Recurrent Inhibition in the Olfactory Bulb: I. Effects of Antidromic Stimulation of the Lateral Olfactory Tract

Physiological evidence for two classes of mitral cells in the rat olfactory bulb

“…However, only a few studies have measured and reported the mean rate for the spontaneous activity; many more have examined a stimulus-evoked response and the spontaneous activity was estimated from a short pre-stimulus period. These previous estimates of spontaneous activity show a high degree of variability ranging from 0 to 42 spikes/sec (Green et al, 1962; Phillips et al, 1963; Mair, 1982; Shepherd, 1963; Yamamoto et al, 1963; Getchell & Shepherd, 1975; Chaput & Holley, 1980; Mori & Takagi, 1978; Harrison & Scott, 1986; Meredith, 1986; Chaput & Lankheet, 1987; Imamura et al, 1992; Yu et al, 1993; Ogawa, 1998; Nagayama et al, 2004; Rinberg et al, 2006). These studies are subject to a variety of methodological problems, including: uncertainty of the identity of the cell as a mitral cell; effects of anesthesia; bias in selecting/isolating cells; and short lengths of recording.…”

Mechanisms and Function of Dendritic Exocytosis

“…In fact, most granule cells do not appear to have an axon at all, but instead consisted of “protoplasmic elongations” that span several adjacent regions of dense neuropil in close contact with dendrites of mitral cells (Cajal, 1911; Golgi, 1875; Woolf et al, 1991b). It was not until the advent of electron microscopy and intracellular recording techniques that it was appreciated that granule cells, even without an axon, contain structures resembling synaptic vesicles and that they could exert a robust, long lasting inhibitory effect on contacting mitral cells upon depolarization (Green et al, 1962; Jahr and Nicoll, 1980; Phillips et al, 1963; Price and Powell, 1970a, b). …”

An intracellular study of dendrodendritic inhibitory synapses on mitral cells in the rabbit olfactory bulb.

“…produces a prolonged inhibition of mitral cell activity in the rabbit olfactory bulb (Green, Mancia & Baumgarten, 1962;Ochi, 1963;Phillips, Powell & Shepherd, 1963;Nicoll, 1969). Long lasting i.p.s.p.s have been demonstrated with intracellular recordings from mitral cells (Yamamoto, Yamamoto & Iwama, 1963;Phillips et al 1963;Nicoll, 1969;Reese & Shepherd, 1972).…”

“…Long lasting i.p.s.p.s have been demonstrated with intracellular recordings from mitral cells (Yamamoto, Yamamoto & Iwama, 1963;Phillips et al 1963;Nicoll, 1969;Reese & Shepherd, 1972). Green et al (1962) suggested that the axon collaterals of mitral cells had a direct inhibitory effect on the mitral cells. However, later physiological studies strongly supported the idea that an inhibitory interneurone, most probably a granule cell, is interpolated in the inhibitory pathway onto the mitral cell (Yamamoto et al 1963;Phillips et al 1963;Shepherd, 1963;Nicoll, 1969).…”