Red or white wine consumption effect on atherosclerosis in healthy individuals (In Vino Veritas study)

Táborský, Miloš; Ošťádal, Petr; Adam, Tomáš; Moravec, O; Gloger, V; Schee, Alexandr; Skala, T

doi:10.4149/bll_2017_072

Cited by 18 publications

(14 citation statements)

References 18 publications

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“…In contrast to the results of our study, grape products containing polyphenols had no significant effect on CRP either in people with type 2 diabetes (63,71,82) , chronic kidney disease (59,113) , haemodialysis (70,114,115) , hypertension (66,68,116) , obesity (62,67) , overweight (117) , the MetS (118) , smoking habit (61) , high risk for CVD (119) and CVD (65,120,121) or in healthy participants (30,57,60,64,69,(72)(73)(74)(122)(123)(124)(125)(126)(127)(128)(129)(130) . Some of these studies were only investigated in our systematic review and were not included in our meta-analysis because they did not meet our inclusion criteria (30,(47)(48)(49)(50)(52)(53)(54)(55)…”

Section: Discussioncontrasting

confidence: 99%

The effect of grape products containing polyphenols on C-reactive protein levels: a systematic review and meta-analysis of randomised controlled trials

Sarkhosh-Khorasani

Hosseinzadeh

2020

Br J Nutr

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Although grape polyphenols can decrease chronic inflammations, their effect on C-reactive protein (CRP) levels is still controversial. So, this meta-analysis was conducted to investigate the effect of grape products containing polyphenols on CRP concentrations. In order to collect the relevant randomized controlled trials (RCTs), the data bases of PubMed, Scopus, Web of Science, and Google Scholar were searched up to March 30, 2020. The random-effects model, standardized mean difference, and 95% confidence interval were applied in data analysis. Meta-analysis was conducted over 17 eligible RCTs containing a total of 668 participants. The study registration number is CRD42018110169. Based on the results, grape products containing polyphenol decreased the CRP levels significantly (SMD = -0.229; 95% CI: -0.41, -0.05; P = 0.013). The sensitivity analysis was performed by removing each individual study and the results did not change. According to the subgroup analysis, higher doses of grape polyphenols (˃ 500 mg/d) and longer intervention periods (≥ 12 wk) had significant effects on CRP levels. Furthermore, grape polyphenols significantly reduced the CRP levels in patients with a clinical condition. In the same vein, grape seed extract and other grape products, such as grape extract, juice, and raisin, decreased the CRP levels significantly. According to the meta-regression results, the CRP level depends on the dose and duration of the grape polyphenols supplementation. Based on the findings, grape products containing polyphenols had a significant effect on CRP levels. Further well-designed and long-term clinical trials are highly recommended to achieve more comprehensive and accurate results.

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Section: Discussioncontrasting

confidence: 99%

The effect of grape products containing polyphenols on C-reactive protein levels: a systematic review and meta-analysis of randomised controlled trials

Sarkhosh-Khorasani

Hosseinzadeh

2020

Br J Nutr

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“…After 12 months, LDL was similarly decreased in both groups, while total cholesterol was lowered in the red wine group, but the levels did not differ from the white wine group. In general this study failed to show positive clinical differences in atherosclerosis markers in healthy participants [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

“…Red and white wine lowered postprandial triglyceride concentrations [ 25 ]. In the Vino Veritas randomised trial the effects of red and white wine on atherosclerosis were investigated [ 26 ]. In this study, 157 healthy participants were randomised to receive either white or red wine for one year.…”

Section: Resultsmentioning

confidence: 99%

Wine: An Aspiring Agent in Promoting Longevity and Preventing Chronic Diseases

et al. 2018

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Introduction: Moderate wine consumption is a characteristic of the Mediterranean diet. Studies around the world have shown a beneficial effect of moderate alcohol intake, especially wine, on health. This review aims to critically summarise the most recent studies that investigate the beneficial effects of moderate wine intake on human health. Methods: The PubMed database was comprehensively searched to identify trials published from 2013 to 2018 that investigated the association between moderate wine consumption and health. Results: The most recent studies confirm the valuable role of moderate wine consumption, especially red wine, in the prevention and treatment of chronic diseases such as cardiovascular disease, metabolic syndrome, cognitive decline, depression, and cancer. In the meantime, recent studies also highlight the beneficial role of red wine against oxidative stress and in favour of desirable gut bacteria. The beneficial role of red wine has been attributed to its phytochemical compounds, as highlighted by clinical trials, where the effect of red wine has been compared to white wine, non-alcoholic wine, other alcoholic drinks, and water. Conclusions: Moderate wine intake, at 1–2 glasses per day as part of the Mediterranean diet, has been positively associated with human health promotion, disease prevention, and disease prognosis.

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“…Triglyceride levels were not significantly altered. The authors could not confirm any clinically important differences in biomarkers of atherosclerosis between the two types of wine, and they attributed this partially to the prospective long-term design of the trial [116].…”

Section: Dyslipidemiamentioning

confidence: 88%

Wine Intake in the Framework of a Mediterranean Diet and Chronic Non-Communicable Diseases: A Short Literature Review of the Last 5 Years

2020

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Dietary habits are a determining factor of the higher incidence and prevalence of chronic non-communicable diseases (NCDs). In the aim to find a possible preventive and intervention strategy, the Mediterranean diet (MedDiet) has been proposed as an effective approach. Within the MedDiet, moderate wine consumption with meals is a positive item in the MedDiet score; however, recent studies have reported a dose-response association between alcohol consumption and higher risk of a large number of NCDs. This review aimed to evaluate the association between NCDs and wine consumption in the framework of the MedDiet, with a simple review of 22 studies of the highest-level literature published over the last five years. We found that the information regarding the effects of wine in different health outcomes has not varied widely over the past five years, finding inconclusive results among the studies evaluated. Most of the literature agrees that light to moderate wine intake seems to have beneficial effects to some extent in NCDs, such as hypertension, cancer, dyslipidemia and dementia, but no definitive recommendations can be made on a specific dose intake that can benefit most diseases.

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Red or white wine consumption effect on atherosclerosis in healthy individuals (In Vino Veritas study)

Cited by 18 publications

References 18 publications

The effect of grape products containing polyphenols on C-reactive protein levels: a systematic review and meta-analysis of randomised controlled trials

The effect of grape products containing polyphenols on C-reactive protein levels: a systematic review and meta-analysis of randomised controlled trials

Wine: An Aspiring Agent in Promoting Longevity and Preventing Chronic Diseases

Wine Intake in the Framework of a Mediterranean Diet and Chronic Non-Communicable Diseases: A Short Literature Review of the Last 5 Years

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