Recurrent IgA Nephropathy in a Renal Allograft Presenting as Crescentic Glomerulonephritis

Recurrent or De Novo IgA Nephropathy with Crescent Formation after Renal Transplantation

“…These patients with recurrent IgA nephropathy often presented crescent formation in histology with rapidly progressive renal failure. [9][10][11][12] In this study, we found that our patients had no response or just short time response to intensive immunosuppressive therapy. All of our patients changed their initial immunosuppressive regimens; however, six advanced to renal graft loss within 2 to 12 months, three of them eventually developed ESRD and returned to hemodialysis therapy within two years after kidney transplantation, and only one kept stable graft function for more than three years of follow-up.…”

“…[9][10][11][12] We reported 10 cases that were diagnosed as recurrent or de novo IgA nephropathy with crescent formation. They aged from 25 to 65 years old, and 80% were male.…”

“…[8] Though rare, patients with recurrent IgA nephropathy can present with rapidly progressive glomerulonephritis and subsequent graft loss, characterized by a various degree of crescent formation in histological examination. [9][10][11][12] In this study, we retrospectively analyzed our ten kidney transplanting patients who had renal biopsy proven IgA nephropathy with a different degree of crescentic formation in order to investigate their clinical and pathological features and renal outcome. on those 1,000 recipients.…”

Segmental glomerulosclerosis in IgA nephropathy after renal transplantation: relationship with proteinuria and therapeutic response to enalapril

“…The presence of a crescent may be a sign of glomerular capillaritis (30) associated with capillary loop deposits and could be an integral part of glomerulonephritic injury. As crescentic forms of recurrent IgAN, with rapidly progressive courses, have been occasionally reported (31,32), the identification of the initiating or triggering factors for crescent formation may be of importance. Among the histological parameters, the presence of SS was related to proteinuria, and this was more definite when cases were limited to nephrotic range proteinuria: 21 of the 29 patients with 1 g/24 h or more of proteinuria showed SS, whereas nine of the 11 patients with nephrotic range proteinuria showed this feature.…”

Live donor renal transplantation in patients with end‐stage renal failure due to IgA nephropathy: clinicopathological assessment

“…Recurrent IgAN in the graft was initially thought to be a benign process because transplant dysfunction or graft loss secondary to recurrent IgAN was infrequent 1,4 , 14 . However, a few were reported to manifest as rapidly progressive GN or crescentic GN, resulting in early or rapid graft failure 16–19 . Recent studies have raised arguments that recurrent IgAN could play a significant negative impact on the graft function and survival in long‐term survivors, and that long‐term graft survival is independent of the different kinds of primary renal disease.…”