Recyclable menthol-based deep eutectic solvent micellar system for extracting phytochemicals from Ginkgo biloba leaves

Wang, Litao; Yang, Qing; Cui, Qi; Fan, Xiao-Hong; Dong, Mingzhu; Gao, Ming‐Zhu; Lv, Mu-Jie; An, Juan-Yan; Meng, Dong; Zhao, Xiuhua; Fu, Yujie

doi:10.1016/j.jclepro.2019.118648

Cited by 52 publications

(32 citation statements)

References 42 publications

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“…So the extraction of the three target compounds was suitable for hydrophobic DES extraction. Following methods used in previous reports [ 32 , 33 ], we selected six organic acids and alcohols that can form eutectic mixtures with L-menthol as components of DESs. These compounds include acetic acid, lactic acid, levulinic acid, n -propanol, isopropanol and tert -butanol, as shown in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…The results showed that L-Men-Lac was suitable for the extraction of tryptanthrin, indigo and indirubin from BCL. According to reports in the literature [ 33 , 42 , 43 ], the ultrasound-assisted extraction method based on DES can also be used to extract representative phytochemical constituents from Ginkgo biloba leaves, including flavonoid glycosides, terpenoids and flavonoids, phytocannabinoids from the Cannabis sativa plant and lycopene from the by-product of tomato processing. Combined with experimental results and literature, L-Men-Lac was used for subsequent experiments.…”

Section: Resultsmentioning

confidence: 99%

“…Some new DESs that are based on the combination of menthol with alcohols and organic acids have been synthesized. These DESs showed a high degree of hydrophobicity, which indicated that menthol was a good candidate for the preparation of hydrophobic DESs [ 32 , 33 ]. Menthol can be extracted from plants in the genus mentha and has a wide range of sources.…”

Section: Introductionmentioning

confidence: 99%

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Optimization of Extraction of Bioactive Compounds from Baphicacanthus cusia Leaves by Hydrophobic Deep Eutectic Solvents

Cai

et al. 2021

Molecules

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Deep eutectic solvents (DESs) are considered as efficient and green solvents for the extraction of bioactive compounds from medicinal plants. In this work, a novel method of DES-based ultrasound-assisted extraction of bioactive compounds from Baphicacanthus cusia leaves (BCL) was established. Systematic screening and the morphology of the original and treated BCL were observed with scanning electron microscopy to determine the extraction efficiency of different solvents. The extraction conditions were optimized by Box–Behnken design (BBD) tests and the optimal extraction conditions were as follows: lactic acid/L-menthol ratio of 5: 2 (mol/mol), solid–liquid ratio of 80.0 mL/g and temperature of 60.5 °C. The extraction yields of tryptanthrin, indigo and indirubin reached 0.356, 1.744 and 0.562 mg/g, respectively. The results of a 2,2-diphenyl-1-picrylhydrazy (DPPH) radical scavenging activity test indicated the feasibility of DESs in the extraction of bioactive compounds. This study indicated that L-menthol/lactic acid was a green and efficient solvent for the extraction of bioactive compounds from BCL, and DES-based ultrasound-assisted extraction could be used as an effective application strategy for the extraction of bioactive compounds from medicinal plants.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Optimization of Extraction of Bioactive Compounds from Baphicacanthus cusia Leaves by Hydrophobic Deep Eutectic Solvents

Cai

et al. 2021

Molecules

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“…However, Křížek et al have, for the first time, introduced the use of tailor-made hydrophobic DES as extraction media for the isolation of various phytocannabinoids from Cannabis sativa [84]. This is a relatively new field of research and only a few papers have been published up to date [85,86]. Since hydrophobic DES components are not miscible with water, an alternative method is required to adjust their physical-chemical properties.…”

