Recurrent major depressive disorder's impact on end-of-life care of cancer: A nationwide study

Fond, Guillaume; Baumstarck, Karine; Auquier, Pascal; Fernandes, Sara; Pauly, Vanessa; Bernard, Cécile Isabelle; Orléans, Veronica; Llorca, Pierre‐Michel; Lançon, Christophe; Salas, Sébastien; Boyer, Laurent

doi:10.1016/j.jad.2019.12.003

Cited by 10 publications

(6 citation statements)

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“…The present investigation found that both anxiety and depression were associated with a greater likelihood of receiving a palliative encounter. Some studies have found depression to be associated with receipt of palliative 15 and hospice 16,17 services. Our findings reinforce these and further show that anxiety is associated with palliative utilization.…”

Section: Discussionmentioning

confidence: 99%

“…Findings specific to self‐reported elevated anxiety are limited but indicate higher odds of receiving anticancer therapy in the 2 weeks before death 13,14 . Depression diagnoses and elevated self‐reported symptomology are often associated with a greater likelihood of receiving anticancer therapy and having an ICU visit in the 2–4 weeks before death but also a greater likelihood of receiving palliative and hospice care 13–17 . There are inconsistencies among these depression‐related findings with some results showing an opposite pattern of effects 15–17 .…”

Section: Introductionmentioning

confidence: 99%

“…Depression diagnoses and elevated self‐reported symptomology are often associated with a greater likelihood of receiving anticancer therapy and having an ICU visit in the 2–4 weeks before death but also a greater likelihood of receiving palliative and hospice care 13–17 . There are inconsistencies among these depression‐related findings with some results showing an opposite pattern of effects 15–17 . Further, many studies have involved relatively homogenous samples consisting of 80%–100% White participants, 6,13,14,16,17 highlighting the need for additional work in this area.…”

Section: Introductionmentioning

confidence: 99%

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Anxiety, depression, and end‐of‐life care utilization in adults with metastatic cancer

et al. 2021

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Objective End‐of‐life care for patients with cancer is often overly burdensome, and palliative and hospice care are underutilized. The objective of this study was to evaluate whether the mental health diagnoses of anxiety and depression were associated with variation in end‐of‐life care in metastatic cancer. Methods This study used electronic health data from 1,333 adults with metastatic cancer who received care at two academic health centers in Louisiana, USA, and died between 1/1/2011–12/31/2017. The study used descriptive statistics to characterize the sample and logistic regression to examine whether anxiety and depression diagnoses in the six months before death were associated with utilization outcomes (chemotherapy, intensive care unit [ICU] visits, emergency department visits, mechanical ventilation, inpatient hospitalization, palliative care encounters, and hospice utilization), while controlling for key demographic and health covariates. Results Patients (56.1% male; 65.6% White, 31.1% Black) commonly experienced depression (23.9%) and anxiety (27.2%) disorders within six months of death. Anxiety was associated with an increased likelihood of chemotherapy (odds ratio [OR] = 1.42, p = 0.016), ICU visits (OR = 1.40, p = 0.013), and inpatient hospitalizations (OR = 1.85, p < 0.001) in the 30 days before death. Anxiety (OR = 1.95, p < 0.001) and depression (OR = 1.34, p = 0.038) were associated with a greater likelihood of a palliative encounter. Conclusions Patients with metastatic cancer who had an anxiety disorder were more likely to have burdensome end‐of‐life care, including chemotherapy, ICU visits, and inpatient hospitalizations in the 30 days before death. Depression and anxiety both increased the odds of palliative encounters. These results emphasize the importance of mental health considerations in end‐of‐life care.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anxiety, depression, and end‐of‐life care utilization in adults with metastatic cancer

et al. 2021

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“…This increased mortality may be explained by different care of cancer at every stage including screening, care and end-of-life (EOL)/terminal cancer. Previously, we have found that men and women with SPD died younger from their terminal cancer compared to non-SPD (by 8 years for schizophrenia 4 , 5 years for bipolar disorders 5 and 3 years for recurrent major depressive disorder 6 ). Women with SPD have a loss of chance of being screened for breast cancer 7 .…”

