Recurrent potential pulse technique for improvement of glucose sensing ability of 3D polypyrrole

Abstract

In this work, a new approach for using a 3D polypyrrole (PPy) conducting polymer as a sensing material for glucose detection is proposed. Polypyrrole is electrochemically polymerized on a platinum screen-printed electrode in an aqueous solution of lithium perchlorate and pyrrole. PPy exhibits a high electroactive surface area and high electrochemical stability, which results in it having excellent electrocatalytic properties. The studies show that using the recurrent potential pulse technique results in an increase in PPy sensing stability, compared to the amperometric approach. This is due to the fact that the technique, under certain parameters, allows the PPy redox properties to be fully utilized, whilst preventing its anodic degradation. Because of this, the 3D PPy presented here has become a very good candidate as a sensing material for glucose detection, and can work without any additional dopants, mediators or enzymes.

3D Scaffolds Based on Conductive Polymers for Biomedical Applications

“…The authors obtained non-porous structures with PPy particles with sizes up to the milimiter scale by controlling the deposition charge of the method. 89 Another example is the piezoresistant pressure sensor developed by Ding et al to monitor human motions for ultimate application in robotics, artificial intelligence and personal healthcare monitoring. 34 The device was composed of a melamine sponge coated with PEDOT/PSS solution.…”

“…Conjugated polymers have been largely used as coatings for implantable sensing devices to provide electrical conductivity, but also to improve the biocompatibility and avoid the scar formation . The inherent characteristic of conductive 3D architectures to be used as electrodes makes interesting materials for biosensing devices . In addition, due to their porous structure, 3D substrates have a much larger surface area for cell and biomolecule attachment, leading to higher biosensing sensitivity and concentration range than the bidimensional architectures.…”

“…Cysewska manufactured also a glucose sensor by electrodeposition of PPy in a Pt surface. The authors obtained nonporous structures with PPy particles with sizes up to the milimiter scale by controlling the deposition charge of the method …”

“…88 The inherent characteristic of conductive 3D architectures to be used as electrodes makes interesting materials for biosensing devices. 89 In addition, due to their porous structure, 3D substrates have a much larger surface area for cell and biomolecule attachment, leading to higher biosensing sensitivity and concentration range than the bidimensional architectures. Ravichandran developed the first injectable electrochemical sensor for in situ monitoring glucose levels in tissue.…”

In-situ odd random phase electrochemical impedance spectroscopy study on the electropolymerization of pyrrole on iron in the presence of sodium salicylate – The influence of the monomer concentration

“…Polypyrrole (PPy) is one of the promising conducting polymers that exhibits very good environmental stability [11], excellent mechanical and thermal properties [11] and high biocompatibility [13]. Due to its unique properties, polypyrrole has been used as advanced coating material in many applications such as anti-corrosive coatings [9,14,15], biosensors [16,17] organic electronics [18] or biomaterials [9,19].…”