Red Blood Cell Aggregation and Deformability among Patients Qualified for Bariatric Surgery

Wiewióra, Maciej; Sosada, Krystyn; Wyleżoł, Mariusz; Słowińska, Ludmiła; Żurawiński, Wojciech

doi:10.1007/s11695-007-9066-6

Cited by 26 publications

(14 citation statements)

References 21 publications

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“…In the study carried out by Wiewiora et al [31] in 40 patiens qualified for bariatric surgery in whom ED was measured with the LORCA (Laser-assisted optical rotational cell analyzer), a similar device as the Rheodyn SSD used in the present study, ED was found to be decreased when compared with a normalweight group. The authors only performed the Pearson bivariate correlation between ED and several lipidic parameters, founding a correlation between ED and TG although they did not indicate whether the correlation was positive or negative.…”

Section: Discussionsupporting

confidence: 46%

“…In this sense, most studies have been performed in patients with obesity grade I or II with conflicting results [2,7,10,12,16,19,20,28,33]. However, scarce information exists regarding ED in patients exclusively with morbid obesity [13,31,32]. In this respect the authors [31] have found a decreased ED but the cause is uncertain, as no multivariate regression analysis that allow to know the independent association of diverse parameters with ED have been performed.…”

Section: Introductionmentioning

confidence: 99%

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Erythrocyte deformability in morbid obesity before bariatric surgery. Influence of abdominal obesity

Vayá

Cámara

Hernádez-Mijares

et al. 2010

Clinical Hemorheology and Microcirculation

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Although there are several studies dealing with erythrocyte deformability (ED) in obese patients, research on this topic in morbidly obese subjects is scarce. In these studies ED seems to be decreased, although the cause remains unknown.A case-control study in 76 morbid obese subjects (23 women and 53 men, aged 44 ± 13 years) and in 79 normal-weight controls (30 women and 49 men, aged 43 ± 13 years) was undertaken. ED has been determined by ektacytometric techniques in a Rheodyn SSD, by means of the elongation index (EI) at 12, 30 and 60 Pascals, along with anthropometric, lipidic, metabolic and inflammatory parameters.EI was statistically lower in morbidly obese subjects than in controls at all the shear stresses tested (EI12: 47.3 ± 2.14 vs. 47.9 ± 2.07; p = 0.047, EI30: 52.16 ± 2.1 vs. 53.12 ± 1.4; p = 0.007, EI60: 53.9 ± 2.4 vs. 55.2 ± 2.50; p = 0.001) as were anthropometric lipidic and inflammatory parameters (p < 0.001). In the bivariate correlation EI60 correlated negatively with most anthropometric, lipidic and inflammatory parameters. However, in the multivariate analysis, the case-control status was not significantly associated with EI60 and only triglycerides, glucose, hs-CRP and waist circumference were independently associated with EI60, constituting independent predictors of altered ED although, waist circumference, showed the highest statistical significance (p = 0.007).ED is decreased in morbidly obese subjects associated with insulin resistance and inflammation parameters although abdominal obesity seems to be of paramount importance in altering this rheological parameter.

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Section: Discussionsupporting

confidence: 46%

Section: Introductionmentioning

confidence: 99%

Erythrocyte deformability in morbid obesity before bariatric surgery. Influence of abdominal obesity

Vayá

Cámara

Hernádez-Mijares

et al. 2010

Clinical Hemorheology and Microcirculation

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“…Valensi confirmed a decrease of erythrocyte deformability expressed in the RBC index of filtration in normotensive and hypertensive obese patients compared to controls, but there were no significant differences between both obese groups [18]. The results of our previous study showed that obesity is associated with RBC rheological disturbances expressed by a decrease in RBC deformability, increased total aggregation extent and the alteration of kinetics of RBC aggregation [20]. Disturbances of RBC aggregation (aggregation index and aggregation half-time) were especially marked in diabetic obese patients.…”

Section: Discussionmentioning

confidence: 55%

“…However, there was no such relationship between other rheological properties and waist/hip ratio. The studies showed no differences in plasma viscosity and red blood cell filterability between android and gynoid obese women [20]. Another study also confirmed that erythrocyte aggregation index and plasma viscosity was similar regardless of WHR differences [14].…”

Section: Discussionmentioning

confidence: 78%

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Sex-dependent differences in rheological properties and the relation of blood viscosity to erythrocyte aggregation indices among morbidly obese patients

Wiewióra

Sosada

Słowińska

et al. 2010

Clinical Hemorheology and Microcirculation

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Some studies indicate that obesity is associated with rheological disturbances. Because there are usually sex differences in the type of obesity we decided to evaluate rheological differences between male and female obese patients. We studied 18 morbidly obese men, mean age 43.66 ± 11.32 years, mean body mass index (BMI) 49.82 ± 6.03 kg/m 2 and 20 obese females, mean age 40.6 ± 11.86 years, mean BMI 47.41 ± 8.81 kg/m 2 . Blood and plasma viscosity measurements were performed using a cone-plate viscometer (Brookfield DV-II). Erythrocyte elongation and red blood cell (RBC) aggregation were measured using the Laser-assisted Optical Rotational Cell Analyser (LORCA).Whole blood viscosity and RBC deformability expressed by the elongation index were significantly higher in obese men. We did not observe differences in plasma viscosity, corrected blood viscosity and aggregation parameters among the obese population. Blood viscosity correlated with selected RBC aggregation indices.We conclude that morbidly obese patients presented sex-dependent differences in some rheological properties. This study indicates a relation between erythrocyte aggregation indices and blood viscosity in obese populations.

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Nano-Mechanical Response of Red Blood Cells

Papi

Ciasca

Palmieri

et al. 2016

Mechanics of Biological Systems and Materials, Volume 6

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Red Blood Cell Aggregation and Deformability among Patients Qualified for Bariatric Surgery

Cited by 26 publications

References 21 publications

Erythrocyte deformability in morbid obesity before bariatric surgery. Influence of abdominal obesity

Erythrocyte deformability in morbid obesity before bariatric surgery. Influence of abdominal obesity

Sex-dependent differences in rheological properties and the relation of blood viscosity to erythrocyte aggregation indices among morbidly obese patients

Nano-Mechanical Response of Red Blood Cells

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