Recurring Rare Liver Tumor Presenting With Hypoglycemia

Du, Elizabeth H.Y.; Walshe, Triona; Buckley, Anne

doi:10.1053/j.gastro.2014.09.036

Cited by 8 publications

(11 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present case, the patient had complained of repeated abdominal distension for 3 years due to the compression of neighboring structures by the lesion. With the exception of the presence of non-islet cell tumor hypoglycemia syndrome observed in 13 cases (9,16,17,19,22,25,28,31,36,48,60,69,70), the results of laboratory tests for routine biochemical parameters, including aminotransferases or tumor markers, appear normal or slightly, non-specifically altered (33), as was the case with the present patient. Although imaging tests can provide physical characteristics of lesions for clinical analysis, including location and size, the radiological features of an SFT lack specificity, suggesting that none of the aforementioned tests are conclusive.…”

Section: Discussionsupporting

confidence: 60%

Ex situ hepatectomy and liver autotransplantation for a treating giant solitary fibrous tumor: A case report

et al. 2018

View full text Add to dashboard Cite

A solitary fibrous tumor (SFT) is a rare mesenchymal tumor. Ex situ hepatectomy and liver autotransplantation are novel methods for the treatment of complicated liver tumors, for example, those involving vascular structures, including the inferior vena cava, which are unresectable by conventional approaches. The present study describes a rare case of a massive hepatic SFT in a 32-year-old female who underwent ex situ hepatectomy and liver autotransplantation to achieve a radical resection. The surgery was without complications. Post-operative histopathological and immunohistochemical examinations revealed an SFT of the liver. The patient was discharged 29 days after the surgery with fully recovered liver function. The routine check-up 3 months after surgery indicated normal liver function and no evidence of recurrence. Additionally, an exhaustive review of available literature was performed to provide a complete overview of the current status of SFTs. In summary, the present study found that ex situ hepatectomy and liver autotransplantation are suitable surgical techniques for treating a giant SFT, as well as other liver neoplasms that are considered unresectable by conventional surgery.

show abstract

Section: Discussionsupporting

confidence: 60%

Ex situ hepatectomy and liver autotransplantation for a treating giant solitary fibrous tumor: A case report

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Vertebral metastasis 1 month later managed with 4× PEI and 4 rounds of chemo (adriamycin, ifosfamide, mesna). Tumour relapsed and rapidly enlarged with paralysis on 7 months review, patient died 16 months after initial surgery6Belga et al (2012) [70]66/FNilIncrease in abdominal girthR14n/aResection (UM)Mitoses > 4/10 HPF, necrosis, mild nuclear atypiaNADCD34+30 months7Jakob et al (2013) [72]62/FNilUpper abdominal pain and weight lossLn/an/aResection (UM)High cellularity, cytological atypia, necrosis, mitoses 6/10 HPFNADCD34+, CD99+, bcl-2+n/a8Vythianathan and Yong (2013) [74]78/MNilEpigastric painL17 × 13n/aResection (UM)Cellular pleomorphism, necrosis, mitoses > 4/10 HPFn/aCD34+, CD99+, bcl-2+, V+n/a9Song et al (2014) [75]49/MNilAbdominal painL + R7.6 × 5 × 4.8n/aResection (UM)NADn/aCD34+, bcl-2+, V+n/a10Du et al (2015) [56]55/FRecHypoglycaemia and weight lossL15.3 × 15.5 × 15.4n/aResection (UM)n/aNADCD34+, bcl-2+Local recurrence 5 years postsurgery, resected11Feng et al (2015) [20]52/FRecn/aR12n/aResection (UM)Haemorrhage, necrosisNADCD34+Local recurrence 2 years postsurgery on L lobe managed with PEI. New lesion 6 months after PEI12Silvanto et al (2015) [24]65/MNilIncidental findingL18n/aResection (lesion 1–2 mm from margins)Myxoid changes, infarction, necrosis mitoses 5–7/10 HPFNADCD34+, CD99+, bcl-2+16 months13Maccio et al (2015) [46]74/FMetRight abdominal pain and distensionR24 × 16n/a…”

