Recurrent polyserositis (familial mediterranean fever; Periodic disease)

Ehrenfeld, E. N.; Eliakim, M; Rachmilewitz, M.

doi:10.1016/0002-9343(61)90227-3

Cited by 78 publications

(30 citation statements)

References 21 publications

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“…Regarding the first factor, previous studies have shown that recurrent attacks of FMF caused peritoneal fibrosis leading to scarring of the salpinx, thereby leading to mechanical (secondary) infertility (10). Similarly, early studies showed a higher rate of abortion among patients with FMF compared with healthy women (11).…”

Section: Discussionmentioning

confidence: 99%

Pregnancy outcomes in women with Familial Mediterranean Fever receiving colchicine: Is amniocentesis justified?

Ben‐Chetrit¹,

Ben-Chetrit²,

Berkun³

et al. 2010

Arthritis Care & Research

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Objective. To evaluate the outcome of pregnancies in women with familial Mediterranean fever (FMF) who are taking colchicine, and to reconsider the justification for amniocentesis in these women. Methods. The outcome of 179 pregnancies in a group of women with FMF taking colchicine was compared with the outcome of 197 pregnancies in women with FMF who did not take colchicine during pregnancy and with 312 pregnancies in another cohort of healthy pregnant women of similar age and ethnicity.Results. There was no difference in the 3 groups regarding early abortions, late abortions, or congenital malformations. There was a mild trend towards a better outcome for the colchicine-treated group but these results did not reach statistical significance. Conclusion. Treatment with colchicine during pregnancy in patients with FMF is beneficial in controlling the disease while not affecting the outcome of the pregnancy; therefore there is no justification for recommending amniocentesis in women taking colchicine solely because of this treatment.

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Section: Discussionmentioning

confidence: 99%

Pregnancy outcomes in women with Familial Mediterranean Fever receiving colchicine: Is amniocentesis justified?

Ben‐Chetrit¹,

Ben-Chetrit²,

Berkun³

et al. 2010

Arthritis Care & Research

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“…[6][7][8][9][10][11] ; the patients described were predominantly of Jewish origin and lived in the USA. .Recent large series have involved Jewish residents of Israel [12][13][14], Turks [15], Armenians (in the USA) [16,17], and Arabs [18]; in the latter report (from Kuwait), those studied came from Palestine (N = 112), Egypt (N = 26), Lebanon (N = 17), Syria (N = 13) and Iraq (N = 7), most being "fair-skinned" Arabs. It seems to be unusual in Iran.…”

Section: Accepted For Publication 28 November 1990mentioning

confidence: 99%

“…Other manifestations are nodular rashes, Schonlein-Henoch purpura [5,46,47], urticaria [6,47], bullous lesions [48], and a vasculitis which is usually associated with an immune-complex nephropathy [49]. In addition, splenomegaly is present in about 30% of cases overall [11][12][13] and, like the arthropathy and dermatological lesions, is less frequent in Arab patients [18]. Table 4 summarizes some less common clinical features.…”

Section: Clinical Aspectsmentioning

confidence: 99%

“…Severe headaches Pharyngitis [50] Pericarditis [51] Myocarditis Myalgia [16,52] Panniculitis [53] Ophthalmic Problems: colloid bodies [13], episcleritis [54] Acute orchitis [55] -infertility Mollaret's meningitis [61,62] Childhood growth retardation [7,9].…”

Section: Table 4 Some Less Common Clinical Features Of Rhpmentioning

confidence: 99%

“…The most important complication of this disease is amyloid AA (derived from serum AA) deposition in many tissues (including spleen, lung, heart, liver, and intestine), but most importantly the renal glomerulae [12][13][14]. This was first demonstrated by Mamou in 1952 [68,69].…”

Section: Complications Of Rhpmentioning

confidence: 99%

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Recurrent Hereditary Polyserositis or Familial Mediterranean Fever: An Overview

Cook

1991

Ann Saudi Med

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The etiology and pathogenesis of recurrent hereditary polyserositis (RHP) remain undetermined. There is good evidence for a genetic basis (transmission being by a recessive Mendelian mode of inheritance), but not all cases have a family history and an infective (or other environmental) component has not been excluded. The marked variation in presentation and complications (in particular the prevalence of amyloid deposition) in different series suggests that this might not be a homogeneous entity. Vascular involvement is a basic prerequisite for the periodic attacks, and evidence for transient immunological abnormalities is incontrovertible. There are no reliable diagnostic techniques. Colchicine is of value in treatment, but its mode of action is unclear. More macro-and microepidemiological studies are required and will be of paramount importance. Clinical observations and molecular genetic studies should address the possibility that two or more immunological or metabolic defects might be interwoven; why for example do only some affected groups develop AA amyloidosis? Simple, non-invasive diagnostic tests are required for the uncomplicated disease and also for the presence of amyloid deposition. Preventive strategies might eventually involve genetic engineering techniques, but in the immediate future, education of doctors and other health care workers-to raise the "index of awareness" of RHP, in order that colchicine treatment can be commenced early in the disease-forms an important strategy. Colchicine therapy is not without complications and an alternative chemotherapeutic agent should be sought. GC Cook, Recurrent Hereditary Polyserositis or Familial Mediterranean Fever: An Overview. 1991; 11(5): 576-584 Many aspects of recurrent hereditary polyserositis (RHP) have recently been reviewed [1][2][3][4]. The first description of a familial condition comprising "recurring attacks of a peculiar nature" was made by Janeway and Mosenthal in 1908. In that report, a 16-year-old Jewish schoolgirl "without special neurotic inheritance" had suffered febrile bouts associated with abdominal pain, which consistedof prodromal, crescendo, and recovery phases, since the age of 2 weeks [5]. In view of the dramatic nature of many attacks, it is perhaps surprising that no records of the disease have been discovered in early medical (and also lay) literature from the Mediterranean and Middle East, including the work of Hippocrates, the Bible, and the Quran. Subsequent accounts of RHP followed

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