Section: Introductionmentioning

confidence: 90%

End of life breast cancer care in women with severe mental illnesses

Fond

Pauly

Duba

et al. 2021

Sci Rep

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Little is known on the end-of-life (EOL) care of terminal breast cancer in women with severe psychiatric disorder (SPD). The objective was to determine if women with SPD and terminal breast cancer received the same palliative and high-intensity care during their end-of-life than women without SPD. Study design, setting, participants. This population-based cohort study included all women aged 15 and older who died from breast cancer in hospitals in France (2014–2018). Key measurements/outcomes. Indicators of palliative care and high-intensity EOL care. Multivariable models were performed, adjusted for age at death, year of death, social deprivation, duration between cancer diagnosis and death, metastases, comorbidity, smoking addiction and hospital category. The analysis included 1742 women with SPD (287 with bipolar disorder, 1075 with major depression and 380 with schizophrenia) and 36,870 women without SPD. In multivariate analyses, women with SPD had more palliative care (adjusted odd ratio aOR 1.320, 95%CI [1.153–1.511], p < 0.001), longer palliative care follow-up before death (adjusted beta = 1.456, 95%CI (1.357–1.555), p < 0.001), less chemotherapy, surgery, imaging/endoscopy, and admission in emergency department and intensive care unit. Among women with SPD, women with bipolar disorders and schizophrenia died 5 years younger than those with recurrent major depression. The survival time was also shortened in women with schizophrenia. Despite more palliative care and less high-intensity care in women with SPD, our findings also suggest the existence of health disparities in women with bipolar disorders and schizophrenia compared to women with recurrent major depression and without SPD. Targeted interventions may be needed for women with bipolar disorders and schizophrenia to prevent these health disparities.

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“…1,2 The current care organization is not adequate to address mental disorders (eg, schizophrenia, bipolar disorder and major depression) that emerge as a major health disparity category. [2][3][4][5][6] Patients with mental disorders have a marked decrease in life expectancy (eg, approximately 14 years on average for patients with schizophrenia). 7 They are confronted with persistent gaps in access to and receipt of mental health care.…”

Section: Introductionmentioning

confidence: 99%

<p>Measuring the Patient Experience of Mental Health Care: A Systematic and Critical Review of Patient-Reported Experience Measures</p>

Fernandes¹,

Fond²,

Zendjidjian³

et al. 2020

PPA

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Background There is growing concern about measuring patient experience with mental health care. There are currently numerous patient-reported experience measures (PREMs) available for mental health care, but there is little guidance for selecting the most suitable instruments. The objective of this systematic review was to provide an overview of the psychometric properties and the content of available PREMs. Methods A comprehensive review following the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines was conducted using the MEDLINE database with no date restrictions. The content of PREMs was analyzed using an inductive qualitative approach, and the methodological quality was assessed according to Pesudovs quality criteria. Results A total of 86 articles examining 75 PREMs and totaling 1932 items were included. Only four PREMs used statistical methods from item response theory (IRT). The 1932 items covered seven key mental health care domains: interpersonal relationships (22.6%), followed by respect and dignity (19.3%), access and care coordination (14.9%), drug therapy (14.1%), information (9.6%), psychological care (6.8%) and care environment (6.1%). Additionally, a few items focused on patient satisfaction (6.7%) rather than patient experience. No instrument covered the latent trait continuum of patient experience, as defined by the inductive qualitative approach, and the psychometric properties of the instruments were heterogeneous. Conclusion This work is a critical step in the creation of an item library to measure mental health care patient-reported experience that will be used in France to develop, validate, and standardize item banks and computerized adaptive testing (CAT) based on IRT. It will also provide internationally replicable measures that will allow direct comparisons of mental health care systems. Trial Registration NCT02491866.

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Recurrent major depressive disorder's impact on end-of-life care of cancer: A nationwide study

Cited by 10 publications

References 35 publications

Anxiety, depression, and end‐of‐life care utilization in adults with metastatic cancer

Anxiety, depression, and end‐of‐life care utilization in adults with metastatic cancer

End of life breast cancer care in women with severe mental illnesses

<p>Measuring the Patient Experience of Mental Health Care: A Systematic and Critical Review of Patient-Reported Experience Measures</p>

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