Section: Discussionmentioning

confidence: 99%

“…The size of tumours ranged from 11 to 27 cm and two of the three cases had high rates of mitoses (>9/10 HPF). It is interesting to note that Du et al [56] reports a case on a 55-year-old female with non-malignant SFTL who represented 5 years after initial surgery with local recurrence and associated hypoglycaemia which resolved spontaneously after resection. The tumour did not display any marked variances when compared to other non-malignant SFTLs.…”

Section: Discussionmentioning

confidence: 99%

Solitary fibrous tumour of the liver—report on metastasis and local recurrence of a malignant case and review of literature

Chen

Slater

2017

World J Surg Onc

View full text Add to dashboard Cite

BackgroundSolitary fibrous tumours (SFT) are neoplasms of mesenchymal origin that predominantly arise from the pleura. SFT of the liver (SFTL) are a rare occurrence with little number of cases reported in English literature. Malignant cases of hepatic SFT are an even rarer occurrence. For this reason, the prognostic evaluation of SFTLs is unknown and difficult to measure.MethodsA search on English literature on “Solitary Fibrous Tumour of the Liver” was conducted on common search engines (PubMed, Google). All published articles, case reports and literature reviews and their reference lists were reviewed.Case reportThis paper presents a 61-year-old male who was referred to a tertiary hospital in April 2010 with marked hepatomegaly. USS, CT and MRI scans were suggestive of a neoplasm, and the patient underwent a subsegmental IVb resection in June 2010. The specimen demonstrated histological and immunohistochemical features of malignant SFTL with clear resection margins. The patient was followed up regularly for 3 years with imaging and no suggestion of recurrence. Six years after the initial surgery, the patient represented with worsening right upper quadrant pain and dyspnoea secondary to extensive tumour recurrence adjacent to the resection site and metastatic deposits in the pleura. The patient was managed symptomatically and discharged for community follow-up after palliative involvement.ConclusionsSFTL are rare with only 84 cases reported in the English Literature including the present case. The average age of patients is 57.1 and occurs in females more than males (1.4:1). Most SFTLs follow a benign course, however, 17.9% of cases displayed malignant histological features. Only three cases including the current case are reported to have both local recurrence and metastasis. Surgical resection remains the mainstay of treatment and appears to be curative of most cases. The rarity of this tumour makes it difficult to evaluate its prognosis and natural course.

show abstract

“…We found no descriptions in the English-language literature that resembled that of our patient, who presented with suspected localized liver metastasis from a head SFT. Du et al [21], however, reported a rare case of non-malignant SFT that appeared 5 years after initial liver resection. The tumor’s appearance had no marked variances from other non-malignant SFTs.…”

Section: Discussionmentioning

confidence: 99%

Solitary fibrous tumor in the liver: case report and literature review

et al. 2019

View full text Add to dashboard Cite

Background Solitary fibrous tumors (SFTs) are uncommon mesenchymal neoplasms that present most commonly at intrathoracic sites. SFTs of the liver are rare, with only a few having been reported in the English-language literature. We report a rare case of a hepatic SFT and literature review. Case presentation A 49-year-old woman underwent surgery for a cranial hemangiopericytoma two decades previously. She currently presented with malaise. Abdominal computed tomography (CT) showed a huge, sharply demarcated mass in the anterior segment of the liver. Tumor marker levels were within the normal range. Following central bisegmentectomy of the liver, histological examination of the specimen revealed that the tumor was composed of spindle and fibroblast-like cells with collagenous stroma. Immunohistochemically, the spindle cells were negative for CD34 but positive for STAT6. The NAB2–STAT6 fusion gene was detected by the reverse transcription polymerase chain reaction. A diagnosis of SFT was thus confirmed histopathologically and genetically. Conclusions The SFT of the liver is an uncommon finding. Because there are no specific imaging features, it is difficult to diagnose the hepatic SFT preoperatively. We consider that careful surgical resection and postoperative follow-up are necessary for hepatic SFTs.

show abstract

Recurring Rare Liver Tumor Presenting With Hypoglycemia

Cited by 8 publications

References 3 publications

Ex situ hepatectomy and liver autotransplantation for a treating giant solitary fibrous tumor: A case report

Ex situ hepatectomy and liver autotransplantation for a treating giant solitary fibrous tumor: A case report

Solitary fibrous tumour of the liver—report on metastasis and local recurrence of a malignant case and review of literature

Solitary fibrous tumor in the liver: case report and literature review

Contact Info

Product

Resources

About