Red wine mitigates the postprandial increase of LDL susceptibility to oxidation

Natella, Fausta; Ghiselli, Andrea; Guidi, Alessia; Ursini, Fulvio; Scaccini, Cristina

doi:10.1016/s0891-5849(01)00504-4

Cited by 95 publications

(57 citation statements)

References 62 publications

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“…This concept was popularized as the ''French Paradox'' from the Monitoring of Trends and Determinants in Cardiovascular Disease (MONICA) project in which it was found that the French, whose traditional cardiovascular risk factors are at least as great as those of other Western countries, had a lower cardiovascular risk than the latter societies ( Figure 1). 2 Multiple possible mechanisms have been suggested for this finding, such as actions that favorably affect lipid oxidation, 3 platelet activity, 4 and fibrinolytic activity. 5 It is essential to recognize that the reported benefits of alcohol have been noted predominantly in cohort epidemiological analyses and assessments of isolated effects of alcohol and wine consumption in populations, which leaves them subject to multiple confounding factors.…”

Section: Introductionmentioning

confidence: 91%

Alcohol, Wine, and Cardiovascular Health

Lindberg

Amsterdam

2008

Clinical Cardiology

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Studies evaluating the health benefits of alcohol and wine have demonstrated that moderate consumption is associated with a decrease in all-cause and cardiovascular mortality. Various populations and alcoholic beverages exhibit this effect to different degrees. Alcoholic beverages exhibit multiple mechanisms that may favorably influence cardiac risk potential actions on platelets, antioxidants, fibrinolysis, and lipids. However, other data suggest that the perceived benefit of alcoholic beverages in general, and wine in particular, are the result of socioeconomic confounders. In the absence of more rigorous evidence, it is not currently possible to define the role of wine in human health.

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Section: Introductionmentioning

confidence: 91%

Alcohol, Wine, and Cardiovascular Health

Lindberg

Amsterdam

2008

Clinical Cardiology

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“…These data may contribute to settle the discrepancies in the results obtained from different trials studies (Serafini, Maiani, & Ferro-Luzzi, 1998;Duthie et al, 1998;Fernández-Pachón et al, 2005;Natella et al, 2001). Moreover, these observations indicate that further investigations with a wide number of subjects are needed to better assess the relationship between trend of sex hormones levels during the three phases of the ovarian cycle and variations of the antioxidant status after the consumption of rich-in-antioxidants foods.…”

Section: Resultsmentioning

confidence: 83%

Different Behaviour of Plasma Antioxidant Status after Red Wine Consumption in Subjects of the Same Sex: A Preliminary Report

Giammanco¹,

Majo²,

Leto³

et al. 2012

JFR

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Several studies report that the plasma antioxidant capacity (PAC) increases after a single ingestion of red wine. However, data on the different behaviour of PAC after food intake in subjects of the same sex are still lacking. On the basis of these observations some investigations were undertaken in order to evaluate the effects of red wine intake on PAC in a homogeneous groups of healthy female volunteers (n=18). Additionally, the possible correlation between increase of PAC values and increase in uric acid levels was also assessed. PAC and uric acid concentrations were determined before wine intake and 50, 120 and 240 minutes thereafter. The results obtained following these studied highlighted two different patterns of variation of plasma AC values after red wine intake in women. Group "A" exhibits a significant increase in PAC at 120 minutes after wine consumption while group "B" showed a peak level of AC 50 minutes after wine intake. However, no significant correlation was highlighted between increased levels of uric acid and PAC. These results provide a strong argument for the hypothesis that sampling procedures may be one of the confounding factor in studies on the plasma antioxidant status after food or beverage consumption. These preliminary observations indicate that sex-based selection of volunteers should be considered in further investigations.

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“…While some authors found no change in infl ammatory markers (IL-6, CRP) following acute intake of red wine and beer [Tousoulis et al, 2008], others reported depletion in serum IL-6 levels [Sacanella et al, 2007] and an amplifi cation of IL-10 and reduction of NF-kappaB [Natella et al, 2001] following acute red wine intake. Avogaro et al [2003] observed that moderate red wine intake improved post-glucose free fatty acid profi les but did not modify the plasma concentrations of both TNF- and adiponectin concentrations.…”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, plasma levels of adiponectin, as an insulin-sensitizer, are down-regulated in obese patients [Hung et al, 2008]. Many studies have demonstrated that a moderate red wine consumption decreased the risk and mortality from coronary heart disease [Gaziano et al, 1993; Kerry & Abbey, 1997; Kondo et al, 1994;Natella et al, 2001;Iriti & Vitalini, 2012]. Previously, our data provided evidence for the acute antioxidant effect of red wine, especially the organic types, but there were no statistically signifi cant effects on the LDL-oxidation in humans.…”

Section: Introductionmentioning

confidence: 99%