Red Cell Indices and Functions Differentiating Patients with the β-Thalassaemia Trait from those with Iron Deficiency Anaemia

Okan, Vahap; Çiğiloğlu, Ahmet; Cifci, Sami; Yılmaz, Mehmet; Pehlıvan, Mustafa

doi:10.1177/147323000903700103

Cited by 39 publications

(27 citation statements)

References 12 publications

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“…in their study proved S and L as the best discrimination index with highest YI. [28] Similarly, Yeo et al . reported a 38.7% increase in accuracy and 31.1% decrease in confirmatory testing among pregnant patients.…”

Section: Discussionmentioning

confidence: 98%

The role of discriminant functions in screening beta thalassemia trait and iron deficiency anemia among laboratory samples

et al. 2017

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INTRODUCTION:Most important differential diagnosis for microcytosis and hypochromia is beta thalassemia trait (BTT) and iron deficiency anemia.AIM:To study the utility of discriminant functions (DFs) and red cell indices in distinguishing BTT and iron deficiency anemia.METHODS:The study is observational (cross sectional). A total of 350 patients, 43 BTT, and 307 iron-deficiency anemia reflecting actual disease prevalence were included. Their complete red blood cell parameters, hemoglobin A2, and serum ferritin level wherever required were obtained. Receiver operator characteristic curve was drawn for each DF and results compared with other studies.RESULTS:Among the six DFs, the highest sensitivity (97.7%) and specificity (98.6%) was shown, respectively, by Shine and Lal (S and L) and England and Fraser index (E and F) in identifying cases of BTT. Youden index of the Mentzer index (MI) was the highest (69.0) and S and L, the lowest (13.2) indicating MI to be the most efficient and the S and L, the least in differentiating the two entities. Red cell distribution width index (RDWI) showed the highest accuracy (91.6%), whereas S and L showed the least accuracy (29.6%).CONCLUSION:MI was the most efficient in discriminating BTT from iron deficiency anemia (IDA). RDWI stands to be the most accurate. S and L could at best be used as screening tool rather than DF. No study except one agreed with us because convenient sampling used in other studies generated bias in their results. Statistically, this study bears far more relevance than other studies because the sample distribution reflects the prevalence of IDA and BTT in the community.

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Section: Discussionmentioning

confidence: 98%

The role of discriminant functions in screening beta thalassemia trait and iron deficiency anemia among laboratory samples

et al. 2017

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“…8 Keikhaei B et al, According to Youden's index (YI), Discriminating Functions in the order of highest to lowest were KI >G and KI > RDWI >E and FI >RBC>M I>EI >TI >SI >S and BI >RI>S and LI >B and FI. 12 Mussarrat et al, found RDWI is leading. 9 TP, SA et al Youden's index in decreasing order was as follows: RDW-SD > RBC COUNT> E and F >MI >RI >RDWI >G and K >SI >S and L >RDWCV.…”

Section: Discussionmentioning

confidence: 99%

“…7 Okan V et al studied the S and L and G and K indices were the best indicators in both comparisons and the RDW index was the worst. 12 Demir et al found the most accurate discriminative index for patients younger than 10 years was Shine and Lal and for those older than 10 years it was RDW index. 8 Keikhaei B et al, According to Youden's index (YI), Discriminating Functions in the order of highest to lowest were KI >G and KI > RDWI >E and FI >RBC>M I>EI >TI >SI >S and BI >RI>S and LI >B and FI.…”

Section: Discussionmentioning

confidence: 99%

Study of blood indices and high performance liquid chromatography (HPLC) in differentiation of β-thalassemia trait and iron deficiency anaemia

2017

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Background: Iron deficiency anemia (IDA) and beta thalassaemia trait (BTT) are two of the most common causes of microcytic anemia.It is essential to differentiate between the two, so as to avoid unnecessary iron therapy which is contraindicated in beta thalassaemia .We retrospectively evaluated the reliability of various indices for differential diagnosis of microcytosis and 𝛽-TT in the same patient groups .Methods: A total of 200 patients were evaluated. We calculated 6 discrimination indices in all patients with anemia or suspected beta thalassemia. None of the subjects had combined IDA and 𝛽-TT. The patient groups were evaluated according to the Mentzer, Shine and Lal, England and Fraser,Srivastava, Green and King, Ricerca.Results: According to percentage correctly diagnosed criteria, Ricerca and Mentzer index are considered as the two best discrimination indices in differentiation between β thalassemia trait and iron deficiency anaemia .Youden’s index showed the following ranking with respect to the indices’ ability to distinguish between 𝛽-TT and IDA, Ricerca index > Mentzer index > Green and King index > Srivastava index > Shine and Lal index > England and Fraser index.Conclusions: Ricerca and Mentzer index are considered as the two best discrimination indices in differentiation between β thalassemia trait and iron deficiency anaemia.Keywords: Iron deficiency anemia (IDA) and beta thalassaemia trait (𝛽-TT)

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“…Patients who fulfilled the inclusion and the exclusion criteria were selected from the hematology out-patient clinic. Diagnosis of BTM was made in the case of hypochromic and microcytic hemoglobins, normal serum ferritin levels, and elevated serum levels of HbA2 (>4.0%) [26]. Hb electrophoresis was performed using Helena gel electrophoresis Beckmann densitometry.…”

Section: Study Populationmentioning

confidence: 99%

Coronary Microvascular function, Peripheral Endothelial Function and Carotid IMT in beta-thalassemia minor

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et al. 2013

Thrombosis Research

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Red Cell Indices and Functions Differentiating Patients with the β-Thalassaemia Trait from those with Iron Deficiency Anaemia

Abstract: This study examined the diagnostic accuracy of nine indices to discriminate between patients with mild-to-moderate (haemoglobin 8.5 -11 g/dl) or moderateto-severe (haemoglobin < 8.

Cited by 39 publications

References 12 publications

The role of discriminant functions in screening beta thalassemia trait and iron deficiency anemia among laboratory samples

The role of discriminant functions in screening beta thalassemia trait and iron deficiency anemia among laboratory samples

Study of blood indices and high performance liquid chromatography (HPLC) in differentiation of β-thalassemia trait and iron deficiency anaemia

Coronary Microvascular function, Peripheral Endothelial Function and Carotid IMT in beta-thalassemia minor

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