Red Blood Cell Parameters of Healthy Centenarians.

Nozaki, Hiroyuki; Ashitomi, Ikuya; Higa, Kaori; Akisaka, Masafumi

doi:10.3143/geriatrics.32.471

Cited by 4 publications

(2 citation statements)

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“…Moreover, when the frequency rate of the DR types were compared with the parents' death age, that of DR9 decreased as the age of death increased. It was suggested that some loci of HLA-DR relate to longevity and some genetic protection against immunorelated diseases contributes to long-lived lineage [4,126].…”

Section: B Study Of Okinawan Centenariansmentioning

confidence: 99%

Data Resources for Biodemographic Studies on Familial Clustering of Human Longevity

Gavrilova¹,

Gavrilov²

1999

DemRes

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The main cause that hampered many previous biodemographic studies of human longevity is the lack of appropriate data. At the same time, many existing data resources (millions of genealogical records) are under-utilized, because their very existence is not widely known, let alone the quality and scientific value of these data sets are not yet validated. The purpose of this work is to review the data resources that could be used in familial studies of human longevity. This is an extended and supplemented version of the previous study made by the authors upon the request of the National Institute on Aging (1998 NIH Professional Service Contract). The review describes: (1) data resources developed for biodemographic studies, (2) data collected in the projects on historical demography, (3) data resources for long lived individuals and their families, (4) publicly available computerized genealogical data resources, (5) published genealogical and family history data. The review also contains the description of databases developed by the participants of the Research Workshops "Genes, Genealogies, and Longevity" organized by the Max Planck Institute for Demographic Research.

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Section: B Study Of Okinawan Centenariansmentioning

confidence: 99%

Data Resources for Biodemographic Studies on Familial Clustering of Human Longevity

Gavrilova¹,

Gavrilov²

1999

DemRes

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“…Since mature red blood cells do not have nuclei, they are unable to replenish proteins or repair cellular damage. Therefore, they can survive in the circulation for about 100-120 days and then after covering roughly 240 km of their journey through the vasculature, they must be phagocytized by macrophages in the liver and spleen; the average daily rate of loss of RBCs is 2.08 × 10 11 (Nozaki et al 1995;Dean 2005;Adamson 2008;Bosman et al 2008;Huang et al 2011;Jelkmann 2012). In the case of some chronic diseases, including sickle-cell disease, spherocytic anemia, thalassemia, chronic renal failure, and hypersplenism, the lifespan of these cells can be markedly reduced.…”

Section: Introductionmentioning

confidence: 99%

Association between body size and selected hematological parameters in men and women aged 45 and above from a hospitalized population of older adults: an insight from the Polish Longitudinal Study of Aging (1960–2000)

Chmielewski

Strzelec

Chmielowiec

et al. 2017

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In elderly people, anemia occurs with increasing frequency with each advancing decade and can be a harbinger of very serious health conditions, including gastrointestinal bleeding, gastric and duodenal ulcers, and cancer. Therefore, age-dependant changes in hematological parameters deserve special attention. Nonetheless, very few longitudinal studies of aging have focused on possible associations between basic anthropometric characteristics and hematological parameters in older people. Here, we present some evidence that body size can be associated with red blood cell count as well as some other selected hematological parameters in adults aged 45 to 70 years. Longitudinal data on anthropometric and hematological parameters have been obtained from physically healthy residents at the Regional Psychiatric Hospital for People with Mental Disorders in Cibórz, Lubuskie Province, Poland (142 individuals, including 68 men and 74 women). The residents who took psychoactive drugs were excluded from the study. To evaluate the studied relationships, three anthropometric traits were used and three dichotomous divisions of the study sample were made. The medians of body height, body weight, and body mass index at the age of 45 years were used to divide the sample into: shorter and taller, lighter and heavier, and slimmer and stouter individuals, respectively. Student's t-test, Pearson's correlation, and regression analysis were employed. The results of the present study suggest that the relationship between body size and red blood cell count is slightly more pronounced in men and its strength depends on age. However, the correlations between body size and red blood cell count proved to be weak in both sexes. With aging, the strength of the relation decreased gradually, which might have been caused by the aging-associated changes in the hematopoietic system, anemia, or was an artifact. Further studies are needed to elucidate the unclear association between body size and hematological parameters in older adults.

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Okinawa Centenarian Study: Investigating Healthy Aging among the World’s Longest-Lived People

Willcox¹,

Willcox²

2016

Encyclopedia of Geropsychology

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Red Blood Cell Parameters of Healthy Centenarians.

Cited by 4 publications

References 0 publications

Data Resources for Biodemographic Studies on Familial Clustering of Human Longevity

Data Resources for Biodemographic Studies on Familial Clustering of Human Longevity

Association between body size and selected hematological parameters in men and women aged 45 and above from a hospitalized population of older adults: an insight from the Polish Longitudinal Study of Aging (1960–2000)

Okinawa Centenarian Study: Investigating Healthy Aging among the World’s Longest-Lived People

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