Segmental glomerulosclerosis in IgA nephropathy after renal transplantation: relationship with proteinuria and therapeutic response to enalapril

Jeong, Hyeon Joo; Kim, Yu Seun; Kwon, Kye Won; Kim, Myoung Soo; Kim, Soon Il; Choi, Kyu Hun; Lee, Ho Yung; Han, Dae Suk; Park, Kiil

doi:10.1034/j.1399-0012.2003.02067.x

Cited by 11 publications

(7 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…11 With the limited information on recurrent IgAN, we previously conducted a study of post-transplant IgAN (TxIgAN), incorporating glomerular mesangial IgA deposits irrespective of original disease confirmation, to reveal histological features associated with proteinuria. The current study showed an association between proteinuria and segmental glomerulosclerosis, 12 which was in accord with a study from Japan. 13 However, in contrast to their study which revealed no crescents, 13 glomerular crescents were found in renal allograft biopsies in four of 54 patients at an average of 46 months post-transplant, and they all accompanied urinary abnormality.…”

supporting

confidence: 92%

“…13 However, in contrast to their study which revealed no crescents, 13 glomerular crescents were found in renal allograft biopsies in four of 54 patients at an average of 46 months post-transplant, and they all accompanied urinary abnormality. 12 The aim of the present study was to examine the prevalence and significance of glomerular crescents in chronic graft dysfunction of TxIgAN patients.…”

mentioning

confidence: 98%

See 1 more Smart Citation

Glomerular crescents are responsible for chronic graft dysfunction in post‐transplant IgA nephropathy

Jeong

Kim

Kwon

et al. 2004

Pathology International

Self Cite

View full text Add to dashboard Cite

Information is limited regarding the histological features related to chronic graft dysfunction and failure in patients with IgA nephropathy developing after renal transplantation. The prevalence and significance of glomerular crescents in post-transplant IgAN including recurrent, de novo and transmitted forms (TxIgAN), were studied. Renal morphology was evaluated in 71 patients of TxIgAN, obtained at more than 6 months post-transplant, and compared with regard to the presence (C-TxIgAN) or absence (N-TxIgAN) of glomerular crescents. Crescents were demonstrated in 12 samples of 10 patients (14.1%). The percentages of crescents were from 4.8% to 83.3% (median, 28.6%) in each sample. Ten samples of C-TxIgAN had cellular to fibrocellular crescents, and four of these were associated with diffuse mesangial proliferation. Serum creatinine levels and the frequency of nephrotic range proteinuria at the time of biopsy and the degree of interstitial inflammation were significantly different in the two groups. Graft survival after allograft biopsies was significantly lower in C-TxIgAN (P = 0.0017). Chronic rejection was a major cause of graft loss in N-TxIgAN (31.8%), whereas TxIgAN was the major cause in C-TxIgAN (66.7%). In conclusion, the current study suggests that glomerular crescents are not rare and that they are responsible for chronic graft dysfunction in TxIgAN patients.

show abstract

supporting

confidence: 92%

mentioning

confidence: 98%

Glomerular crescents are responsible for chronic graft dysfunction in post‐transplant IgA nephropathy

Jeong

Kim

Kwon

et al. 2004

Pathology International

Self Cite

View full text Add to dashboard Cite

show abstract

“…The presence of segmental sclerosis but not mesangial proliferation was associated with proteinuria of 1 g or more per 24 h in recurrent samples. Considering the average time to posttransplantation biopsy (3.6 years) and the low prevalence of chronic rejection, it seems that glomerular hypertrophy [23] and segmental glomerulosclerosis are major factors in the development of proteinuria in patients with recurrent IgAN. Of recurrent IgAN patients, 63.6% were treated with angiotensin-converting enzyme inhibitors or receptor blockers at the time of biopsy, which could have affected urinary protein excretion [21,24].…”

Section: Discussionmentioning

confidence: 99%

Progression of renal allograft histology after renal transplantation in recurrent and nonrecurrent immunoglobulin A nephropathy

et al. 2008

Self Cite

View full text Add to dashboard Cite

“…Little information is available about therapeutic trials in patients with post‐transplant IgAGN recurrence. Some investigators (36, 37) found an important antiproteinuric effect of ACE inhibitors in IgAGN transplant recipients. As proteinuria is considered an important marker of progression in transplant patients with IgAGN (38), it is possible to speculate that ACE inhibitors and/or angiotensin receptor blockers could slow the progression of recurrent glomerulonephritis.…”

Section: Potential Treatments For Recurrent Igagnmentioning

confidence: 99%

Renal transplantation in patients with IgA mesangial glomerulonephritis

Ponticelli¹,

Traversi²,

Banfi³

2004

Pediatric Transplantation

113

View full text Add to dashboard Cite

Most patients with IgA nephritis are suitable candidates for renal transplantation. In about 33% of patients the disease may recur after transplantation, although there are differences in the various series because of the different criteria for biopsy, the different length of follow-up and the different ethnicities. Living donation, genetic factors and time of progression of original disease have been found to be related with the risk of recurrence by some investigators, but these associations were not confirmed by other studies. The graft survival in patients with IgA nephritis is similar or even better than that observed with other renal diseases. The available data indicate that recurrence has a little impact on the 10-yr graft survival. However, a minority of patients may show a rapid progressive course after recurrence. Little information is available on the impact of recurrence in the very long term. There is no established treatment for preventing or treating the recurrence of IgA nephritis.

show abstract

Segmental glomerulosclerosis in IgA nephropathy after renal transplantation: relationship with proteinuria and therapeutic response to enalapril

Cited by 11 publications

References 30 publications

Glomerular crescents are responsible for chronic graft dysfunction in post‐transplant IgA nephropathy

Glomerular crescents are responsible for chronic graft dysfunction in post‐transplant IgA nephropathy

Progression of renal allograft histology after renal transplantation in recurrent and nonrecurrent immunoglobulin A nephropathy

Renal transplantation in patients with IgA mesangial glomerulonephritis

Contact Info

Product

Resources

About