Recurrent Ingrown Toenails Secondary to Indinavir/Ritonavir Combination Therapy

James, Christopher W.; McNelis, Kelly C; Cohen, David; Szabo, Susan; Bincsik, Arlene

doi:10.1345/aph.10386

Cited by 21 publications

(7 citation statements)

References 12 publications

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“…10), periungual fibroma in a lateral position, but also (amelanotic) melanoma and other malignant tumors (56) may cause ingrowing of the nail. Ingrown nails and granulation tissue mimicking them have also been observed after successful treatment of onychomycoses (57,58), under anti‐HIV therapy (59,60), and after oral retinoids (61). A thorough history is therefore mandatory, even in the seemingly banal case of ingrown nail.…”

Section: Ingrown Nailsmentioning

confidence: 99%

Ingrown and pincer nails: evaluation and treatment

Haneke¹

2002

Dermatol Ther

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Ingrown toenails are mainly a condition of children and young adults, whereas ingrown fingernail and pincer nails are seen in adults. Their etiology is multifactorial. Different types of ingrowing nails require different treatments. Neonatal ones are always treated conservatively. The hypertrophic lateral nail wall seldom requires surgery. Congenital misalignment of the big toenail may resolve spontaneously, but delay in treatment may cause permanent nail dystrophy. The juvenile type is most common and is treated conservatively in its early stages. Selective matrix horn phenolization or excision is the treatment of choice for later stages. Pincer nails are due to widening of the base of the distal phalanx. Treatment is aimed at reducing the outward pressure of the lateral osteophytes on the matrix horns and permanently flattening the nail. A variety of different methods are discussed.

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Section: Ingrown Nailsmentioning

confidence: 99%

Ingrown and pincer nails: evaluation and treatment

Haneke¹

2002

Dermatol Ther

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“…[14] Ingrown toenail and paronychia have been reported secondary to drugs, such as indinavir and indinavir/ritonavir combination. [15,16] Excess nail fold granulation tissue and ingrown toenail have also been reported with retinoids, [17] docetaxel, [18] cyclosporine [19] and oral antifungal treatment. [20] Subungual neoplasms may cause ingrown toenails due to compression of the nail plate against the nail fold.…”

Section: Predisposing Factorsmentioning

confidence: 99%

Ingrown toenails

Khunger¹,

Kandhari²

2012

Indian J Dermatol Venereol Leprol

127

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Onychocryptosis or ingrown toenail is a very common pathology of the toenail unit, chiefly affecting adolescents and young adults. The ingrown toenail is responsible for disabling complaints like pain and difficulty in walking. It is associated with significant morbidity, hampering the quality of life as it interferes with sporting activities, school, or work. It principally occurs in the hallux. It is ascribed to poor trimming of the nails in combination with local pressure due to ill-fitting footwear, hyperhidrosis, poor foot hygiene and nail abnormalities. Pain, swelling and discharge are the main clinical features. Four stages of the condition have been described. Diagnosis is usually evident, but it should be differentiated from subungual exostosis and tumors of the nail bed. The current standard of care focuses on conservative treatment like the gutter splint technique in the initial stages, and in cases that are resistant to medical management or recurrent, surgical correction is the treatment of choice. There are various surgical techniques that are described in literature. Although there is no ideal technique, lateral nail plate avulsion with lateral matricectomy by phenol is commonly used and reported to be more effective in reducing recurrences. The aim of this review article is to focus on this common pathology of the nail, the various techniques employed in management and aid in the selection of treatment according to the stage and severity of the disease.

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“…86,87 Retinoid-like effects are well established in indinavir-treated patients, including alopecia, chelitis, xerosis, and paronychia. [88][89][90][91][92] Garcia-Silvia et al 90 estimated that almost one-third of patients treated with indinavir developed at least two of these retinoid-like effects. 90 Indinavir has been shown to stimulate naturally occurring all trans-retinoic acid, and has been suggested to increase retinoid signaling pathways by decreasing the metabolism of retinoic acid.…”

Section: Indinavirmentioning

confidence: 99%