Red yeast rice extracts suppress adipogenesis by down-regulating adipogenic transcription factors and gene expression in 3T3-L1 cells

Jeon, Tae‐Il; Hwang, Seong Gu; Hirai, Shizuka; Matsui, Tohru; Yano, Hideo; Kawada, Teruo; Lim, Beong Ou; Park, Dong Ki

doi:10.1016/j.lfs.2004.06.012

Cited by 118 publications

(71 citation statements)

References 29 publications

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“…[17][18][19] Recently, Jeon et al demonstrated that water extracts of RMR suppress adipogenesis in 3T3-L1 preadipocytes through the downregulated expression of adipogenic transcription factors and other specific genes. 20 On the basis of these findings, we suggest that RMR could decrease the adipose tissue mass and might alleviate the progression of obesity.…”

Section: Introductionmentioning

confidence: 76%

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Red mold rice prevents the development of obesity, dyslipidemia and hyperinsulinemia induced by high-fat diet

Chen

Lee

et al. 2008

Int J Obes

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Objective: To investigate the influences of red mold rice (RMR) on obesity and related metabolic abnormalities. Methods and results:The 3T3-L1 cell line was used to examine the effects of RMR extracts on preadipocytes and on mature adipocytes. Both water and ethanol extracts of RMR had inhibitory effects on 3T3-L1 preadipocyte proliferation and differentiation. Water extracts of RMR enhanced the lipolysis activity in mature adipocytes, which negatively correlated with the triglyceride content within cells. RMR treatment did not affect heparin-releasable lipoprotein lipase activity in mature adipocytes. Furthermore, animal studies were carried out to explore the antiobesity effects of RMR. The control group of male Wistar rats were fed regular laboratory feed, whereas the other groups were fed the high-fat (HF) diet supplemented with lovastatin, rice or RMR (0.4 and 2%, w w À1 ). The relative caloric intakes of the control and HF groups were 3.34 and 4.85 kcal g À1 , respectively. After 6 weeks, rats treated with RMR at the 0.4 and 2% doses had lower weight gain and less fat pads mass accompanied with smaller fat cells than did the HF-diet rats. These effects probably resulted from an increase in the lipolysis activity of adipose tissue and a reduction in food/energy consumption. On the other hand, the RMR supplement significantly reduced serum total cholesterol, serum low-density lipoprotein (LDL) cholesterol, the ratio of LDL to high-density lipoprotein (HDL) cholesterol and serum insulin in the HF group. Moreover, the 2% RMR treatment significantly increased serum HDL cholesterol. Conclusion: This study reveals for the first time that RMR can prevent body fat accumulation and improve dyslipidemia. The antiobesity effects of RMR mainly derive from the lipolytic activity and mild antiappetite potency of RMR. In addition, extracts of RMR suppressed the proliferation and differentiation in 3T3-L1 preadipocytes, which might have contributed to the inhibition of new adipocyte formation or hyperplasia in adipose tissue.

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Section: Introductionmentioning

confidence: 76%

“…Jeon et al 20 added 50 mg ml À1 lovastatin to 3T3-L1 preadipocytes to clarify the antiadipogenic ingredients of RMR extracts, however; lovastatin showed a marginal influence on adipogenesis at this dose. More studies are required to examine the effects of lovastatin on 3T3-L1 differentiation.…”

Section: Discussionmentioning

confidence: 99%

Red mold rice prevents the development of obesity, dyslipidemia and hyperinsulinemia induced by high-fat diet

Chen

Lee

et al. 2008

Int J Obes

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“…These results indicate that fucoxanthin and fucoxanthinol suppress the differentiation of preadipocytes to adipocytes in 3T3-L1 cells and their suppressive effect is, at least, one mechanism underlying the anti-obesity effect of dietary fucoxanthin. Some other natural compounds and extracts, including catechin (28), sterols (29), tannic acid (30), phenolic lipids (31) and red yeast rice extracts (32), also inhibit 3T3-L1 differentiation. Retinoids also inhibit the early stage of differentiation of 3T3-L1 cells (33).…”

Section: Discussionmentioning

confidence: 99%

Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells

Maeda

Hosokawa²,

Sashima³

et al. 2006

Int J Mol Med

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130

145

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Abstract. Fucoxanthin is a major carotenoid found in edible seaweed such as Undaria pinnatifida and Hijikia fusiformis. We investigated the suppressive effects of fucoxanthin and its metabolite, fucoxanthinol, on the differentiation of 3T3-L1 preadipocytes to adipocytes. Fucoxanthin inhibited intercellular lipid accumulation during adipocyte differentiation of 3T3-L1 cells. Furthermore, fucoxanthin was converted to fucoxanthinol in 3T3-L1 cells. Fucoxanthinol also exhibited suppressive effects on lipid accumulation and decreased glycerol-3-phosphate dehydrogenase activity, an indicator of adipocyte differentiation. The suppressive effect of fucoxanthinol was stronger than that of fucoxanthin. In addition, in 3T3-L1 cells treated with fucoxanthin and fucoxanthinol, peroxisome proliferator-activated receptor Á (PPARÁ), which regulates adipogenic gene expression, was down-regulated in a dosedependent manner. These results suggest that fucoxanthin and fucoxanthinol inhibit the adipocyte differentiation of 3T3-L1 cells through down-regulation of PPARÁ. Fucoxanthinol had stronger suppressive effects than fucoxanthin on adipocyte differentiation in 3T3-L1 cells.

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“…Complementary DNA was synthesized using Revertaid™ First Strand Synthesis Kit with oligo (dT) 18 primers and RevertAid™ reverse transcriptase (Fermentas). The synthesis reaction was performed on GeneAmp PCR System 9700 (Applied Biosystems).…”

Section: Methodsmentioning

confidence: 99%

Effects of mulberry heartwood extract on genes related to lipid metabolism

Pasheva

Nashar

Tasinov

et al. 2015

Scripta Scientifica Pharmaceutica

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Red yeast rice extracts suppress adipogenesis by down-regulating adipogenic transcription factors and gene expression in 3T3-L1 cells

Cited by 118 publications

References 29 publications

Red mold rice prevents the development of obesity, dyslipidemia and hyperinsulinemia induced by high-fat diet

Red mold rice prevents the development of obesity, dyslipidemia and hyperinsulinemia induced by high-fat diet

Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells

Effects of mulberry heartwood extract on genes related to lipid metabolism

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