Modern management of rare brain metastases in adults

Abstract

Brain metastases (BM) represent the main cause of intracranial neoplasms in adults, while being relatively less common in children. Today, better treatment options of the primary malignancy lead to higher remission rates as well as prolonged stable clinical conditions. This may in part explain the increased incidence of BM. Morbidity and mortality rates in patients with malignancies deteriorate significantly in cases of metastatic involvement of the central nervous system. Nowadays, especially modern management using surgical, medical, and radiotherapeutic options for treatment of BM tends to improve survival rates and enhance quality of life. Nonetheless, almost all treatment options are considered as palliative. In this review, we outline current knowledge of the incidence, diagnostic facilities, and therapeutic management of rare BM, with consideration of the basic aspects of the primary malignancy.

Neuroimaging and clinical characteristics of brain metastases from esophageal carcinoma in Chinese patients

“…In the present study, peripherally enhanced thin cyst walls (37/62, 59.7%) were more frequently observed compared to other common metastatic brain tumors. In Table 4, imaging features of brain metastases associated with esophageal carcinomas that have been published since 2004 [2,[11][12][13][14][15][16][17][18][19] are presented. In particular, cystic, enhanced tumors with minimal edema were notable.…”

“…[5][6][7][8]11,16] However, the majority of esophageal carcinoma reports were still based on autopsies. [9,10] With the clinical application of MRI, a larger number of reports of esophageal carcinoma have been published, [2][3][4][12][13][14][15][17][18][19] although, few reports have described both MRI findings and clinical features. Worldwide, the incidence of brain metastases from esophageal carcinoma ranges from 0.3% to 13%.…”

Surgical Treatment of Eloquent Area Metastatic Brain Lesions from Unusual Primaries: Early Outcome

“…It is still an evolving area of cancer care. Very few studies have further reported about treatment of rare brain metastases [15]. Our study focuses on surgical treatment of eloquent region metastases arising from unusual primary malignancies.…”

“…There is paucity of literature regarding management of eloquent area metastases arising from rare primary malignancies [15]. We present our experience after surgery for 10 consecutive patients harbouring eloquent area metastasis from rare primary malignancies to illustrate the safety and effectiveness of microsurgical resection leading to good early outcome.…”