Redox-responsive microbeads containing thiolated pectin-doxorubicin conjugate inhibit tumor growth and metastasis: An in vitro and in vivo study

Cheewatanakornkool, Kamonrak; Niratisai, Sathit; Dass, Crispin R.; Sriamornsak, Pornsak

doi:10.1016/j.ijpharm.2018.04.052

Cited by 23 publications

(9 citation statements)

References 42 publications

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“…On the other hand, there is also an increased interest in how the redox state may be used as a stimulus in the development of active implants, tuning their response to the local microenvironment. Redox-responsive biomaterials are being studied for drug delivery, with promising results ( Yang et al, 2014 ; Cheewatanakornkool et al, 2018 ; Gong et al, 2018 ; Yu et al, 2020 ). A bio-inspired approach to infection control through active implant generation of ROS has been tested.…”

Section: Discussionmentioning

confidence: 99%

In Sickness and in Health: The Oxygen Reactive Species and the Bone

Reis

Ramos

2021

Front. Bioeng. Biotechnol.

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Oxidative stress plays a central role in physiological and pathological bone conditions. Its role in signalment and control of bone cell population differentiation, activity, and fate is increasingly recognized. The possibilities of its use and manipulation with therapeutic goals are virtually unending. However, how redox balance interplays with the response to mechanical stimuli is yet to be fully understood. The present work summarizes current knowledge on these aspects, in an integrative and broad introductory perspective.

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Section: Discussionmentioning

confidence: 99%

In Sickness and in Health: The Oxygen Reactive Species and the Bone

Reis

Ramos

2021

Front. Bioeng. Biotechnol.

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“…Scanning electron microscopy (SEM) is a valuable tool for evaluating pectin hydrogels, providing high-resolution images of their microstructure. SEM enables researchers to observe the surface morphology and structural features of pectin-based hydrogels, offering insights into their texture, pore distribution, and overall architecture ( Cheewatanakornkool et al, 2018 ). This method aids in understanding how changes in the formulation or crosslinking methods affect the physical characteristics of the hydrogel ( Alsakhawy et al, 2022 ).…”

Section: Pectin-based Hydrogels For Drug Deliverymentioning

confidence: 99%

“…These hydrogels enable targeted drug delivery, enhancing therapeutic efficacy and minimizing systemic side effects. Their potential in localized cancer treatment holds promise for improved patient outcomes ( Cheewatanakornkool et al, 2017 , Cheewatanakornkool et al, 2018 ).…”

Section: Pectin Hydrogel Applications In Drug Deliverymentioning

confidence: 99%

Pectin hydrogels for controlled drug release: Recent developments and future prospects

Kapoor,

Garg,

Gaur

et al. 2024

Saudi Pharmaceutical Journal

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“…[138] Several formulations developed from naturally derived biomaterials exploit this distinguished characteristic of tumor cells to confer selective targeting to anticancer cargoes. Numerous redox-sensitive NPVs like thiolated polymers (e.g., pectin, chitosan, sodium alginate, dextran, hyaluronic acid, polymerized starch), [83] cysteamine-conjugated starch/pullulan, [139] xanthan gum, [140] carboxymethyl chitosan, [141] keratin, [142] xylan, [138] etc. have been exploited for oral delivery of NAAs.…”

Section: Redox-responsive Nanocarriersmentioning

confidence: 99%

“…The drug‐loaded NPVs displayed promoted anticancer activity, while being stable under the GI conditions. [ 83 ]…”

Section: Stimuli Responsive Npvs For Oral Delivery Of Naasmentioning

confidence: 99%

Biopolymer Nanovehicles for Oral Delivery of Natural Anticancer Agents

Falsafi

Wang

Ashaolu

et al. 2022

Adv Funct Materials

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Cancer is the second leading cause of death throughout the world. Nature‐inspired anticancer agents (NAAs) that are a gift of nature to humanity have been extensively utilized in the alleviation/prevention of the disease due to their numerous pharmacological activities. While the oral route is an ideal and common way of drug administration, the application of NAAs through the oral pathway has been extremely limited owing to their inherent features, e.g., poor solubility, gastrointestinal (GI) instability, and low bioavailability. With the development of nano‐driven encapsulation strategies, polymeric vehicles, especially those with natural origins, have demonstrated a potent platform, which can professionally shield versatile NAAs against GI barricades and safely deliver them to the site of action. In this review, the predicament of orally delivering NAAs and the encapsulation strategy solutions based on biopolymer matrices are summarized. Proof‐of‐concept in vitro/in vivo results are also discussed for oral delivery of these agents by various biopolymer vehicles, which can be found so far from the literature. Last but not the least, the challenges and new opportunities in the field are highlighted.

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Redox-responsive microbeads containing thiolated pectin-doxorubicin conjugate inhibit tumor growth and metastasis: An in vitro and in vivo study

Cited by 23 publications

References 42 publications

In Sickness and in Health: The Oxygen Reactive Species and the Bone

In Sickness and in Health: The Oxygen Reactive Species and the Bone

Pectin hydrogels for controlled drug release: Recent developments and future prospects

Biopolymer Nanovehicles for Oral Delivery of Natural Anticancer Agents

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