Recurrent Intracranial Neurenteric Cysts

Chaynes, Patrick; Bousquet, P.; Sol, Jean Christophe; Mj, Delisle; Richaud, J; Lagarrigue, J

doi:10.1007/s007010050192

Cited by 35 publications

(42 citation statements)

References 24 publications

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“…1,17) Therefore, their epithelium is positive for cytokeratin, carcinoembryonic antigen, and EMA, but negative for GFAP and S-100 protein on immunohistochemical analysis. 1,18) Although most neurenteric cysts are histologically benign, 1,18,19) Perrini et al reported that one-third of cases treated by partial or subtotal resection later experience symptomatic recurrence. 6) On the other hand, pathological proof of malignant transformation in the surgical specimen is extremely rare.…”

Section: Discussionmentioning

confidence: 99%

“…Conventional radiotherapy and chemotherapy have shown little effect on histologically benign neurenteric cysts. 1,18) As shown in Table 1, among previously reported cases, two patients underwent radiation therapy and one died 1 year later and the other was not followed-up over the long term. 13,14) Sahara et al reported a case of a neurenteric cyst in the foramen magnum with malignant transformation.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Malignant Transformation of a Neurenteric Cyst in the Posterior Fossa Presenting with Intracranial Metastasis: A Case Report and Literature Review

Fujisawa

Oya

Higashi

et al. 2015

NMC Case Report Journal

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Malignant Transformation of a Neurenteric Cyst in the Posterior Fossa Presenting with Intracranial Metastasis: A Case Report and Literature Review

Fujisawa

Oya

Higashi

et al. 2015

NMC Case Report Journal

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“…Recurrence has been reported as occurring between 4 months and 14 years postoperatively, and has occurred even after macroscopic gross-total resection. 4,31 It is difficult to predict if and when these cysts will recur, given their rarity and the lack of sufficient reports and follow-up data. In our case, at 1-year follow-up, the patient remained neurologically intact without radiographic evidence of cyst recurrence or minor residual disease.…”

Section: Discussionmentioning

confidence: 99%

Staged bilateral far-lateral approach for bilateral cervicomedullary junction neurenteric cysts in a 10-year-old girl

Patel

Liu²

2013

PED

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Neurenteric cysts are rare and benign lesions that consist of ectopic alimentary tissue residing in the central nervous system. They tend to occur most frequently in an intraspinal rather than intracranial location. Intracranial neurenteric cysts are a rare occurrence in the pediatric population. These lesions typically present as unilateral cystic structures in the lower cerebellopontine angle and craniocervical junction. To the authors' knowledge, there have been no reported cases of bilateral localization of intracranial neurenteric cysts. In this report, they present an unusual case of a 10-year-old girl who was found to have bilateral intracranial neurenteric cysts at the pontomedullary junction. The patient was successfully treated with staged, bilateral far-lateral transcondylar resection of the cysts. The authors also provide a brief overview of the literature describing intracranial neurenteric cysts in children.

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“…A total surgical resection of the lesion is the most effective therapeutic method, as the residual cyst walls, particularly walls that are large enough to overlap, may cause recurrence (1,6,8). Although recurrence and dissemination are not uncommon in NCs (19)(20)(21), the malignant transformation of NC is extremely rare. Hamlat et al (22) and Bejjani et al (23) defined the criteria for the malignant transformation of intracranial epidermoid and dermoid cysts; however, no strict criteria for the malignant transformation of NCs have been previously developed.…”

Section: Discussionmentioning

confidence: 99%

Recurrent intracranial neurenteric cyst with malignant transformation: A case report and literature review

Yang

Fang

et al. 2016

Oncology Letters

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Abstract. Neurenteric cysts (NCs) are uncommon congenital cystic lesions. Malignantly transformed NCs are extremely rare. The present study reports the case of a recurrent foramen magnum NC with a malignant transformation and reviews 8 previously reported cases. A 58-year-old woman with a 5-month history of occasional headaches, dizziness and vomiting presented to the Beijing Tiantan Hospital (Beijing, China) with palsy of the left cranial IX and X nerves, decreased sensation in the limbs on the right side and an ataxic gait. Magnetic resonance imaging (MRI) scans revealed a cystic mass in the left side of the foramen magnum, positioned anteriolaterally to the medulla oblongata. Surgery using a left suboccipital retrosigmoid approach was performed. The lesion was partially resected and was histopathologically diagnosed as an NC with focal hyperplasia of the epithelial cells. Additional MRI scans that were performed 25 months later revealed a solid lesion posterior to the medullar oblongata. Therefore, surgery using a suboccipital midline approach was performed. The solid lesion was sub-totally removed and was histopathologically diagnosed as a well-differentiated papillary adenocarcinoma. At 1 month post-surgery, the patient's condition worsened, eventually resulting in mortality due to respiratory failure. Based on the findings of the present case and previous literature, strict criteria for malignant-transformed NCs were created. The location distribution of malignant-transformed NCs does not coincide with the location distribution of all NCs, and malignantly transformed NCs usually occur in adult patients and present as atypical radiological features. Surgery is the optimal treatment for malignantly transformed NCs, and the effectiveness of adjuvant therapy requires additional studies.

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Recurrent Intracranial Neurenteric Cysts

Cited by 35 publications

References 24 publications

Malignant Transformation of a Neurenteric Cyst in the Posterior Fossa Presenting with Intracranial Metastasis: A Case Report and Literature Review

Malignant Transformation of a Neurenteric Cyst in the Posterior Fossa Presenting with Intracranial Metastasis: A Case Report and Literature Review

Staged bilateral far-lateral approach for bilateral cervicomedullary junction neurenteric cysts in a 10-year-old girl

Recurrent intracranial neurenteric cyst with malignant transformation: A case report and literature review

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