Redefining the potential applications of dental stem cells: An asset for future

Abstract

Recent exciting discoveries isolated dental stem cells from the pulp of the primary and permanent teeth, from the periodontal ligament, and from associated healthy tissues. Dental pulp stem cells (DPSCs) represent a kind of adult cell colony which has the potent capacity of self-renewing and multilineage differentiation. Stem cell-based tooth engineering is deemed as a promising approach to the making of a biological tooth (bio-tooth) or engineering of functional tooth structures. Dental professionals have the opportunity to make their patients aware of these new sources of stem cells that can be stored for future use as new therapies are developed for a range of diseases and injuries. The aim of this article is to review and understand how dental stem cells are being used for regeneration of oral and conversely nonoral tissues. A brief review on banking is also done for storing of these valuable stem cells for future use.

Perception of Dental Scientists and Post-Graduate Students Regarding Future Prospects of Stem Cells in Dentistry

“…Izvori postnatalnih dentalnih matičnih stanica su trajni i mliječni zubi, parodontni ligament, zubna papila, prekobrojni zubi, ekstrahirani zubi u ortodontske svrhe te stanice dentalnog folikula, pulpe i zubnog folikula (2,4) Matične stanice iz zubne pulpe (DPSC, eng. Dental Pulp Stem Cells), SHED-a, zubne papile, stanica zubnog folikula i parodontnog ligamenta dostupne su i mogu se pohraniti, pa su jeftina investicija u slučaju liječenja bolesti.…”

“…Dental Pulp Stem Cells), SHED-a, zubne papile, stanica zubnog folikula i parodontnog ligamenta dostupne su i mogu se pohraniti, pa su jeftina investicija u slučaju liječenja bolesti. Stanice SHED-a mogu se dobiti iz prirodno ispalih mliječnih zuba i iskoristiti se kao izvor postnatalnog ljudskog tkiva (4,5,6).…”

“…Takve licencirane ustanove u Indiji su Reliance life Science -Delhi, Life cell -Chennai, Stemade Biotech Pvt. Ltd. -Indija i The Norwegian Tooth Bank (4).…”

“…Its application for treatment of severe combined immune deficiency was established in 1968, (3). National Institute of Health (NIH) in 2000 mentioned the discovery of adult stem cells in impacted third molars and more resilient stem cells in deciduous teeth with SHED (Stem cells from Human Exfoliated Deciduous teeth) discovered by Dr. Shi in 2003 (4).…”

“…Sources of postnatal dental stem cells include permanent teeth, deciduous teeth, periodontal ligament, stem cells from apical papilla and stem cells from supernumerary tooth, stem cells from teeth extracted for orthodontic purposes, dental follicle progenitor cells, stem cells from human natal dental pulp, and stem cells from dental follicle (2,4).…”