Red blood cell aggregate flux in a bifurcating microchannel

Kaliviotis, Efstathios; Pasias, Dimitris; Sherwood, JM; Balabani, Stavroula

doi:10.1016/j.medengphy.2017.04.007

Cited by 16 publications

(11 citation statements)

References 29 publications

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“…The observed hematocrit distributions are expected to have an impact on partitioning of RBC suspensions in bifurcations and the downstream organization of the suspension, as has been demonstrated with aggregated RBC suspensions [1][2][3]37,52 and also by the inversion of hematocrit partitioning in bifurcations found by Shen et al 30 for dilute suspensions of RBCs with altered deformation characteristics. The concentration of hardened RBCs toward the axis of the channels would likely enhance the Fåhraeus effect and plasma skimming, causing low flow rate vessels to receive fewer cells and high flow rate ones more, potentially making them more prone to jamming as cells are less deformable.…”

Section: Articlementioning

confidence: 63%

The effect of deformability on the microscale flow behavior of red blood cell suspensions

et al. 2019

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Red blood cell (RBC) deformability is important for tissue perfusion and a key determinant of blood rheology. Diseases such as diabetes, sickle cell anemia, and malaria, as well as prolonged storage, may affect the mechanical properties of RBCs altering their hemodynamic behavior and leading to microvascular complications. However, the exact role of RBC deformability on microscale blood flow is not fully understood. In the present study, we extend our previous work on healthy RBC flows in bifurcating microchannels [Sherwood et al., "Viscosity and velocity distributions of aggregating and non-aggregating blood in a bifurcating microchannel," Biomech. Model. Mechanobiol. 13, 259-273 (2014); Sherwood et al., "Spatial distributions of red blood cells significantly alter local hemodynamics," PLoS One 9, e100473 (2014); and Kaliviotis et al., "Local viscosity distribution in bifurcating microfluidic blood flows," Phys. Fluids 30, 030706 (2018)] to quantify the effects of impaired RBC deformability on the velocity and hematocrit distributions in microscale blood flows. Suspensions of healthy and glutaraldehyde hardened RBCs perfused through straight microchannels at various hematocrits and flow rates were imaged, and velocity and hematocrit distributions were determined simultaneously using micro-Particle Image Velocimetry and light transmission methods, respectively. At low feed hematocrits, hardened RBCs were more dispersed compared to healthy ones, consistent with decreased migration of stiffer cells. At high hematocrit, the loss of deformability was found to decrease the bluntness of velocity profiles, implying a reduction in shear thinning behavior. The hematocrit bluntness also decreased with hardening of the cells, implying an inversion of the correlation between velocity and hematocrit bluntness with loss of deformability. The study illustrates the complex interplay of various mechanisms affecting confined RBC suspension flows and the impact of both deformability and feed hematocrit on the resulting microstructure.

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Section: Articlementioning

confidence: 63%

The effect of deformability on the microscale flow behavior of red blood cell suspensions

et al. 2019

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“…The concentration of RBCs in the plasma, which is the continuous phase of the fluid, plays a part in rendering blood a non-Newtonian fluid. In that case, the thinning and atrophy of retinal and choroidal blood vessels in patients with RP may lead to blood flow in high stress cases, resulting in microcirculatory hypoperfusion, tissue ischemia, and hypoxia [19]. However, the tendency of RBCs to aggregate mainly causes the increase of blood viscosity [16].…”

Section: Discussionmentioning

confidence: 99%

Investigation of Blood Characteristics in Nonsyndromic Retinitis Pigmentosa: A Retrospective Study

Yang

Deng

Tian

et al. 2019

Journal of Ophthalmology

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Purpose. To investigate the characteristics of blood in nonsyndromic retinitis pigmentosa (RP) and reveal the pathogenesis of blood cells involved in blood stasis in RP.Design. This is a retrospective observational study.Methods. We collected vein blood from 101 cases of patients with nonsyndromic RP and 120 cases of normal individuals according to a single-blind study and used routine clinical examination to detect the indicators of blood. All the subjects were mainly from the central south of China. Data were analyzed statistically between the RP group and normal control.Results. The indicator of platelet distribution width (PDW) in patients with RP was higher than that in the normal group; the indicators of red blood cell (RBCs), hemoglobin (HGB), hematocrit (HCT), basophils (BASs), platelets (PLTs), and plateletcrit (PCT) in the RP group were lower than those in the normal control. The differences were statistically very significant between the RP group and normal group (p<0.01). There were no statistical differences in the other indicators between the RP and normal group.Conclusions. The changes in RBCs and PLTs in patients with RP implied that RP induces RBC aggregation and platelet activation, leading to blood stasis which in turn initiates more apoptosis.

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“…In addition, the current model does not consider the non‐Newtonian phenomena of blood rheology, eg, shear thinning, history effects, hysteresis, and structural aggregates. These effects can be required in accurately predicting the blood flow in the microvasculature . In this reason, the non‐Newtonian effects can be a part of future work as well.…”

Section: Discussionmentioning

confidence: 99%

A computational modeling of blood flow in asymmetrically bifurcating microvessels and its experimental validation

Lee

Hong

Yoo

et al. 2018

Numer Methods Biomed Eng

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Microvascular transport is complex due to its heterogeneity. Many researchers have been developing mathematical and computational models in predicting microvascular geometries and blood transport. However, previous works were focused on developing simulation models, not on validating suggested models with microvascular geometry and blood flow in the real microvasculature. In this paper, we suggest a computational model for microvascular transport with experimental validation in its geometry and blood flow. The geometry is generated by controlling asymmetric conditions of microvascular network. Also, the blood flow in microvascular networks is predicted by considering in vivo viscosity, Poiseuille flow model, and hematocrit redistribution by plasma skimming. The suggested model is validated by the measured data in rat mesentery. Also, the microvascular transport in a case of mouse cortex is predicted and compared against experimental data to check applicability of the suggested model.

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Red blood cell aggregate flux in a bifurcating microchannel

Cited by 16 publications

References 29 publications

The effect of deformability on the microscale flow behavior of red blood cell suspensions

The effect of deformability on the microscale flow behavior of red blood cell suspensions

Investigation of Blood Characteristics in Nonsyndromic Retinitis Pigmentosa: A Retrospective Study

A computational modeling of blood flow in asymmetrically bifurcating microvessels and its experimental validation

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