Red cell distribution width predicts time to recurrence in patients with primary non–muscle-invasive bladder cancer and improves the accuracy of the EORTC scoring system

Fukuokaya, Wataru; Kimura, Takahiro; Miki, Jun; Kimura, Shoji; Watanabe, H; Fan, Bo; Okada, Daigo; Aikawa, Koichi; Ochi, Atsuhiko; Suzuki, Koichiro; Shiga, Naoki; Abe, Hirokazu; Egawa, Shin

doi:10.1016/j.urolonc.2020.01.016

Cited by 4 publications

(4 citation statements)

References 29 publications

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“…RDW is closely related to various inflammatory cytokines, including interleukin-6 (IL-6), sTNF-RI, CRP, and ESP. Increased RDW levels may indicate an increase in systemic inflammation [ 7 , 19 , 20 ]. A meta-analysis involving 4267 patients suggested that the higher the RDW, the worse the OS, PFS, DFS, and CSS of tumour patients [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

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Novel Blood Indicators of Progression and Prognosis in Renal Cell Carcinoma: Red Cell Distribution Width-to-Lymphocyte Ratio and Albumin-to-Fibrinogen Ratio

Liu²,

et al. 2020

Journal of Oncology

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Objective. To evaluate the value of preoperative red cell distribution width-to-lymphocyte ratio (RLR) and albumin-to-fibrinogen ratio (AFR) to the prognosis of patients after renal cell carcinoma (RCC). Methods. From 2012 to 2016, a total of 273 RCC patients underwent radical nephrectomy or partial nephrectomy. This study retrospectively analyzed this group of patients. X-tile software was used to determine the optimal values of RLR and AFR in the peripheral blood. The nomogram constructed with independent factors was used to predict the survival outcome of the patients after RCC. Results. The RLR of the RCC group was higher than that of the normal control group ( P = 0.002 ), whereas the AFR of the RCC group was lower than that of the normal control group ( P < 0.001 ). RLR and AFR are related to tumour type and tumour-node-metastasis (TNM) stage ( P < 0.05 for all). Cox regression analysis showed that the independent prognostic factors affecting overall survival and disease-free survival in the RCC group were symptom, tumour type, TNM stage, Fuhrman grade, RLR, and AFR ( P < 0.05 for all). The nomogram constructed by multiple factors has better predictive power for patients after RCC. Conclusion. Preoperative RLR and AFR can serve as potential biomarkers to predict the prognosis of postoperative RCC patients and improve the predictability of patient recurrence and survival.

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Section: Discussionmentioning

confidence: 99%

“…Red blood cell distribution width (RDW) reflects the size variability of red blood cells and is routinely measured for anaemia or blood disease. The prognostic role of RDW in several solid tumours has been observed [ 6 , 7 ]. Elevated levels of RDW may reflect systemic inflammation supporting tumour progression.…”

Section: Introductionmentioning

confidence: 99%

Novel Blood Indicators of Progression and Prognosis in Renal Cell Carcinoma: Red Cell Distribution Width-to-Lymphocyte Ratio and Albumin-to-Fibrinogen Ratio

Liu²,

et al. 2020

Journal of Oncology

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“…However, previous studies have reported that this risk scoring model has suboptimal discriminatory power to predict IVR in patients with NMIBC. 4 , 6 Xylinas et al retrospectively assessed the discrimination of the EORTC risk model in 4689 patients with NMIBC but found a poor discrimination performance for IVR (c-index = 0.597). 6 This risk scoring system does not consider the biological background of individual tumors.…”

Section: Discussionmentioning

confidence: 99%

“… 2 Although the EORTC risk scoring system is a well-established and valuable tool to predict IVR, the accuracy of this scoring system could be improved. 4 , 5 Xylinas et al retrospectively evaluated 4689 patients with NMIBC and found that the EORTC risk scoring model exhibits poor discrimination performance for IVR (c-index = 0.597). 6 This scoring system relies entirely on tumor characteristics and ignores the tumor biology in individual patients.…”

Section: Introductionmentioning

confidence: 99%

Expression of L-Type Amino Acid Transporter 1 is a Predictive Biomarker of Intravesical Recurrence in Patients with Non-Muscle Invasive Bladder Cancer

Sawazaki¹,

Ito²,

Sato³

et al. 2021

RRU

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The impact of smoking on recurrence and progression of non-muscle invasive bladder cancer: a systematic review and meta-analysis

Ślusarczyk

Zapała

et al. 2022

J Cancer Res Clin Oncol

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Objectives Although smoking is a well-recognized causative factor of urothelial bladder cancer and accounts for 50% of cases, less is known about the prognostic significance of smoking on non-muscle invasive bladder cancer (NMIBC) prognosis. This systematic review and meta-analysis aimed to evaluate the effect of smoking on the risk of NMIBC recurrence and progression. Materials and methods We systematically searched Medline, Web of Science and Scopus databases for original articles published before October 2021 regarding the effect of smoking on NMIBC recurrence and progression. Information about smoking status and the number of events or odds ratio or hazard ratio for event-free survival must have been reported to include the study in the analysis. Quality In Prognosis Studies tool was utilized for the risk of bias assessment. Results We selected 64 eligible studies, including 28 617 patients with NMIBC with available data on smoking status. In a meta-analysis of 28 studies with 7885 patients, we found that smokers (current/former) were at higher risk for recurrence (OR = 1.68; 95% CI 1.34–2.09; P < 0.0001) compared to never smokers. Subgroup analysis of 2967 patients revealed that current smokers were at a 1.24 higher risk of recurrence (OR = 1.24; 95% CI 1.02–1.50; P = 0.03) compared to former smokers. A meta-analysis of the hazard ratio revealed that smokers are at higher risk of recurrence (HR = 1.31; 95%CI 1.15–1.48; P < 0.0001) and progression (HR = 1.18; 95%CI 1.08–1.29; P < 0.001) compared to never smokers. Detrimental prognostic effect of smoking on progression, but not for recurrence risk was also noted in the subgroup analysis of high-risk patients (HR = 1.30; 95%CI 1.09–1.55; P = 0.004) and BCG-treated ones (HR = 1.15; 95%CI 1.06–1.25; P < 0.001). Conclusion In conclusion, patients with non-muscle invasive bladder cancer and a history of smoking have a worse prognosis regarding recurrence-free and progression-free survival compared to non-smokers.

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Red cell distribution width predicts time to recurrence in patients with primary non–muscle-invasive bladder cancer and improves the accuracy of the EORTC scoring system

Cited by 4 publications

References 29 publications

Novel Blood Indicators of Progression and Prognosis in Renal Cell Carcinoma: Red Cell Distribution Width-to-Lymphocyte Ratio and Albumin-to-Fibrinogen Ratio

Novel Blood Indicators of Progression and Prognosis in Renal Cell Carcinoma: Red Cell Distribution Width-to-Lymphocyte Ratio and Albumin-to-Fibrinogen Ratio

Expression of L-Type Amino Acid Transporter 1 is a Predictive Biomarker of Intravesical Recurrence in Patients with Non-Muscle Invasive Bladder Cancer

The impact of smoking on recurrence and progression of non-muscle invasive bladder cancer: a systematic review and meta-analysis

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