2020
DOI: 10.1186/s40792-020-0790-7
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Recurring radiation-induced angiosarcoma of the breast that was treated with paclitaxel chemotherapy: a case report

Abstract: Background: Angiosarcoma of the breast is very rare and can be divided into primary and secondary angiosarcoma. Radiation-induced angiosarcoma (RIAS) is classified as secondary angiosarcoma. Diagnosis of RIAS is difficult due to its rarity, and the interpretation of pathological imaging is complicated. In the National Comprehensive Care Network (NCCN) guidelines, the first choice of treatment is surgery with negative margins. Adjuvant radiotherapy (RT) for close soft tissue margins should be considered. Preope… Show more

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Cited by 13 publications
(8 citation statements)
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“…In most cases, most patients choose to use adjuvant chemotherapy, but the types and schemes of drugs are diverse, and the curative effect is still uncertain. Paclitaxel can significantly prolong the recurrence-free survival time of patients [19] . In addition, chemotherapy regimens based on anthracycline or epirubicin and ifosfamide can significantly improve disease-free survival and overall survival [20] .…”
Section: Discussionmentioning
confidence: 99%
“…In most cases, most patients choose to use adjuvant chemotherapy, but the types and schemes of drugs are diverse, and the curative effect is still uncertain. Paclitaxel can significantly prolong the recurrence-free survival time of patients [19] . In addition, chemotherapy regimens based on anthracycline or epirubicin and ifosfamide can significantly improve disease-free survival and overall survival [20] .…”
Section: Discussionmentioning
confidence: 99%
“…An oncologic resection alone can fail to provide adequate local control [ 24 ]. Even with uninvolved margins, recurrences may occur owing to the infiltrative nature of RAAS [ 3 , 22 , 25 , 27 , 28 , 36 , 37 ]. The 2 patients in this series who underwent upfront mastectomy (patients 4 and 6) exemplify this problem; despite uninvolved margins, the disease rapidly recurred within 9 weeks after mastectomy.…”
Section: Discussionmentioning
confidence: 99%
“…Treatment intent was curative in all patients and incorporated HART, as previously described [ 3 , 4 , 27 ]. Patients referred after surgery received postoperative HART; however, when possible, we favored preoperative HART as it (1) allows for maximal excision of twice-irradiated tissue; (2) allows for downsizing of the tumor that may facilitate an R0 resection, which is associated with improved outcomes [ 19 ]; and (3) reduces the risk of rapid and early recurrence during convalescence after mastectomy [ 3 , 18 , 22 , 25 , 27 , 28 ].…”
Section: Methodsmentioning
confidence: 99%
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