Recurrent molar pregnancies in a family with extensive intermarriage: Report of a family and review of the literature

Abstract

In families with extensive intermarriage and recurrent molar pregnancies, patients and their spouses may have unusual human lymphocytic antigen histocompatibility, which supports the possibility of a strong genetic predisposition expressed at the level of major histocompatibility class I and II gene translation.

Mole maker phenotype: possible narrowing of the candidate region

“…A careful revision of the families reported [6][7][8][9][10][11][12] suggests an autosomal recessive genotype of women experiencing recurrent familial molar pregnancies, as proposed by Helwani et al 12 Only one family has Candidate region for mole maker phenotype y been studied by molecular methods so far. 1 In this family the recurrent molar pregnancies demonstrated a biparental diploid chromosomal constitution.…”

“…[3][4][5] Familial HM (MIM 231090) is exceedingly rare, with only seven families having been reported so far. [6][7][8][9][10][11] Consanguinity was often noted between the partners, suggesting an autosomal recessive etiology in the conceptus genotype. 10 Recently Helwani et al 12 reported a family in which consanguinity was also noted between the parents of the women.…”

“…[6][7][8][9][10][11] Consanguinity was often noted between the partners, suggesting an autosomal recessive etiology in the conceptus genotype. 10 Recently Helwani et al 12 reported a family in which consanguinity was also noted between the parents of the women. This finding together with biparentality of the moles in this family prompted that group to consider an autosomal recessive genotype in the woman.…”

Recurrent familial hydatidiform mole - a rare clinical problem

“…Our patient also was a Muslim. Seoud et al (10) reported familial recurrent moles in a family with extensive intermarriage. Molar tissue should be genotyped with polymorphic DNA markers to determine the parental origin as this helps to plan therapeutic options.…”

A familial case of recurrent hydatidiform molar pregnancies with biparental genomic contribution

“…Recently, we reported a new familial case of recurrent HMs occurring in three members (two sisters and their cousin) of a Lebanese family (Seoud et al 1995). Histological analysis of several molar tissues from the two sisters revealed general trophoblastic hyperplasia and the absence of fetal tissues.…”