Redox-active antifungal cobalt(II) and copper(II) complexes with sterically hindered o-aminophenol derivatives

Loginova, N. V.; Ковальчук, Т. В.; Osipovich, N. P.; Полозов, Г. И.; Сорокин, В. Л.; Chernyavskaya, A. A.; Шадыро, О. И.

doi:10.1016/j.poly.2007.11.028

Cited by 25 publications

(9 citation statements)

References 46 publications

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“…The square planar Co(II) complexes are normally expected to exhibit transitions in these regions 12 -15 . The magnetic moment value 2.12 BM also corroborates the expected low-spin square planar geometry for Co(II) ions 15 .…”

Section: Resultssupporting

confidence: 77%

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2018

IJPSR

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Synthesis and characterization of Co(II), Ni(II), Cu(II) and Pd(II) complexes of ligand N '-[(2Z,3E)-3-(hydroxyimino) butan-2-ylidene] benzohydrazide are reported. The ligand is monobasic and bidentate in nature. The molar conductivities reveal that all the metal complexes are nonelectrolyte. The metal complexes have been characterized on the basis of spectral and magnetic studies. Co(II) ion forms brown complex Co(BBH) 2 which has low spin square planar geometry. The diamagnetic nature and the spectral features of the brown Ni(BBH) 2 complex suggests the square planar environment for the Ni(II) ion. Ni(BBH) 2 adds on two molecules of pyridine to form a high spin six coordinate adduct. The room temperature magnetic susceptibility measurements of the pyridine adduct of Ni(BBH) 2 indicates octahedral nature of the complex which is further supported by the absorption spectrum. The magnetic data in case of Cu(BBH) 2 indicates presence of one unpaired electron in Cu(II) ion. The EPR spectrum of Cu(BBH) 2 suggests the square planar geometry which is further supported by electronic absorption spectrum of the complex. Studies reveal square planar geometry for Pd(BBH) 2 complex.

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Section: Resultssupporting

confidence: 77%

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2018

IJPSR

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“…Several square-planar cobalt(II) complexes have been reported, but those contain higher-order hapticity ligands such as pincers (tridentate, neutral, or monoanionic), porphyrins (tetradentate and dianionic), or salens (tetradentate and dianionic). , There are rare examples of square-planar Co(II) complexes featuring bidentate ligands but only when those ligands are negatively charged (e.g. aminophenol) . To the best of our knowledge, this is the first crystallographically characterized square-planar Co(II) complex containing only neutral, bidentate ligands.…”

Section: Resultsmentioning

confidence: 87%

Tuning Cobalt(II) Phosphine Complexes to be Axially Ambivalent

et al. 2022

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We report the isolation and characterization of a series of three cobalt(II) bis(phosphine) complexes with varying numbers of coordinated solvent ligands in the axial position. X-ray quality crystals of [Co(dppv) 2 ][BF 4 ] 2 (1) , [Co(dppv) 2 (NCCH 3 )][BPh 4 ] 2 (2) , and [Co(dppv) 2 (NCCH 3 ) 2 ][BF 4 ] 2 (3) (dppv = cis -1,2-bis(diphenylphosphino)ethylene) were grown under slightly different conditions, and their structures were compared. This analysis revealed multiple crystallization motifs for divalent cobalt(II) complexes with the same set of phosphine ligands. Notably, the 4-coordinate complex 1 is a rare example of a square-planar cobalt(II) complex, the first crystallographically characterized square-planar Co(II) complex containing only neutral, bidentate ligands. Characterization of the different axial geometries via EPR and UV–visible spectroscopies showed that there is a very shallow energy landscape for axial ligation. Ligand field angular overlap model calculations support this conclusion, and we provide a strategy for tuning other ligands to be axially labile on a phosphine scaffold. This methodology is proposed to be used for designing cobalt phosphine catalysts for a variety of oxidation and reduction reactions.

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“…Their synthesis, their separation as crystalline powders, the composition, and physicochemical characteristics of the complexes were also studied in Ref. [7].…”

Section: Introductionmentioning

confidence: 99%

Metal Complexes of Pharmaceutical Substances

Jurca¹,

Marian²,

Vicaş³

et al. 2017

Spectroscopic Analyses - Developments and Applications

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Significant progresses have been made in the inorganic and organic chemistry up to the present concerning the synthesis, characterization, and application of the metal complexes of pharmaceutical substances. From the wide range of fields in which these coordination compounds find their application, many efforts were focused on the study of their importance in the biological processes. The coordination complexes of many pharmaceutical substances having different pharmacological effects e.g., pyrazinamide (PZA), nicotinamide (NAM), nicotinic acid (NIC), theophylline (TEO), captopril (CPL), tolbutamide (TBA), clonidine (CLN), guanfacine (GUAF), etc. with transition metals were synthesized and used in order to improve their pharmacological and pharmacotechnical properties and also for the drug analysis and control. Several techniques such as Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, surface-enhanced Raman spectroscopy (SERS), X-ray spectroscopy, mass spectrometry, ultraviolet-visible (UV-Vis) spectrophotometry, electron paramagnetic resonance (EPR) spectroscopy, X-ray diffraction, elemental analysis, electrochemical methods, thermal methods, and scanning electron microscopy were used for the physicochemical characterization of the complex composition. A significant interest in the development of metal complex-based drugs with unique research and therapeutic and diagnostic opportunities is currently observed in the medicinal inorganic chemistry area.

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Redox-active antifungal cobalt(II) and copper(II) complexes with sterically hindered o-aminophenol derivatives

Cited by 25 publications

References 46 publications

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Tuning Cobalt(II) Phosphine Complexes to be Axially Ambivalent

Metal Complexes of Pharmaceutical Substances

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