Red wine and green tea reduce <i>H pylori-</i> or <i>VacA-induced</i> gastritis in a mouse model

Ruggiero, Paolo; Rossi, Giacomo; Tombola, Francesco; Pancotto, Laura; Lauretti, Laura; Giudice, Giuseppe Del; Zoratti, Mario

doi:10.3748/wjg.v13.i3.349

Cited by 61 publications

(38 citation statements)

References 32 publications

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“…Oral administration of green tea catechins in combination with sucralfate in Mongolian gerbils infected with H. pylori revealed that the colony-forming units (CFU) of H. pylori was significantly decreased (Takabayashi et al, 2004). In line with these findings, another study revealed that green tea concentrates could influence gastric colonization or gastric pathology in H. pylori-infected or VacA-treated mice (Ruggiero et al, 2007). , 2008).…”

Section: Camellia Sinensismentioning

confidence: 86%

Medicinal plants in the treatment ofHelicobacter pyloriinfections

Safavi

Shams-Ardakani

Foroumadi

2014

Pharmaceutical Biology

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Context: Helicobacter pylori is a small, spiral, Gram-negative bacillus that plays a role in the pathogenesis of a number of diseases ranging from asymptomatic gastritis to gastric cancer. Schedule compliance, antibiotic drug resistance, and side-effects of triple or quadruple therapy have led to research for novel candidates from plants.Objective: The purpose of this paper is to review the most potent medicinal plants of recently published literature with anti-H. pylori activity. For centuries, herbals have been used by traditional healers around the world to treat various gastrointestinal tract disorders such as dyspepsia, gastritis, and peptic ulcer disease. The mechanism of action by which these botanicals exert their therapeutic properties has not been completely and clearly elucidated. Anti-H. pylori properties may be one of the possible mechanisms by which gastroprotective herbs treat gastrointestinal tract disorders. Materials and methods: Electronic databases such as PubMed, Google scholar, EBSCO, and local databases were explored for medicinal plants with anti-H. pylori properties between 1984 and 2013 using key words ''medicinal plants'' and ''Helicobacter pylori'' or ''anti-Helicobacter pylori''. Results: A total of 43 medicinal plant species belonging to 27 families including Amaryllidaceae,

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Section: Camellia Sinensismentioning

confidence: 86%

Medicinal plants in the treatment ofHelicobacter pyloriinfections

Safavi

Shams-Ardakani

Foroumadi

2014

Pharmaceutical Biology

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“…Wine constituents have exhibited antibiotic activity against H. pylori isolates and protected against associated gastric damage in mice (Daroch et al 2001, Mahady et al 2003, Ruggiero et al 2007, Martini et al 2009.…”

Section: Gastrointestinal Effectsmentioning

confidence: 99%

Wine and Health: A Review

Guilford

Pezzuto

2011

Am. J. Enol. Vitic.

168

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Abstract:As indicated by epidemiological studies, regular and moderate wine consumption, particularly red wine, has been associated with health benefits. Clinical studies and work performed with animal models indicate that wine may protect against cardiovascular disease, atherosclerosis, hypertension, certain types of cancer, type 2 diabetes, neurological disorders, and metabolic syndrome. The mechanism of action has been attributed to antioxidant, lipid regulating, and anti-inflammatory effects. A variety of wine constituents have been studied in various disease models. Both the alcoholic and polyphenolic components of wine are believed to contribute to these beneficial effects. As wine is a complex mixture, it is likely that a multitude of chemical constituents, as well as their metabolites, work synergistically to impact human health. In sum, although wine drinking may be contraindicated in certain individuals, in healthy people, regular consumption of moderate amounts of wine may protect against certain chronic health conditions.

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“…The polyphenol compounds may form aggregates with the toxin, in turn preventing its receptor binding and internalization into the host cell (27). A recent finding by Ruggiero et al (19) found that red wine was able to prevent H. pylori-induced gastric epithelium damage in mice, suggesting that VacA inhibition may be involved. However, further studies are needed to determine the specific effect(s) (e.g., loss of attachment mechanisms, virulence factors, host membrane integrity, etc.)…”

mentioning

confidence: 99%

Antibacterial Effects of Grape Extracts onHelicobacter pylori

Brown¹,

Huang²,

Haley‐Zitlin

et al. 2009

Appl Environ Microbiol

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Anti-Helicobacter pylori activities were determined by agar dilution, confocal laser scanning microscopy, and cell proliferation assays following treatment with various grape extracts. Muscadine grape skin possessed the strongest activity, followed by grape synergy (skin and seed) and seed, suggesting that higher phenolic levels do not necessarily determine overall anti-H. pylori efficacy.Helicobacter pylori is considered the etiological agent of peptic ulcers and gastritis and is associated with mucosa-associated lymphoid tissue lymphoma and gastric cancer (4). Although treatment is usually effective, it can result in side effects, such as antibiotic resistance development (14) and relapse due to low compliance (2). Therefore, alternative methods should be explored to treat H. pylori infection.Studies have reported many natural plant extracts with anti-H. pylori activity, including garlic, broccoli, cranberries, and green tea (5,12,16,26). Grapes (Vitis vinifera), well known for their high levels of antioxidants and polyphenols, have also shown promise as novel antimicrobial agents. A few studies have already reported the anti-H. pylori activities of grape seed and wine, including an active chemical constituent (e.g., resveratrol, a stilbene from red wine) (13). However, no effort has been made to evaluate the grape skin or different grape types (e.g., table and muscadine grapes). For example, muscadines (Vitis rotundifolia) contain significantly higher levels of phenolics than commercial table grapes in addition to possessing some unique forms of these compounds (23). However, little is currently known about the antibacterial properties these fruits possess, making them prime candidates for study. In addition, it is believed that the high complexity of bioactive compounds present in these products and their broad range of activity over a number of microorganisms may make it difficult for microbes to acquire resistance during treatment (26).The objectives of this study were to investigate the effects of various grape extracts against H. pylori and to determine any correlations between anti-H. pylori activity and extract phenolic content.Five H. pylori strains (G2-1, 26695, WV 99, NB2-1, and 1324P-1) were obtained from Douglas Berg (Washington University, St. Louis, MO), and five clinical H. pylori isolates (D5251, D5131, D5178, D5136, and D5135) were obtained from Ben Gold (Emory University and Centers for Disease Control and Prevention, Atlanta, GA). H. pylori P1pDH80, a green fluorescent protein (GFP)-labeled strain, was provided by Rainer Haas (Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Munchen, Germany). H. pylori SS1, a mouse-adapted strain, was provided by Kathryn Eaton (Department of Veterinary Biosciences, Ohio State University, Columbus, OH). For the entire study, bacteria were grown on brain heart infusion agar (Difco Laboratories, Detroit, MI) (pH 7.4 Ϯ 0.2) supplemented with 10% horse serum (HS) (Sigma Chemical Co., St. Louis, MO) at 37°C for 72 h under microaerophilic ...

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Red wine and green tea reduce H pylori- or VacA-induced gastritis in a mouse model

Cited by 61 publications

References 32 publications

Medicinal plants in the treatment ofHelicobacter pyloriinfections

Medicinal plants in the treatment ofHelicobacter pyloriinfections

Wine and Health: A Review

Antibacterial Effects of Grape Extracts onHelicobacter pylori

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