recur after transplant, but their long-term effects on transplant outcomes remain unclear.…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5][6] It is well known that primary and secondary glomerulonephritis often recurs after transplant and can negatively affect graft survival. [3][4][5][6] Nevertheless, many other diseases can virtually recur after transplant, but their long-term effects on transplant outcomes remain unclear. 7,8 The main reason is that clinical studies evaluating recurrent primary kidney diseases in renal transplant recipients generally include only a limited number of cases.…”

Section: Introductionmentioning

confidence: 99%

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Favi

Pedroso²,

Salerno³

et al. 2018

Exp Clin Transplant

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Objectives: Recurrent glomerulonephritis can negatively affect kidney allograft survival. However, how primary renal disease affects transplant outcomes in the new era of immunosuppression remains unclear. Materials and Methods: We categorized 426 kidney transplant recipients (performed from 1996 to 2007) into 4 disease groups: (1) 99 recipients with biopsyproven immunologically mediated kidney disease, (2) 40 recipients with urologic disease, (3) 67 recipients with polycystic kidney disease, and (4) 220 recipients with other causes of terminal renal failure/uncertain kidney disease. Long-term transplant outcomes were compared between groups at 1, 5, and 10 years of follow-up. Results: Compared with the urologic, polycystic, and other diseases groups, the immunologic group showed significantly lower time of graft survival (9.5 ± 4 vs 8 ± 4 vs 8.5 ± 4 vs 7 ± 4 years, respectively) and estimated glomerular filtration rate (52.5 ± 32 vs 49 ± 22 vs 50 ± 32 vs 35.5 ± 30 mL/min; P < .05). Relative risk of 10-year graft loss for the immunologic group was 2.8 (95% confidence interval, 1.6-4.9). Recurrence rate was 12% in the immunologic group versus 1% and 0% in the other diseases and remaining groups (P < .05). The relative risk of 10-year graft loss for patients with recurrence was 2.7 (95% confidence interval, 1.2-6.3). Ten-year graft loss rates for patients with biopsy-proven acute rejection, chronic allograft nephropathy, and recurrent glomerulonephritis were 30%, 23%, and 42% (P < .05). For those with biopsyproven recurrent glomerulonephritis, 10-year estimated glomerular filtration rate was significantly lower than for those with biopsy-proven acute rejection or chronic allograft nephropathy (14 ± 6 vs 18 ± 7 vs 30 ± 10 mL/min; P < .05). Conclusions: Kidney transplant recipients with immunologically mediated kidney diseases have inferior long-term allograft survival and function versus patients with other causes of renal failure. Recurrence represents the strongest risk factor for premature loss of function and transplant failure.

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Assessment of the Potential Renal Transplant Recipient

Mark

Jardine

2012

Handbook of Renal and Pancreatic Transplantation

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Recurrent Glomerulonephritis After Kidney Transplantation

Cited by 189 publications

References 64 publications

Monitoring of Renal Allograft Function with Different Equations: What are the Differences?

Monitoring of Renal Allograft Function with Different Equations: What are the Differences?

Untitled

Assessment of the Potential Renal Transplant Recipient

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