Red blood cell distribution width and the risk of being in poor glycemic control among patients with established type 2 diabetes

Yin, Yaqi; Ye, Sisi; Wang, Haibin; Li, Bing; Wang, Anping; Yan, Wenhua; Dou, Jingtao; Mu, Yiming

doi:10.2147/tcrm.s155753

Cited by 24 publications

(30 citation statements)

References 40 publications

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“…These results are similar to our study. Another study done by Yin et al (2018) revealed a noteworthy association between RDW and the risk of being in poor glycemic control among Type 2 diabetes mellitus subjects, which is on par with the results of our study. Chowta et al (2013) studied the hemogram pro ile of 2 groups of elderly diabetics < 60 years &> 60 years and found that the RDW of patients > 60 years had a higher value than the younger group which was statistically signi icant ( p-value 0.002 )which can be correlated with our study.…”

Section: Figure 3: Distribution Of the Study Population By Age And Hba1csupporting

confidence: 91%

Correlation of Red Blood Cell Distribution Width (RDW) and Hemoglobin A1C (HbA1c) Levels, In Patients with Type 2 Diabetes Mellitus

Biswas

Chitra

2020

ijrps

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The incidence of Diabetes Mellitus is increasing worldwide, with almost 1/3 of adults being affected. It is the major contributor to the morbidity of a man with its multi-organ system complications. Control of blood glucose levels is vital to decrease organ damage and complications. Routine diagnostic tests conducted are blood glucose, lipid pro ile, renal function tests, HbA1c, and insulin assays with a baseline CBC (Complete Blood Count). HbA1c values continue to be the gold standard for the assessment of glycemic control. The RDW (Red Cell Distribution Width) is a parameter of Complete Blood Count. Several studies have shown elevated RDW values in patients with poor glycemic control and as an early marker for Diabetic nephropathy and cardiovascular complications. 610 patients with type 2 Diabetes Mellitus attending the Diabetic Clinic in Saveetha Medical College were included in a cross-sectional study to compare HbA1c values with RDW values with age and gender. The ratio of patients with poor HbA1c levels: acceptable HbA1c levels of glycemic control was1:4 in the age group 25 years and below. The ratio rose to 1:1 in the 36-45 years age group with a reversal of ratio to 4:1 in patients >65years of age. There was a signi icant correlation between the values of HbA1c with agewith the number of patients increasing with age and showing elevated HbA1c levels. There was no signi icant correlation between the values of RDW and age. There was a signi icant positive correlation between HbA1c and RDW-(p = 0.003, < 0.05 standard). For patients with HbA1c values between 6.2-6-8 %, there was a particularly strong positive correlation with RDW values. In conclusion, there was a signi icant positive correlation between values of RDW and HbA1c, which emphasis that RDW is a good predictive factor for glycemic control.

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Section: Figure 3: Distribution Of the Study Population By Age And Hba1csupporting

confidence: 91%

Correlation of Red Blood Cell Distribution Width (RDW) and Hemoglobin A1C (HbA1c) Levels, In Patients with Type 2 Diabetes Mellitus

Biswas

Chitra

2020

ijrps

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“…Measurements and definitions of smoking, drinking, obesity, and hypertension were as described previously. 3 The eGFR was estimated based on serum creatinine using the equation derived from the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI). 4 The primary outcome was rapid decline in eGFR, which defined as a decline in eGFR of >3 mL/min per 1.73 m 2 per year.…”

Section: Methodsmentioning

confidence: 99%

Neutrophil‐lymphocyte ratio as a predictor of kidney function decline among individuals with diabetes and prediabetes: A 3‐year follow‐up study

Wang

et al. 2019

Journal of Diabetes

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Highlights This study is the first study to confirm that the neutrophil–lymphocyte ratio (NLR) is an independent predictive factor for kidney function decline among individuals with diabetes and prediabetes. Calculating the NLR is easy and inexpensive, so we believe that with more research support the NLR will be used as an effective indicator in the clinical management of individuals with diabetes and prediabetes.

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“…Red blood cell distribution width (RDW) is a hematological parameter, which reflects the heterogeneity of erythro-cyte volume, and it is traditionally used, along with the mean corpuscular volume, to tell the subtypes of anemia [5]. In recent years, several studies had assessed the possible association between RDW and diabetes [6][7][8][9][10][11]. However, studies in diabetic population generated inconsistent results.…”

Section: Introductionmentioning

confidence: 99%

“…One cross-sectional study reported a significantly positive association between RDW and glycated hemoglobin A1c (HbA1c), independent of fasting blood glucose (FBG) levels in nondiabetic American adults [6] while the other reported a negative correlation between RDW and fasting glucose in elderly Chinese [7]. RDW was significantly higher in diabetic patients than healthy subjects and particularly higher in uncontrolled glycemia in a retrospective case-control study [8] while the other one [9] found that type 2 diabetes patients with higher RDW had significantly lower risk of poor glycemic control. The results of cohort studies were also inconsistent [10,11], due to sample size and the level of adjustment.…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Red Blood Cell Distribution Width and Incident Diabetes in Chinese Adults: A Cohort Study

Wang

Zhang

et al. 2020

Journal of Diabetes Research

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Background. Previous studies reported the controvertible association between red blood cell distribution width (RDW) and diabetes. The aim of this study is to explore whether RDW is associated with incident diabetes. Methods. We performed this cohort study in 16,971 Chinese adults (9,956 men and 7,015 women, aged 43.3±12.8 years). The level of RDW was measured at baseline (2014). All the participants were further classified into four quartile groups based on baseline RDW. Fasting blood glucose (FBG) and glycated hemoglobin A1c (HbA1c) were measured annually during follow-up (2014-2019). Diabetes was diagnosed if either FBG≥7.0 mmol/L or HbA1c≥6.5%. We used the Cox proportional hazards regression model to evaluate the association between baseline RDW and incident diabetes. Results. We identified 2,703 new cases of diabetes during five-year follow-up. The incidence was 15.9%. Comparing with participants in the lowest quartile group (reference group), the adjusted hazard ratios (HR) for the risk of diabetes were 1.31 (95% CI: 1.16, 1.48) for the highest quartile group (p trend<0.001), after adjustment for potential confounders. Further adjusting baseline FBG and HbA1c did not materially change the association between RDW and incident diabetes. Each unit increase of RDW was associated with a 16% higher risk of incident diabetes (HR=1.16, 95% CI: 1.06, 1.26) in a fully adjusted model. Sensitivity analysis generated similar results with prospective analyses after excluding aged participants, participants who are overweight and with obesity, participants with elevated blood pressure, participants with decreased eGFR, and those with anemia at baseline. Conclusions. High RDW was associated with high risk of developing diabetes in Chinese adults. As RDW is an inexpensive, noninvasive, and convenient indicator, RDW might be considered for inclusion in the risk assessment of high-risk groups of diabetes.

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Red blood cell distribution width and the risk of being in poor glycemic control among patients with established type 2 diabetes

Cited by 24 publications

References 40 publications

Correlation of Red Blood Cell Distribution Width (RDW) and Hemoglobin A1C (HbA1c) Levels, In Patients with Type 2 Diabetes Mellitus

Correlation of Red Blood Cell Distribution Width (RDW) and Hemoglobin A1C (HbA1c) Levels, In Patients with Type 2 Diabetes Mellitus

Neutrophil‐lymphocyte ratio as a predictor of kidney function decline among individuals with diabetes and prediabetes: A 3‐year follow‐up study

The Relationship between Red Blood Cell Distribution Width and Incident Diabetes in Chinese Adults: A Cohort Study

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