Recurrent pemphigus vulgaris limited to the surgical area after mastectomy

Shirahama, Shigeho; Furukawa, Fukumi; Takigawa, Masaharu

doi:10.1016/s0190-9622(98)70388-3

Cited by 11 publications

(7 citation statements)

References 48 publications

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“…Cutaneous insults that disturb the dermal‐epidermal junction may uncover epidermal antigens, leading to activation of antibodies and clinical disease. In addition, genetic factors may predispose patients to produce pathogenic antibodies after nonspecific epidermal damage 32 . Another intriguing possibility relevant to our case is the production of antibodies against altered epithelial adhesion molecule expression on squamous cell carcinoma 33–36 .…”

Section: Discussionmentioning

confidence: 87%

“…In addition, genetic factors may predispose patients to produce pathogenic antibodies after nonspecific epidermal damage. 32 Another intriguing possibility rele-vant to our case is the production of antibodies against altered epithelial adhesion molecule expression on squamous cell carcinoma. [33][34][35][36] Inaoki and colleagues identified desmoglein-1 expression on the surface of a metastatic vulvar squamous cell carcinoma in a patient who developed generalized pemphigus foliaceus.…”

Section: Discussionmentioning

confidence: 98%

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Pemphigus Foliaceus Masquerading as Postoperative Wound Infection: Report of a Case and Review of the Koebner and Related Phenomenon following Surgical Procedures

Rotunda

BHUPATHY

Dye

et al. 2006

Dermatologic Surgery

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 98%

Pemphigus Foliaceus Masquerading as Postoperative Wound Infection: Report of a Case and Review of the Koebner and Related Phenomenon following Surgical Procedures

Rotunda

BHUPATHY

Dye

et al. 2006

Dermatologic Surgery

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“…The lack of a high frequency of mucosal disease may be one of the clinical features in this subgroup of patients with dual diagnosis. There are studies in the literature in which patients with PV have disease limited to the skin [29]. …”

Section: Discussionmentioning

confidence: 99%

Dual Diagnosis of Pemphigus and Pemphigoid

Sami

Ahmed²

2001

Dermatology

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Background: Pemphigus and pemphigoid are two distinct groups of autoimmune blistering diseases. There are many reports of the simultaneous presence of clinical and serological features of both diseases in the same patient. Objective: This study is a retrospective review of the present literature on reports of patients with features of both pemphigus and pemphigoid. We recommend that these patients be considered as having a dual diagnosis. Methods: A review of the English language, peer-reviewed literature was conducted on patients described with features of pemphigus and pemphigoid. Available data on clinical profile, histology, immunopathology, treatment, follow-up and outcome were studied in 30 patients. They were divided into three groups: (1) bullous pemphigoid and pemphigus vulgaris, (2) mucous membrane or cicatricial pemphigoid and pemphigus vulgaris and (3) bullous pemphigoid and pemphigus foliaceus. Results: In all three groups, most patients had a clinical phenotype resembling both diseases. In 17 patients with bullous pemphigoid and pemphigus vulgaris, 83% had a skin biopsy consistent with bullous pemphigoid, 70% had direct immunofluorescence studies typical of bullous pemphigoid and sera of 83% had antibodies typical of pemphigus vulgaris on indirect immunofluorescence. In 10 patients with mucous membrane or cicatricial pemphigoid and pemphigus vulgaris, a histology of mucous membrane pemphigoid was reported in 60% of the patients, direct immunofluorescence studies typical of mucous membrane pemphigoid were reported in 70% of the patients and in 80%, autoantibodies characteristic of pemphigus vulgaris were observed. In 3 patients with bullous pemphigoid and pemphigus foliaceus, the histologies were consistent with bullous pemphigoid, direct immunofluorescence was typical of pemphigus foliaceus and their sera had both autoantibodies. The majority of the 30 patients required long-term high-dose corticosteroids and immunosuppressive agents to control their disease. Three patients with bullous pemphigoid and pemphigus vulgaris (18%) died due to effects of prolonged immunosuppression. Conclusion: We characterize a group of patients who have clinical, histological and immunopathological features of bullous or mucous membrane or cicatricial pemphigoid with serological features of pemphigus. These patients did not achieve a prolonged clinical remission by conventional therapy. It is possible that early identification of these patients may improve their prognosis.

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“…There are numerous case reports on ABD and breast cancer including predominantly BP [20,[81][82][83][84][85] and PV [86,87] with well-documented BP-lesion induction with radiotherapy.…”

Section: Malignancies Associated With Abdmentioning

confidence: 99%