AimOutbreaks have a wide spectrum of psychosocial impact on individuals. This study aimed to investigate the psychosocial effects of measures to prevent the spread of the novel coronavirus disease on older adults in Turkey.MethodsA survey was conducted of 104 adults who had to stay at home during the pandemic. Participants’ depressive symptoms, anxiety symptoms, nutritional status, health‐related quality of life, and sleep quality were assessed.ResultsThe frequency of depressive and anxiety symptoms was 37.5% and 29.8%, respectively. The frequency of depressive symptoms was higher in women, individuals age ≥85 years, and those with less education and low monthly income. Anxiety symptom frequency was also higher in women and those with less education and low monthly income. Quality of life and sleep were worse in those with depressive symptoms and anxiety symptoms.ConclusionTo our knowledge, this is the first published study to investigate the effect of a pandemic on the mood, anxiety symptoms, nutrition status, quality of life, and sleep of older adults during the pandemic period. Our findings indicate the importance of psychosocial support in older individuals during and after the pandemic period.

This study examined the diagnostic accuracy of nine indices to discriminate between patients with mild-to-moderate (haemoglobin 8.5 -11 g/dl) or moderateto-severe (haemoglobin < 8.

Glioblastoma multiforme (GBM) is the most common and the most aggressive primary malignant tumor of the brain. Prognostic factors in GBM can be sorted as age, tumor localization, tumor diameter, symptom period and type, the extent of surgery, postoperative tumor volume, and adjuvant radiotherapy and/or chemotherapy status. Besides the interactions between actin microfilaments, microtubules, and intermediate filaments, environmental factors and intracellular signals which regulate them affect the cell invasion. Rho proteins and therefore Rho-kinase activation play important role at these changes. The aim of this study is to evaluate the relationship between the Rho-kinase pathway gene expressions and prognosis in GBM. Ninety-eight patients diagnosed as GBM between 2001 and 2010 were enrolled into the study. RNA was obtained from the paraffinized tumor tissue of the patients with formalin-fixed, paraffin-embedded RNA isolation kit and the mRNA expressions of 26 genes were investigated. There was a statistically significant negative correlation between the ages at the diagnosis and survival. There was a significant relationship between the overexpression of Rho-kinase pathway-related genes LIMK1, CFL1, CFL2, and BCL2 and low expression of MAPK1 gene and the survival of the patients. These results demonstrate for the first time that there is a marked contribution of Rho-kinase pathway-related genes to the progression and survival of the GBM. The expression of these genes may be related to response of multimodal therapy or these parameters could be used to determine possible unresponsive patients before treatment.

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