Red and Near‐Infrared Light‐Cleavable Polymers

Zeng, Xiaolong; Zhou, Xuechang; Wu, Si

doi:10.1002/marc.201800034

Cited by 37 publications

(37 citation statements)

References 89 publications

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“…For example, near-infrared (nIR) light detachable adhesion may be realized by introducing the nIR light cleavable moiety like o-nitrobenzyl or coumarin into the backbone of the stitching polymer. [47] As the nIR light is not significantly absorbed by most biomaterials, detachment in response to nIR light may enable new medical procedures. All these examples motivate further development of photodetachable adhesion.…”

mentioning

confidence: 99%

Photodetachable Adhesion

2018

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covalent bonds is typically hard to remove. Adhesion through physical interactions may be detachable, but usually requires solvents to act at the bonding front [25,30] ; the operation can be time-consuming and environmentally harmful. Some traditional adhesives are chemically modified to be detachable upon a change in temperature (e.g., epoxy) [31,32] or an exposure of light (e.g., pressure-sensitive adhesive), [23,33] but they are usually cytotoxic and ineffective for wet materials like hydrogels and living tissues. Some bioinspired adhesion systems also use noncontact stimuli like temperature or magnetic field to trigger detachment. [34][35][36] Nevertheless, their adhesions rely on specific materials with special surface geometry, or generate low adhesion energy (1-10 J m −2 ). Achieving both strong adhesion and easy detachment has been a challenge.Here we describe an approach to achieve both strong adhesion and lighttriggered easy detachment. We first describe the principle of strong and photodetachable adhesion using two hydrogels as adherends (Figure 1). Each hydrogel aggregates water molecules and a covalent polymer network. The polymer networks in the two hydrogels have no matching functional groups for bonding, so that the two hydrogels by themselves adhere poorly. We achieve strong adhesion by spreading an aqueous solution of polymer chains on the surfaces of the two hydrogels, and triggering the polymer chains to cross-link into a third polymer network in situ, in topological entanglement with the preexisting polymer networks of the two hydrogels. The third polymer network acts as a molecular suture that stitches the two preexisting polymer networks of the hydrogels together. This process is called topological adhesion, or topohesion for short. [25] We achieve photodetach by functionalizing the stitching polymer network for photodetach, and triggering the network to dissociate upon an exposure to light of a certain frequency range.The principle described above requires two triggers. The first trigger, which we call the topohesion-trigger, causes the stitching polymer chains to cross-link into a new polymer network in topological entanglement with the preexisting polymer networks of the two hydrogels. The second trigger, which we call the photodetach-trigger, causes the stitching network to dissociate in response to light of certain frequency range. Conceivably the two triggers can be realized with various chemistries. Here we demonstrate topohesion and photodetach using two facts of chemistry: 1) Fe 3+ ions and carboxyl groups form coordination complexes, [37,38] and 2) the coordination complexes

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confidence: 99%

Photodetachable Adhesion

2018

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“…Over the last couple of decades, o ‐nitrobenzyl and other photocleavable groups have been investigated as polymer pendant groups (Figure a), backbone moieties, and as cross‐linkers in networks and hydrogels . In addition, while many photolabile groups require UV light for bond cleavage, significant efforts have recently been undertaken to use red or near‐infrared light in combination with one‐photon photochemistry, two‐photon absorption, or upconverting nanoparticles …”

Section: Selected Developments In Smart Polymersmentioning

confidence: 99%

“…[35][36][37] In addition, while many photolabile groups require UV light for bond cleavage, significant efforts have recently been undertaken to use red or near-infrared light in combination with one-photon photochemistry, two-photon absorption, or upconverting nanoparticles. [40] Photochromic moieties undergo light-induced reversible switching between two isomeric forms. Mechanisms such as cis-trans isomerization, pericyclic reactions, and intramolecular hydrogen transfers or group transfers can be involved, [41] and are often accompanied by a color change, as well as changes in physical and chemical properties of the photochromic moiety such as geometrical structure, dipole moment, and refractive index.…”

Section: Classes Of Smart Polymersmentioning

confidence: 99%

Reflections on the Evolution of Smart Polymers

Gillies

2019

Israel Journal of Chemistry

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Since Staudinger's recognition that polymers were long chain molecules with covalent bonds between repeating units, the field has evolved tremendously. In addition to their many structural roles, polymers have been developed to exhibit “smart” stimuli‐responsive behavior. This article will describe the evolution of selected classes of smart polymers including those responsive to changes in pH, temperature, light, and mechanical stimuli, as well as self‐immolative polymers and their application in drug delivery, sensors, and actuators. It will also highlight key advancements in polymer chemistry that enabled rapid progress over the past ∼20 years. Whether the key achievements were predictable will be discussed, and the extent to which polymer science remains an independent science versus a service tool will be addressed. Finally, some possibilities for the evolution of the field over the next 20–30 years will be described.

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“…In truth, any number of photons can be used if the sum of their energy equals that of a specific photon energy. In this way, it is possible to achieve a high energy reaction using lower energy radiation . In other words, two or more NIR photon can be used instead of a single Vis or UV light photon.…”

Section: Effect Of Light On Biomedical Applicationsmentioning

confidence: 99%

The Role of Photochemical Reactions in the Development of Advanced Soft Materials for Biomedical Applications

Fernandez‐Villamarin

Brooks

Mendes

2019

Advanced Optical Materials

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In the biomedical field, many innovative materials to improve diagnosis and treatment of diseases are currently being developed. The ability to respond to different stimuli is one of the more interesting properties of such materials. Light, as one of the nature's elementary stimuli, offers an attractive and flexible stimulus for controlling the properties and functions of biomedical‐related materials. As such, photoresponsive systems have been increasingly pursued and finding applications in various biomedical settings, ranging from tissue engineering for the fabrication of bespoke tissue scaffolds to drug delivery, aims at manipulating treatment distribution inside the human body. Efforts have also been devoted to the development of highly efficient methods to control biological activity and bring us closer to mimicking impressive biological actuators. In this progress report, an overview of recent developments in the field is provided and current challenges discussed. Key strategies tailored to address specific issues are examined, offering useful perspectives for future designs.

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Red and Near‐Infrared Light‐Cleavable Polymers

Cited by 37 publications

References 89 publications

Photodetachable Adhesion

Photodetachable Adhesion

Reflections on the Evolution of Smart Polymers

The Role of Photochemical Reactions in the Development of Advanced Soft Materials for Biomedical Applications

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