Redox-Active AIEgen-Derived Plasmonic and Fluorescent Core@Shell Nanoparticles for Multimodality Bioimaging

He, Xuewen; Zhao, Zheng; Xiong, Ling‐Hong; Gao, Peng Fei; Peng, Chen; Li, Rong Sheng; Xiong, Yu; Li, Zhi; Sung, Herman H. Y.; Williams, Ian D.; Kwok, Ryan T. K.; Lam, Jacky W. Y.; Huang, Cheng; Ma, Nan; Tang, Ben Zhong

doi:10.1021/jacs.8b02350

Cited by 117 publications

(138 citation statements)

References 50 publications

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“…Moreover, TPE‐2M2F N‐oxide displayed a faster reduction rate by Fe 2+ . In terms of the reported literatures, it was deduced that the electron‐withdrawing nature of the fluorine atoms caused an increase of the reduction potential to allow TPE‐2M2F N‐oxide to obtain electrons from Fe 2+ more easily . However, TPE‐2E N‐oxide showed only a negligible response to Fe 2+ under the same incubation condition (Figure S14B, Supporting Information).…”

Section: Resultsmentioning

confidence: 59%

A New Strategy toward “Simple” Water‐Soluble AIE Probes for Hypoxia Detection

Zou

Zhao

et al. 2019

Adv Funct Materials

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Hypoxia-responsive fluorescent probes have emerged as a novel scaffold for tumor diagnosis. However, dilemma often exists between simple synthesis and high water solubility in traditional probes. Owing to the intrinsic property of N-oxides, herein, a new strategy is proposed to design and synthesize probes for in vitro hypoxia imaging. Equipped with tetraphenylethene (TPE), the N-oxides exhibit aggregation-induced emission characteristics and emit no light in aqueous solutions. Interestingly, the N-oxides can be reduced by ferrous ions in different rates. The aggregation of the resulting hydrophobic TPE residues restricts the intramolecular motions of the molecules, which "turns-on" their fluorescence. The NO covalent bond of one molecule can be specifically cleaved by cellular reductase overexpressed under hypoxic conditions, and thus turn-on hypoxia imaging in vitro is achieved. The new strategy to design hypoxia imaging probes is extremely valuable and has great potential for application in tumor diagnosis.

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Section: Resultsmentioning

confidence: 59%

A New Strategy toward “Simple” Water‐Soluble AIE Probes for Hypoxia Detection

Zou

Zhao

et al. 2019

Adv Funct Materials

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“…Driven by this, an increasing number of researchers have devoted themselves to developing multifunctional nanomaterials for tumor diagnosis and treatment [4][5][6] . Among them, core-shell nanohybrids have received tremendous attention due to the integration of multiple functionalities into the nanohybrid that go beyond the intrinsic limitations of individual components in the imaging and treatment of tumors [7][8][9][10] . Considering that the shell thickness will greatly affect the performance of the core-shell nanohybrid, it is of critical importance to control the shell structure while integrating functionality into nanohybrids [11][12][13][14][15] .…”

Section: Introductionmentioning

confidence: 99%

Controlled synthesis of a core-shell nanohybrid for effective multimodal image-guided combined photothermal/photodynamic therapy of tumors

Cheng

Sun

et al. 2019

NPG Asia Mater

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In this paper, a simple strategy is proposed to prepare a core-shell nanohybrid (PB@PCN) by the controllable coating of zirconium-porphyrin (PCN) shells on Prussian blue (PB) nanoparticles. By adjusting the thickness of the PCN shell, the PB@PCN nanohybrid with the best comprehensive performance was obtained for tumor treatment and imaging. The integrated nanosystem as a tandem catalyst is able to convert H 2 O 2 to O 2 through the PB core, and then the O 2 is directly injected into the PCN framework, leading to a high quantum yield of singlet oxygen to kill tumor cells and attack heat shock proteins (HSPs). The nanohybrid was further camouflaged by a tumor cell membrane (PB@PCN@MEM) with good immune evasion and active targeting ability. Upon accumulation at the tumor site, PN@PCN@MEM showed an enhanced photodynamic therapeutic effect against hypoxic tumor cells. Furthermore, coupled with the photothermal therapy of PB, photothermal/photodynamic synergistic therapy of tumors can be realized. In addition, due to its excellent imaging performance, this core-shell nanohybrid can be employed for the multimodal image-guided therapy of tumors.

