Recurrent idiopathic iridocyclitis after autologous peripheral blood stem-cell transplantation followed by G-CSF administration for acute lymphoblastic leukemia

Tsuchiyama, Junjiro; Imajo, Kento; Sakaguchi, N.; Yoshino, Tadashi; Suzaki, Noriyuki; Kondo, Eisei; Kawata, Naomi; Okada, Kouhei; Maeda, Tomoya; Tomiyama, Yoshiaki; Tsubota, Teruhiko

doi:10.1007/s002770050591

Cited by 6 publications

(3 citation statements)

References 11 publications

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“…27,28 Administration of G-CSF to patients can induce or exacerbate preexisting inflammatory conditions, including uveitis. 29,30 We have previously reported that G-CSFedeficient mice are resistant to collagen-induced arthritis. 31 Wild-type (WT) mice treated with antieG-CSF also had reduced collagen-induced arthritis, even when antieG-CSF was administered therapeutically.…”

mentioning

confidence: 99%

G-CSF and Neutrophils Are Nonredundant Mediators of Murine Experimental Autoimmune Uveoretinitis

Goldberg

Cornish

Murphy

et al. 2016

The American Journal of Pathology

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Granulocyte colony-stimulating factor (G-CSF) is a regulator of neutrophil production, function, and survival. Herein, we investigated the role of G-CSF in a murine model of human uveitis-experimental autoimmune uveoretinitis. Experimental autoimmune uveoretinitis was dramatically reduced in G-CSF-deficient mice and in anti-G-CSF monoclonal antibody-treated, wild-type (WT) mice. Flow cytometric analysis of the ocular infiltrate in WT mice with experimental autoimmune uveoretinitis showed a mixed population, comprising neutrophils, macrophages, and T cells. The eyes of G-CSF-deficient and anti-G-CSF monoclonal antibody-treated WT mice had minimal neutrophil infiltrate, but no change in other myeloid-derived inflammatory cells. Antigen-specific T-cell responses were maintained, but the differentiation of pathogenic type 17 helper T cells in experimental autoimmune uveoretinitis was reduced with G-CSF deficiency. We show that G-CSF controls the ocular neutrophil infiltrate by modulating the expression of C-X-C chemokine receptors 2 and 4 on peripheral blood neutrophils, as well as actin polymerization and migration. These data reveal an integral role for G-CSF-driven neutrophil responses in ocular autoimmunity, operating within and outside of the bone marrow, and also identify G-CSF as a potential therapeutic target in the treatment of human uveoretinitis.

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confidence: 99%

G-CSF and Neutrophils Are Nonredundant Mediators of Murine Experimental Autoimmune Uveoretinitis

Goldberg

Cornish

Murphy

et al. 2016

The American Journal of Pathology

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“…Noninfectious inflammatory eye diseases (uveitis, iritis, iridocyclitis, chorioretinitis, scleritis, conjunctivitis) can occur as an isolated manifestation of an autoimmune disease in association with systemic diseases (eg, arthritis, connective tissue diseases, Behçet disease), as a result of a trauma, or as a side effect of medications. HSC donation is generally not recommended during an acute inflammatory process because uveitis has been reported as an adverse event after G-CSF administration [42,43]. In the presence of systemic disease suitability has to be assessed accordingly.…”

Section: Eligibility Criteria In Noninfectious Eye Diseasesmentioning

confidence: 99%

Suitability Criteria for Adult Related Donors: A Consensus Statement from the Worldwide Network for Blood and Marrow Transplantation Standing Committee on Donor Issues

Worel

Buser

Greinix

et al. 2015

Biology of Blood and Marrow Transplantation

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The number of allogeneic hematopoietic stem cell (HSC) transplants performed globally each year continues to increase. Advances in HLA typing, better supportive care, and administration of reduced-intensity conditioning regimens allow treatment of older patients with older sibling donors. Pretransplant donor assessment and testing are very important processes affecting the quality and safety of donation. For unrelated HSC donors detailed recommendations for health assessment have been published, allowing donation only if they are unrestrictedly healthy. Eligibility criteria for related donors are less strict and vary significantly between centers. In situations where a family donor does not meet the suitability criteria for unrelated donors, involved physicians often struggle with the decision whether the matched relative is suitable for donation or not. On behalf of the Worldwide Network for Blood and Marrow Transplantation Standing Committee on Donor Issues, we intended to develop a consensus document with recommendations for donor workup and final clearance of family donors who would not be able to serve as unrelated donors because of their age or pre-existing diseases. This article covers different topics intending to support decision-making, with the goal of minimizing medical risk to the donor and protection of the recipient from transmissible diseases.

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“…Few reports exist about HIV negative immunodepressed individuals who suffered from immune recovery uveitis [1]. IRU occurred in these eyes after tapering of chemotherapy for non-Hodgkin's lymphoma, renal transplantation or even after administration of granulocyte colony stimulating factor [2,3]. Kuo et al reported the largest case series of IRU in 18 individuals with CMV retinitis outside the HIV setting [4].…”

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confidence: 99%

Immune Recovery Uveitis Occurring after Chemotherapy and Ocular CMV Infection in Chronic Lymphatic Leukaemia

Wimmersberger

Balaskas²,

Gander³

et al. 2011

Klin Monatsbl Augenheilkd

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Recurrent idiopathic iridocyclitis after autologous peripheral blood stem-cell transplantation followed by G-CSF administration for acute lymphoblastic leukemia

Cited by 6 publications

References 11 publications

G-CSF and Neutrophils Are Nonredundant Mediators of Murine Experimental Autoimmune Uveoretinitis

G-CSF and Neutrophils Are Nonredundant Mediators of Murine Experimental Autoimmune Uveoretinitis

Suitability Criteria for Adult Related Donors: A Consensus Statement from the Worldwide Network for Blood and Marrow Transplantation Standing Committee on Donor Issues

Immune Recovery Uveitis Occurring after Chemotherapy and Ocular CMV Infection in Chronic Lymphatic Leukaemia

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