Neutrophil‐lymphocyte ratio as a predictor of kidney function decline among individuals with diabetes and prediabetes: A 3‐year follow‐up study

Li, Jia; Li, Tong; Wang, Haibin; Yan, Wenhua; Mu, Yiming

doi:10.1111/1753-0407.12903

Cited by 4 publications

(3 citation statements)

References 8 publications

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“…A cross-sectional study observed a positive association between a higher NLR and the occurrence of both nephropathy and retinopathy in an Indian population ( 12 ). Additionally, an elevated NLR was correlated with diabetic nephropathy in other studies ( 10 , 28 ) and even served as an independent predictor of kidney function decline in individuals with DM ( 29 ). DR and nephropathy share common underlying mechanisms and often co-occur ( 30 ).…”

Section: Discussionmentioning

confidence: 62%

Association between neutrophil-to-lymphocyte ratio and diabetic retinopathy in patients with type 2 diabetes: a cohort study

Tang,

Li,

2024

Front. Endocrinol.

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BackgroundChronic inflammation is implicated in the development of diabetic retinopathy (DR). The neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation that has been linked to cardiovascular and diabetic kidney diseases. However, the link between NLR and DR remains unclear. As such, this study investigated the association between NLR and DR in Chinese patients.MethodA total of 857 adults diagnosed with type 2 diabetes mellitus (T2DM) without DR at baseline between 2018 and 2021, from a single center in Ningbo, China, were included. Baseline clinical data, including age, sex, T2DM duration, hypertension, smoking, drinking, glycated hemoglobin level, lipid profile, renal function, and NLR, were recorded and analyzed. Cox proportional hazard regression analysis was used to assess the association between NLR and the risk for incident DR.ResultsDuring a median follow-up of 3.0 years, 140 patients developed DR. The multivariable-adjusted hazard ratio (HR) for incident DR across ascending NLR quartiles (≤1.46 [reference], 1.47–1.90, 1.91–2.45 and > 2.45) were 1.000, 1.327 (95% confidence interval [CI] 0.754–2.334), 1.555 (95% CI 0.913–2.648) and 2.217 (95% CI 1.348–3.649), respectively. For each 1-standard deviation increase in NLR, the risk for DR increased by 29.2% (HR 1.292 [95% CI 1.112–1.501) after adjusting for confounding factors.ConclusionResults revealed that a higher NLR at baseline was associated with an increased risk for incident DR. NLR has the potential to be an inexpensive, reliable, and valuable clinical measure that merits further exploration in future studies.

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Section: Discussionmentioning

confidence: 62%

Association between neutrophil-to-lymphocyte ratio and diabetic retinopathy in patients with type 2 diabetes: a cohort study

Tang,

Li,

2024

Front. Endocrinol.

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“…AKI results from a complex interaction between hemodynamic, toxic and inflammatory factors[ 32 ]. Long-term follow-up showed that NLR was an independent predictor of kidney function decline among individuals with diabetes and prediabetes[ 33 , 34 ]. The elevation of NLR immediately after cardiac surgery and on postoperative day 1 was associated with an increased risk of postoperative AKI and 1-year mortality; NLR could assist with the risk stratification of AKI and mortality in high-risk surgical patients[ 7 , 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Association between neutrophil-to-lymphocyte ratio and major postoperative complications after carotid endarterectomy: A retrospective cohort study

Yu¹,

Cui²,

Cheng³

et al. 2021

WJCC

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BACKGROUND Carotid artery cross-clamping during carotid endarterectomy (CEA) may damage local cerebral perfusion and induce cerebral ischemia–reperfusion injury to activate local inflammatory responses. Neutrophil-to-lymphocyte ratio (NLR) is an indicator that reflects systemic inflammation. However, the correlation between NLR and complications after CEA remains unclear. AIM To investigate the association between NLR and major complications after surgery in patients undergoing CEA. METHODS This retrospective cohort study included patients who received CEA between January 2016 and July 2018 at Beijing Tiantan Hospital. Neutrophil and lymphocyte counts in whole blood within 24 h after CEA were collected. The primary outcome was the composite of major postoperative complications including neurological, pulmonary, cardiovascular and acute kidney injuries. The secondary outcomes included infections, fever, deep venous thrombosis, length of hospitalization and cost of hospitalization. Statistical analyses were performed using EmpowerStats software and R software. RESULTS A total of 224 patients who received CEA were screened for review and 206 were included in the statistical analyses; of whom, 40 (19.42%) developed major postoperative complications. NLR within 24 h after CEA was significantly correlated with major postoperative complications ( P = 0.026). After confounding factors were adjusted, the odds ratio was 1.15 (95%CI: 1.03–1.29, P = 0.014). The incidence of major postoperative complications in the high NLR group was 8.47 times that in the low NLR group ( P = 0.002). CONCLUSION NLR is associated with major postoperative complications in patients undergoing CEA.

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“…En este sentido, se han propuesto varios marcadores biológicos que podrían indicar la gravedad de estos procesos inflamatorios. En los últimos años, el INL se ha sugerido como un indicador de inflamación subclínica y demostró ser un buen factor pronóstico para el desarrollo de complicaciones vasculares asociadas a la DM [11][12][13] . En este estudio, se evaluó el INL en una población ecuatoriana con DM2 y se encontró un incremento significativo en este marcador con respecto a los controles.…”

Section: Discussionunclassified

Elevación del índice neutrófilo/linfocito y su relación con la proteína C reactiva en pacientes con diabetes mellitus tipo 2

Santana

Mosquera-Sulbarán

Robalino³

et al. 2021

Rev. Soc. Argent. Diabetes

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La diabetes mellitus (DM) es una enfermedad metabólica caracterizada por hiperglucemia, la cual ocurre como consecuencia de defectos en la acción de la insulina sobre su receptor, en la secreción de insulina o en ambas. La hiperglucemia crónica se asocia con daño, disfunción e insuficiencia a largo plazo de diferentes órganos, especialmente ojos, riñones, nervios, corazón y vasos sanguíneos. Es una enfermedad que ha alcanzado proporciones epidémicas. La última edición del Atlas de la Federación Internacional de Diabetes (FID) muestra que 463 millones de adultos viven actualmente con DM y se estima que habrá 578 millones de adultos con DM para el año 2030 y 700 millones para 2045. La prevalencia de DM (en adultos de 20-79 años) en América Central y América del Sur fue de 8,5% en 2019 y se prevé que para 2030 será de 9,5 y de 9,9% para el año 2045.

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Neutrophil‐lymphocyte ratio as a predictor of kidney function decline among individuals with diabetes and prediabetes: A 3‐year follow‐up study

Cited by 4 publications

References 8 publications

Association between neutrophil-to-lymphocyte ratio and diabetic retinopathy in patients with type 2 diabetes: a cohort study

Association between neutrophil-to-lymphocyte ratio and diabetic retinopathy in patients with type 2 diabetes: a cohort study

Association between neutrophil-to-lymphocyte ratio and major postoperative complications after carotid endarterectomy: A retrospective cohort study

Elevación del índice neutrófilo/linfocito y su relación con la proteína C reactiva en pacientes con diabetes mellitus tipo 2

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