Recurrent Pregnancy Loss and Inherited Thrombophilia

Singla, Sumeet; Jain, Sandhya

doi:10.1007/978-981-10-7338-0_9

Cited by 1 publication

(2 citation statements)

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“…Factors Va and VIIIa are important in the coagulation cascade and their inhibition helps to prevent thrombosis, thereby helping to keep blood in a fluid state. Thus deficiencies of Protein C and Protein S results in the development of a procoagulant state [20], thus worsening the procoagulant state already existing in pregnancy. Protein C equally enhances the viability and growth of trophoblast cells [21], thus ensuring foetal survival.…”

Section: Discusionmentioning

confidence: 99%

“…Protein C equally enhances the viability and growth of trophoblast cells [21], thus ensuring foetal survival. This shift to a procoagulant state is evidenced by a reported shift in the thromboxane/prostacycline ratio in favour of thromboxane which is a known prothrombotic agent, resulting in vasospasm and platelet aggregation in the trophoblasts, eventually leading to the development of microthrombi and placental necrosis [20].…”

Section: Discusionmentioning

confidence: 99%

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Assessment of Protein C and Protein S of Pregnancy Loss Victims

Igwe

Charles

Mgbeoma

et al. 2019

IBRR

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Background: The haemostatic changes that result in thrombophilia during the pregnant state have been linked to pregnancy loss. Objective: Assessment of Protein S, and Protein C assays in pregnancy loss victims in Abia State, South East, Nigeria. Materials and Methods: This was a cross-sectional study involving women in their reproductive years. Study population was stratified into 3 groups and the Protein C and Protein S concentrations measured and compared among the three groups. Results: A total of 130 apparently healthy Nigerian women of child-bearing age were enrolled in the study. The study groups consisted of 70 women who had just lost a pregnancy, 30 women with normally progressing pregnancy and 30 nonpregnant women. The protein C concentration for the pregnancy-loss subjects was significantly lower than that of the normal pregnancy at p ≤ 0.01 while that of Protein S showed non-significance (p > 0.05). Conclusion: Protein C deficiency is associated with increase in pregnancy loss.

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Section: Discusionmentioning

confidence: 99%

Section: Discusionmentioning

confidence: 99%