Section: Short Historical Overview Of Development and Use Of Des/nadesmentioning

confidence: 99%

“…Since hydrophobic DES components are not miscible with water, an alternative method is required to adjust their physical-chemical properties. In the both published articles, menthol-based DES were used to isolate the most important phytochemicals from the leaves of the Ginkgo biloba, and properties of DES was tuned by mixing two or more different hydrophobic solvents [85,86]. Cao et al have also published an interesting paper describing the simultaneous extraction of hydrophilic and hydrophobic bioactive compounds from the leaves of Ginkgo biloba [87].…”

Section: Short Historical Overview Of Development and Use Of Des/nadesmentioning

confidence: 99%

Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

Ivanović

Razboršek

Kolar

2020

Plants

124

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The growing interest of the food, pharmaceutical and cosmetics industries in naturally occurring bioactive compounds or secondary plant metabolites also leads to a growing demand for the development of new and more effective analysis and isolation techniques. The extraction of bioactive compounds from plant material has always been a challenge, accompanied by increasingly strict control requirements for the final products and a growing interest in environmental protection. However, great efforts have been made in this direction and today a considerable number of innovative extraction techniques have been developed using green, environmentally friendly solvents. These solvents include the deep eutectic solvents (DES) and their natural equivalents, the natural deep eutectic solvents (NADES). Due to their adjustable physical-chemical properties and their green character, it is expected that DES/NADES could be the most widely used solvents in the future, not only in extraction processes but also in other research areas such as catalysis, electrochemistry or organic synthesis. Consequently, this review provided an up-to-date systematic overview of the use of DES/NADES in combination with innovative extraction techniques for the isolation of bioactive compounds from various plant materials. The topicality of the field was confirmed by a detailed search on the platform WoS (Web of Science), which resulted in more than 100 original research papers on DES/NADES for bioactive compounds in the last three years. Besides the isolation of bioactive compounds from plants, different analytical methods are presented and discussed.

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Microwave‐ultrasonic technique development coupled with natural deep eutectic solvents in anthocyanin extraction from perilla leaves (Perilla frutescens var. Acuta)

et al. 2022

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Background As potent antioxidants, anthocyanins can protect the body from free radicals. However, the traditional solvent extraction method has the disadvantages of requiring a high extraction temperature and long extraction time, so it is necessary to develop an efficient extraction method for anthocyanins. Results In this study, the technique of natural deep eutectic solvents (DESs) was applied to extract anthocyanins from purple perilla leaves with the aid of microwave‐ultrasonic assisted extraction (MUAE). The response surface methodology (RSM), based on the Box–Behnken design (BBD), predicted the maximum extraction yield of anthocyanins to be 619.62 mg (100 g)−1 under the following conditions: x1 (ultrasonic extraction power) = 357.25 W, x2 (time) = 25.62 min, and x3 (temperature) = 57.80 °C. The biological activity of the extract obtained was evaluated by examining its radical‐scavenging effect on 1,1‐diphenyl‐2‐picrylhydrazyl, hydroxyl radical, and superoxide anion radicals. Its bacteriostatic impact was investigated on four typical bacteria: Shewanella putrefaciens (S. putrefaciens), Pseudomonas fluorescens (P. fluorescens), Escherichia coli (E. coli), and Staphylococcus aureus (S. aureus). Conclusion The integrated extraction method of DESs with MUAE was efficient, energy‐saving, green, and sustainable. © 2022 Society of Chemical Industry.

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Recyclable menthol-based deep eutectic solvent micellar system for extracting phytochemicals from Ginkgo biloba leaves

Cited by 52 publications

References 42 publications

Optimization of Extraction of Bioactive Compounds from Baphicacanthus cusia Leaves by Hydrophobic Deep Eutectic Solvents

Optimization of Extraction of Bioactive Compounds from Baphicacanthus cusia Leaves by Hydrophobic Deep Eutectic Solvents

Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

Microwave‐ultrasonic technique development coupled with natural deep eutectic solvents in anthocyanin extraction from perilla leaves (Perilla frutescens var. Acuta)

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