Red blood cell antibody screening in pregnancy

Devi, Shanthala; Alwar, Vanamala; Sitalakshmi, S; Rameshkumar, Karuna; Mhaskar, Rita

doi:10.4103/0973-6247.76002

Cited by 12 publications

(11 citation statements)

References 5 publications

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“…Out of 2060 mothers, history of blood transfusion was present in 14 (0.7%) women but none had alloantibodies. Prevalence of alloimmunization among pregnant women documented in various published studies [8][9][10][13][14][15][16] and the present study is shown in Table 6.…”

Section: Methodsmentioning

confidence: 76%

“…These were identified as anti-D antibodies (n = 6, 66%), Anti-D with anti-C antibodies (n = 2, 22%), and anti-M antibody (n = 1, 11%). 9 In our study, we identified 3 (13.6%) antenatal women with a combination of anti D and anti C; out of which two caused a HDFN. Anti C alone is rare; usually it is associated with either anti D or anti E. 28 A statistically significant correlation has been reported between the rate of alloimmunization and adverse obstetric history and also with the gravid status of the women.…”

Section: Discussionmentioning

confidence: 99%

“…28 In one study 10 10.1% and 7.6% of the antibodies were observed to be anti-Le a and Le b respectively. 10 In a prospective study 9 carried out on 624 antenatal cases, red cell antibody screening was positive in 9 (1.4%) of the 624 cases. These were identified as anti-D antibodies (n = 6, 66%), Anti-D with anti-C antibodies (n = 2, 22%), and anti-M antibody (n = 1, 11%).…”

Section: Discussionmentioning

confidence: 99%

“…Few studies from New Delhi, Tamil Nadu and Karnataka have reported frequency of these unexpected antibodies as 1.3%, 1.5% and 1.4% respectively. [8][9][10] No such reports are available from Andhra Pradesh. Timely detection of such antibodies in antenatal women will be essential both for transfusion safety in mother and early management of HDFN.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of “unexpected antibodies” in the antenatal women attending the Government Maternity Hospital, Tirupati

et al. 2015

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Background: All antibodies to red cell antigens, other than naturally occurring anti-A and anti-B are considered unexpected. They can be either alloantibodies or auto antibodies. In pregnant women, these antibodies may cross the placenta and cause haemolytic disease of the foetus and newborn (HDFN). Timely detection of such antibodies in antenatal women is essential for early management of HDFN. Methods: A prospective cross-sectional study was carried out on 2060 multiparous pregnant women attending the Government Maternity Hospital, Tirupati to detect prevalence of unexpected antibodies. The women were grouped and typed for ABO and rhesus (Rh) D antigens by tube method and screened for alloantibodies by column agglutination technology. The medical and detailed obstetric history of these women were reviewed. Results: The overall prevalence of alloantibodies was 1.1%. There was a statistically significant difference between alloimmunization rates in the Rh D-antigen negative and D-antigen positive women (12.8% versus 0.3%). The antibodies detected in this study were, anti-D (63.8%), anti-D+C (13.7%), anti-C, anti-E, anti-M, anti-Le a , and anti-Le b (4.5% each). Anti-D contributed to 77.3% of total alloimmunization in this study. Conclusions:In spite of the introduction of prophylactic Rh-immunoglobulin, anti-D (77.3%) is still a common antibody identified in the antenatal women of our region. In developing countries like India, universal antenatal antibody screening, though desirable may not be justified at present as the cost and infrastructure required would be immense. However, it is necessary to impose properly formulated protocols to screen at least the pregnant women with adverse obstetric history.

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Section: Methodsmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevalence of “unexpected antibodies” in the antenatal women attending the Government Maternity Hospital, Tirupati

et al. 2015

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“…14 A prospective South Indian study carried out in 624 antenatal women gave a positive antibody screen in 9 cases (1.44%); anti-D-6 (0.96%), anti-D with anti-c-2 (0.32%) and anti-M-1 (0.16%). 15 A study conducted in same setting among 2469 D negative females showed a D-alloimmunisation of 3.12% and frequency of Rh-D HDFN was 2.28%. 16 Singhvi Arpita et al studied distribution of neonatal jaundice due to blood group incompatibility.…”

Section: Discussionmentioning

confidence: 99%

Frequency of Antibodies in Haemolytic Disease of Foetus and Newborn

Vilambil¹,

Dharmadas²,

Usha³

et al. 2017

jemds

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BACKGROUNDHaemolytic disease of foetus and newborn (HDFN) is triggered by enhanced destruction of red blood cell due to immune-mediated destruction, intrinsic abnormalities, acquired aberrations, etc. Lifespan of infant's erythrocytes are shortened by the action of placentally transferred maternal antibodies in immune-mediated HDFN.The aim of this study was to identify the frequency of maternal antibodies in neonates with hyperbilirubinaemia. Settings and Design-This was a cross-sectional study in neonates admitted to neonatal intensive care unit (NICU). Setting for the research was Dept. of Transfusion Medicine and Neonatology division of Sree Avittom Thirunal Hospital for women and children attached to Govt. Medical College, Trivandrum.

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Frequency of Red Cell Alloantibodies in Pregnant Females of Navsari District: An Experience that Favours Inclusion of Screening for Irregular Erythrocyte Antibody in Routine Antenatal Testing Profile

Kahar¹

2017

J Obstet Gynecol India

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Red cell alloimmunisation is not uncommonly observed in pregnant females; the information gained can help the obstetrician to identify high-risk cases to timely start antenatal and post-natal treatment. Obstetricians should request screening for irregular red cell antibody desirably in all pregnant females; however, if limiting factors are there, it should be done at least in select group of pregnant females having bad obstetric history.

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Red blood cell antibody screening in pregnancy

Cited by 12 publications

References 5 publications

Prevalence of “unexpected antibodies” in the antenatal women attending the Government Maternity Hospital, Tirupati

Prevalence of “unexpected antibodies” in the antenatal women attending the Government Maternity Hospital, Tirupati

Frequency of Antibodies in Haemolytic Disease of Foetus and Newborn

Frequency of Red Cell Alloantibodies in Pregnant Females of Navsari District: An Experience that Favours Inclusion of Screening for Irregular Erythrocyte Antibody in Routine Antenatal Testing Profile

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