Red blood cell distribution width predicts prognosis in idiopathic sudden sensorineural hearing loss

Abstract

Background: Although the red blood cell distribution width (RDW) has been reported as a reliable predictor of prognosis in several types of cancer, the prognostic value of RDW in hilar cholangiocarcinoma (HC) has not been studied. Methods: A retrospective analysis of 292 consecutively recruited HC patients undergoing radical resection was conducted. The optimal cutoff value of RDW was determined by the receiver operating characteristic curve (ROC). Survival analysis by the Kaplan-Meier method, the difference between the clinico-pathologic variables and survival were evaluated by log-rank analysis. Multivariate analysis identified independent prognostic risk factors of overall survival (OS). Results: ROC analysis suggested that the optimal cutoff value for the RDW was 14.95. Linear correlation analysis revealed that RDW is associated with white blood cell count (P = 0.007), neutrophil-to-lymphocyte ratio (P = 0.02), and hemoglobin (P < 0.001), albumin (P < 0.001). In a multivariate analysis, the RDW was an independent prognostic factor for OS (HR = 1.755, 95% CI 1.311-2.349, P < 0.001). Conclusions: Elevated RDW may be regarded as an indicator of systemic inflammatory response which might facilitate HC growth and metastasis. Current evidence suggests that RDW may have clinical significance in predicting OS after surgery in HC patients.

Neutrophil-to-lymphocyte ratio predicts diagnosis and prognosis of idiopathic sudden sensorineural hearing loss

“…The therapeutic regimen, follow-up period, and recovery condition were reported in all these 12 studies. Nine studies applied the Siegel criteria as the hearing improvement criteria, which defined ISSHL patients with more than 15 dB hearing gain after treatment as “recovered” patients, [ 25 – 27 , 29 , 31 , 35 ] whereas 3 studies used a non-Siegel criteria to classify the curative response, which regarded ISSHL cases with more than 10 dB hearing gain after therapy as “recovered” patients. [ 30 , 34 , 36 ] According to the quality assessment, all cohort studies had scores of 7 or more and were of high quality (Supplement Table 2).…”

Biomarkers Suggesting Favorable Prognostic Outcomes in Sudden Sensorineural Hearing Loss

“…RDW may also be a biomarker in patients with SSNHL, being significantly higher in SSNHL patients who did not recover than those who did recover after treatment ( p = 0.031). Moreover, RDW and hearing recovery showed a significant negative correlation ( p = 0.03, r = −0.24), suggesting that RDW may be a significant prognostic factor in patients with SSNHL [ 66 ].…”

Coagulation States in Patients With Sudden Sensorineural Hearing Loss Evaluated by Thromboelastography

“…The reason is probably that different subgroups of SSNHL have different pathologic backgrounds. 13,17,36 Nonetheless, all patients have normal coagulation function, so they should not be routinely treated with defibrinogenation therapy.…”