Recurrent metastatic hepatocellular carcinoma presenting as consecutive “mirror image” intracerebral haematomas

Cho, Dong-Charn; Yi, Hyeong-Joong; Ko, Yong; Oh, Sea Cheon; Lee, Seung-Ro; Paik, Sun-Sook

doi:10.1016/j.jocn.2004.08.026

Cited by 10 publications

(9 citation statements)

References 8 publications

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“…One of the noticeable features is that brain metastasis from HCC had a tendency of bleeding as in the previous reports 1,2,4,9,10,13,14,16,18,21) , though no patients were classified as Child-Pugh grade C, and had a delayed prothrombin time in this study. Thus, 70.0% of the patients had stroke-like presentation due to tumor bleeding, and over 90% of the lesions had the hemorrhagic components in or near the mass on MR images and/or CT scan.…”

Section: Clinical and Radiological Featuressupporting

confidence: 48%

Little Response of Cerebral Metastasis from Hepatocellular Carcinoma to Any Treatments

Han

Kim

Park

et al. 2010

J Korean Neurosurg Soc

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Objective :We retrospectively evaluated the survival outcome of patients with brain metastasis from hepatocellular carcinoma (HCC). Methods : Between 1991 and 2007, a total of 20 patients were diagnosed as having brain metastasis from HCC. The mean age of the patients was 55 ± 13 years, and 17 (85.0%) were men. Seventeen (85.0%) patients had already extracranial metastases. The median time from diagnosis of HCC to brain metastasis was 18.5 months. Fourteen (70.0%) patients had stroke-like presentation due to intracerebral hemorrhage (ICH). Ten (50.0%) patients had single or solitary brain metastasis. Among a total of 34 brain lesions, 31 (91.2%) lesions had the hemorrhagic components. Results : The median survival time was 8 weeks (95% CI, 5.08-10.92), and the actuarial survival rates were 85.0%, 45.0%, 22.5%, and 8.4% at 4, 12, 24, and 54 weeks. Age < 60 years, treatment of the primary and/or extracranial lesions, and recurrent ICH were the possible prognostic factors (p = 0.044, p < 0.001, and p = 0.111, respectively). The median progression-free survival (PFS) time was 3 months (95% CI, 0.95-5.05). Conclusion :The overall survival of the patients with brain metastasis from HCC was very poor with median survival time being only 8 weeks. However, the younger patients less than 60 years and/or no extracranial metastases seem to be a positive prognostic factor. 10.3340/jkns.2010.47.5.325 KEY WORDS : Brain metastasis˙ Hepatocellular carcinoma˙ Survival outcome˙ Prognostic factor.

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Section: Clinical and Radiological Featuressupporting

confidence: 48%

Little Response of Cerebral Metastasis from Hepatocellular Carcinoma to Any Treatments

Han

Kim

Park

et al. 2010

J Korean Neurosurg Soc

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“…Estimations suggest mortality rates of 250,000-500,000 per year worldwide [65,66]. Most patients die within several months following initial diagnosis [67]. It is the fifth most common cancer in the world [66,68] and is mostly prevalent in Africa and East Asia.…”

Section: Hepatocellular Carcinomamentioning

confidence: 99%

“…In these regions, it constitutes one of the most frequent malignancies due to the high prevalence of hepatitis B and C. Men are 4.8 times more likely to be affected than women [57,66,69,70]. Information regarding BM from HCC is based on case reports [65,67,68,[71][72][73][74][75][76][77] and Case report with no patient series c One patient's therapy was not specified small case studies [57,66,[69][70][71]78]. The Japanese tumor register estimates that 1.2% of all BM originate from HCC [57,74].…”

Section: Hepatocellular Carcinomamentioning

confidence: 99%

“…Bleeding from HCC BM is quite common and is reported to be as high as 87.5% [67,69,70,72,74,75,79]. This may be explained by tumor hypervascularity and chronic liver dysfunction with abnormal blood (5) Lung (8) Bone (10) Liver (7) None (4) Supra (14) Infra (3) Both (5) (3) Liver (2) Bone (1) Supra (4) --4/2.9 ---…”

Section: Management and Therapymentioning

confidence: 99%

“…Most authors suggest combined surgical resection of these BM with WBRT, which improves both survival and patient quality of life [67,69,71,75]. Kim et al [70] state that WBRT alone was not effective and does not improve patient survival.…”

Section: Management and Therapymentioning

confidence: 99%

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Modern management of rare brain metastases in adults

et al. 2011

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Brain metastases (BM) represent the main cause of intracranial neoplasms in adults, while being relatively less common in children. Today, better treatment options of the primary malignancy lead to higher remission rates as well as prolonged stable clinical conditions. This may in part explain the increased incidence of BM. Morbidity and mortality rates in patients with malignancies deteriorate significantly in cases of metastatic involvement of the central nervous system. Nowadays, especially modern management using surgical, medical, and radiotherapeutic options for treatment of BM tends to improve survival rates and enhance quality of life. Nonetheless, almost all treatment options are considered as palliative. In this review, we outline current knowledge of the incidence, diagnostic facilities, and therapeutic management of rare BM, with consideration of the basic aspects of the primary malignancy.

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A case of monocular blindness as the initial presentation of hepatocellular carcinoma with skull metastasis

Ito

Saito

Iwaba

et al. 2011

Clin J Gastroenterol

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A 52-year-old man suffering from monocular blindness, with light perception only, was admitted to our hospital. The symptom had begun as low vision and developed rapidly within 3 weeks into monocular blindness in the right eye, with no other systemic manifestations. Imaging examinations revealed multiple hepatocellular carcinomas in the cirrhotic liver, and tumors at the skull base and vertebra. A pathological and immunochemical study of specimens obtained by endoscopic transnasal tumor biopsy and laminectomy revealed them to be metastatic hepatocellular carcinomas (HCCs). Although the patient underwent radiation therapy and chemotherapy, he died 5 months after admission to our hospital. The cranial HCC, involving only the optic canal, may have disturbed the optic nerve in preference to the other cranial nerves. This is the first report of a HCC patient with monocular blindness as the initial presentation of the disease.

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Recurrent metastatic hepatocellular carcinoma presenting as consecutive “mirror image” intracerebral haematomas

Cited by 10 publications

References 8 publications

Little Response of Cerebral Metastasis from Hepatocellular Carcinoma to Any Treatments

Little Response of Cerebral Metastasis from Hepatocellular Carcinoma to Any Treatments

Modern management of rare brain metastases in adults

A case of monocular blindness as the initial presentation of hepatocellular carcinoma with skull metastasis

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