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“…Currently, several multimodal imaging techniques based on AIEgens have been developed. For example, dual MRI and fluorescence imaging, dual CT and fluorescence imaging, and dual PAI and fluorescence imaging, as well as triple‐modal imaging of fluorescence, dark‐field microscopy (DFM) and CT, and triple‐modal imaging of fluorescence, PA, and Raman …”

Section: In Vivo Vascular and Tumor‐targeted Imagingmentioning

confidence: 99%

Promising Applications of AIEgens in Animal Models

Situ

Zhao

et al. 2019

Small Methods

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organisms cannot be achieved from these static findings. Therefore, gaining in-depth insights into biological and physiological functions at the in vivo level is of great significance, and various imaging techniques have been explored for this purpose. [1] In addition to the clinically available magnetic resonance imaging (MRI), ultrasonic imaging, computed tomography (CT), positron emission tomography (PET), and single-photon emission computed tomography, fluorescence imaging (another distinct type of optical imaging [1c] from bioluminescence imaging [2] ) has attracted increasing attention, owing to its advantages of high temporal-spatial resolution and sensitivity, noninvasive, and real-time applications, and the ability to provide dynamic information for basic research and (pre-)clinical settings at cellular and subcellular levels. [3] Fluorescent probes or contrast agents are essential for fluorescence imaging. Compared with fluorescent proteins, [4] inorganic nanoparticles (NPs), [5] such as quantum dots, [6] upconversion NPs, [7] and metallic NPs, [8] and organic dyes [9] (e.g., U.S. Food and Drug Administration (FDA)-approved 5-ALA, indocyanine green (ICG), and methylene blue), organic NPs [10] have obvious advantages, such as easy preparation and good biocompatibility. However, many organic NPs show weak fluorescence because they are made with conventional organic dyes, which suffer from the aggregation-caused quenching (ACQ) effect, i.e., their fluorescence is partially or completely quenched in the aggregated state.The advent of the aggregation-induced emission (AIE) concept offers a new strategy to deal with ACQ. [11] AIE refers to the interesting photophysical phenomenon that luminogens are weakly fluorescent or nonfluorescent in solution but show greatly enhanced emission in the aggregated state, primarily because of restricted intramolecular motion. [12] The past 19 years have witnessed spectacular advances of AIEgens, [13] due to their advantages of structural variety, easy functionalization, strong luminescence, large Stokes shift, high photobleaching-resistance, and so on. In particular, various AIE bioprobes have been designed: [14] (i) water-soluble AIEgens, which are comprised of a hydrophobic AIE core and hydrophilic units (e.g., ionic groups, peptides, carbohydrates, DNA, aptamers, antibodies, and poly(ethylene glycol) (PEG)); (ii) bare AIEgen dots (nanoaggregates); iii) AIEgen/biopolymer dots, which can be obtained by loading AIEgens onto biopolymer matrixes covalently (e.g., chitosan, dextran, and starch) or noncovalently (e.g., bovine serum albumin, human serum albumin (HSA), and fetal bovine serum (FBS)); (iv)In vivo investigations using small animal models are of great significance for the comprehensive understanding of biological and physiological functions-seeing is believing. Fluorescence imaging can provide real-time and dynamic information of living systems. During the past few years, aggregation-induced emission luminogens (AIEgens) are widely and rapidly developed for biolog...

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Redox-Active AIEgen-Derived Plasmonic and Fluorescent Core@Shell Nanoparticles for Multimodality Bioimaging

Cited by 117 publications

References 50 publications

A New Strategy toward “Simple” Water‐Soluble AIE Probes for Hypoxia Detection

A New Strategy toward “Simple” Water‐Soluble AIE Probes for Hypoxia Detection

Controlled synthesis of a core-shell nanohybrid for effective multimodal image-guided combined photothermal/photodynamic therapy of tumors

Promising Applications of AIEgens in Animal Models

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