Redefining the clinical remission period in children with type 1 diabetes

Chase, H. Peter; MacKenzie, Todd A.; Burdick, Jonathan; Fiallo‐Scharer, Rosanna; Walravens, P.; Klingensmith, Georgeanna J.; Rewers, Marian

doi:10.1111/j.1399-543x.2004.00034.x

Cited by 57 publications

(55 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We found that patients with autoantibody negative diabetes have a highly preserved beta cell function after 20 years in contrast to antibody positive patients. This is well in line with what has previously been described for T1D [1,2] but in contrast to the general view of progressive beta cell damage in T2D [3].…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

No signs of progressive beta cell damage during 20 years of prospective follow-up of autoantibody-negative diabetes

et al. 2011

View full text Add to dashboard Cite

Aims Both type 1 (T1D) and type 2 (T2D) diabetes are considered to be associated with different degrees of progressive beta cell damage. However, few long term studies have been made. Our aim was to study the clinical course of 20 years of diabetes disease, including diabetes progression, co-morbidity and mortality in a prospectively studied cohort of consecutively diagnosed diabetic patients.Methods Among all 233 patients diagnosed with diabetes during 1985-1987 in Malmö, Sweden, 50 of 118 surviving patients were followed-up after 20 years. The age at diagnose was 42.323.1 and 57.513.6 yrs for antibody positive and antibody negative patients, respectively. HbA1c and plasma lipids were analysed with regard to metabolic control.Results Islet antibody negative patients at diagnosis had highly preserved C-peptide levels after 20 years in contrast to antibody positive patients (antibody-negative: C-peptide 0yrs 0.780.47 and 20yrs 0.700.46 (nmol/l), p=0.51 and antibody-positive: C-peptide 0yrs 0.330.35 and 20yrs 0.100.18; p<0.001. Islet antibodies but not age, BMI or C-peptide at diagnosis were predictors of C-peptide levels at 20 years when analysed by logistic regression (p<0.05). HbA1c did not differ between the groups after 20 years. The 20-year mortality was higher among antibody-negative patients, dependent on the higher age at diagnosis in this group (number of deaths: antibody-positive: 18 of 56 vs. antibody-negative: 109 of 188, p<0.001). Of the deceased, 79 % had died from diseases or complications that may be associated to diabetes. ConclusionWe found no progressive beta cell damage in autoantibody negative diabetes at a 20 year follow-up of the clinical course of diabetes.

show abstract

Section: Discussionsupporting

confidence: 92%

“…Type 1 and type 2 diabetes are different in terms of aetiology and clinical course but have both been proposed to be associated with progressive beta cell damage [1][2][3]. However, this notion has been questioned.…”

Section: Introductionmentioning

confidence: 99%

No signs of progressive beta cell damage during 20 years of prospective follow-up of autoantibody-negative diabetes

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Patients with fulminant type 1 diabetes tended to have higher insulin requirements than those with non-fulminant type 1 diabetes during the first 6 months after diagnosis, and fair glycaemic control was maintained in both groups (data not shown). Interestingly, 30 of the 68 patients with autoimmune type 1 diabetes had a 'honeymoon period', arbitrarily defined as a period with insulin requirements of less than 0.5 U kg −1 day −1 [9], whereas none of the fulminant type 1 diabetes patients did. The characteristics of the individual patients with fulminant type 1 diabetes are shown in Table 2.…”

Section: Resultsmentioning

confidence: 99%

“…Insulin requirements as unit per kilogram per day and HbA 1c levels up to 1 year after initial diagnosis were reviewed to examine the presence of a 'honeymoon period', which was arbitrarily defined as a period with insulin requirements of <0.5 U kg −1 day −1 [9].…”

Section: Methodsmentioning

confidence: 99%

Fulminant type 1 diabetes in Korea: high prevalence among patients with adult-onset type 1 diabetes

Cho

Kim

et al. 2007

Diabetologia

View full text Add to dashboard Cite

show abstract

“…Forty percent of cases develop the onset of the disease before the age of 20, making it one of the most common severe chronic childhood illnesses [3][4][5]. T1D is the leading cause of end-stage renal disease, blindness, and amputation in many communities, and is a major cause of cardiovascular disease and premature death in the general population [6].…”

Section: Introductionmentioning

confidence: 99%

Genes Mediating Environment Interactions in Type 1 Diabetes

Biroš

Jordan²,

Baxter

2005

Rev Diabetic Stud

View full text Add to dashboard Cite

■ AbstractThe relative risk of type 1 (autoimmune) diabetes mellitus for a sibling of an affected patient is fifteen times that of the general population, indicating a strong genetic contribution to the disease. Yet, the incidence of diabetes in most Western communities has doubled every fifteen years since the Second World War -a rate of increase that can only possibly be explained by a major etiological effect of environment.Here, the authors provide a selective review of risk factors identified to date. Recent reports of linkage of type 1 diabetes to genes encoding pathogen pattern recognition molecules, such as toll-like receptors, are discussed, providing a testable hypothesis regarding a mechanism by which genetic and environmental influences on disease progress are integrated.

show abstract

Redefining the clinical remission period in children with type 1 diabetes

Cited by 57 publications

References 10 publications

No signs of progressive beta cell damage during 20 years of prospective follow-up of autoantibody-negative diabetes

No signs of progressive beta cell damage during 20 years of prospective follow-up of autoantibody-negative diabetes

Fulminant type 1 diabetes in Korea: high prevalence among patients with adult-onset type 1 diabetes

Genes Mediating Environment Interactions in Type 1 Diabetes

Contact Info

Product

Resources

About