Recurrent juvenile granulosa cell tumor of the ovary managed by palliative radiotherapy

Abstract

Prognosis in the few patients with advanced-stage juvenile granulosa cell tumor (JGCT) of the ovary has traditionally been unfavorable. We report a recurrent JGCT patient managed by palliative radiotherapy. A 37-year-old woman with recurrent JGCT received a combination of paclitaxel-carboplatin chemotherapy and then single-agent docetaxel, but her disease progressed with multiple abdominal masses and ascites. We chose palliative radiation therapy to relieve her complaints. Whole-abdominal external beam radiotherapy with pelvic boost was delivered. She tolerated the treatment well. After the completion of radiotherapy, ultrasonography showed shrinkage of the tumor, and the ascites disappeared. We should consider using radiation therapy in a palliative setting for such patients with recurrent JGCT suffering from abdominal complaints.

Investigating differentiation mechanisms of the constituent cells of sex cord-stromal tumours of the ovary

“…Sertoli-Leydig cell tumours constitute only 1% of ovarian sex-cord stromal tumours and less than 0.5% of all primary ovarian tumours [9]. Finally, granulosa cell tumours account for approximately 5% of all ovarian tumours [7].…”

Juvenile granulosa cell ovarian tumor: clinicopathological evaluation of ten patients

“…For residual or recurrent adult type granulosa cell tumors, radiotherapy is recommended (13). Hirakawa et al (12) did not obtain any response with chemotherapy in a patient with recurrent JGCOT who had multiple abdominal masses. They observed a regression in the size of the tumors and clearance of the ascites with whole abdominal external beam radiotherapy.…”

“…Surgical and adjuvant treatments in advanced stage or recurrent diseases are unclear. The combination of taxane and platinum can be an alternative treatment option (12). For residual or recurrent adult type granulosa cell tumors, radiotherapy is recommended (13).…”

Juvenile Granulosa Cell Ovarian Tumor: A Case Report and Review of Literature

“…Since JGCTs occur predominantly in prepubertal girls, and most of them 23 Fortunately, the overall prognosis for JGCTs is excellent, with reports of survival as high as 97% during an average follow-up period of 3.5 years. 4 However, tumor recurrence at 48 months after initial conservative surgery for JGCT has been reported.…”